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Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Rapid Commun Mass Spectrom. 2005; 19(21):3119-30.RC

Abstract

Electrospray ionization quadrupole time-of-flight (ESI-QqToF) mass spectra of naltrindole hydrochloride 1, naltriben mesylate 2, and naltrexone hydrochloride 3, a common series of morphine opiate receptor antagonists, were recorded using different declustering potentials. Low-energy collision-induced dissociation (CID) MS/MS experiments established the fragmentation routes of these compounds. In addition, re-confirmation of the various established fragmentation routes was effected by conducting a series of ESI-CID-QqTof-MS/MS experiments using non-conventional quasi MS(n) (up to MS8) product ion scans, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. Precursor ion scan analyses were also performed with a conventional quadrupole-hexapole-quadrupole tandem mass spectrometer and allowed the confirmation of the genesis of some diagnostic ions.

Authors+Show Affiliations

Laboratoire de le Barrière Hémato-Encéphalique, E.A. 2465, Département de Chimie, Université d'Artois, Béthune, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16200660

Citation

Joly, Nicolas, et al. "Structural Determination of the Novel Fragmentation Routes of Morphine Opiate Receptor Antagonists Using Electrospray Ionization Quadrupole Time-of-flight Tandem Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 19, no. 21, 2005, pp. 3119-30.
Joly N, El Aneed A, Martin P, et al. Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(21):3119-30.
Joly, N., El Aneed, A., Martin, P., Cecchelli, R., & Banoub, J. (2005). Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 19(21), 3119-30.
Joly N, et al. Structural Determination of the Novel Fragmentation Routes of Morphine Opiate Receptor Antagonists Using Electrospray Ionization Quadrupole Time-of-flight Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2005;19(21):3119-30. PubMed PMID: 16200660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry. AU - Joly,Nicolas, AU - El Aneed,Anas, AU - Martin,Patrick, AU - Cecchelli,Roméo, AU - Banoub,Joseph, PY - 2005/10/4/pubmed PY - 2005/12/15/medline PY - 2005/10/4/entrez SP - 3119 EP - 30 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 19 IS - 21 N2 - Electrospray ionization quadrupole time-of-flight (ESI-QqToF) mass spectra of naltrindole hydrochloride 1, naltriben mesylate 2, and naltrexone hydrochloride 3, a common series of morphine opiate receptor antagonists, were recorded using different declustering potentials. Low-energy collision-induced dissociation (CID) MS/MS experiments established the fragmentation routes of these compounds. In addition, re-confirmation of the various established fragmentation routes was effected by conducting a series of ESI-CID-QqTof-MS/MS experiments using non-conventional quasi MS(n) (up to MS8) product ion scans, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. Precursor ion scan analyses were also performed with a conventional quadrupole-hexapole-quadrupole tandem mass spectrometer and allowed the confirmation of the genesis of some diagnostic ions. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/16200660/Structural_determination_of_the_novel_fragmentation_routes_of_morphine_opiate_receptor_antagonists_using_electrospray_ionization_quadrupole_time_of_flight_tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.2179 DB - PRIME DP - Unbound Medicine ER -