[Immunological classification of 112 adult acute leukemia patients].Zhonghua Xue Ye Xue Za Zhi. 2001 Dec; 22(12):633-5.ZX
To explore the criteria and significance of immunological classification in adult acute leukemias.
One or two color monoclonal antibodies directly labeled with immunofluorescence were used to analyse the surface and cytoplasma antigens by flow cytometry, and an antibody integral system was developed for the immunologic classification.
One hundred and twelve adult acute leukemia cases were detected. (1) The undifferentiated phenotype account for 0.9%, simple 51.8%, variant 38.4% and mixed lineage 8.9%. (2) The abnormal expressions of antigen in variant and mixed lineage phenotype were CD7, CD33, CD10, CD13, CD19 and CD20, by order of decreased level.
The strict, numerical diagnostic criteria was very convenient and useful for immunophenotyping of adult acute leukemia.