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[The effect of estrogen receptor gene Px haplotype on bone mineral density in Chinese postmenopausal women].
Zhonghua Yi Xue Za Zhi. 2001 Nov 10; 81(21):1295-7.ZY

Abstract

OBJECTIVE

To investigate the relationship among the PvuII and XbaI polymorphism of estrogen receptor (ER) gene and bone mineral density (BMD, z-score) and bone biochemical markers in Chinese postmenopausal women.

METHODS

The BMD of lumbar vertebrae (L2-4) and femoral neck (FN) of 186 postmenopausal women (aged 65.0 +/- 0.6 yr) were measured by DEXA. The polymorphism of ER gene (PvuII and XbaI) was detected by PCR-RFLP method. Serum AKP, BGP and urinary Pyd were measured by ELISA. Results The polymorphism of ER receptor can be divided into two sets: PP (14.5%), Pp (50.0%), and pp (35.5%); and 3 PvulI RFLPs and XX (7.0%), Xx (27.4%), and xx (65.6%) 3 XbaI RFLPs. The bone markers were not significantly different among the 3 groups in each of the two sets of polymorphism. The FN BMD of women of pp genotype was higher than that of Pp genotype (P = 0.02). The BMD of 12-4 was higher in women of XX genotype than those in women of Xx and xx genotypes (P = 0.0003 and 0.0002 respectively). Women without Px haplotype (PPXX, PpXX, ppxx, n=79) had higher L2-4 BMD (P = 0.02) and FN BMD (P = 0.03) and lower serum AKP (P = 0.04) than those with Px genotype (PPxx and PPXx, Ppxx, PpXx, n=107).

CONCLUSION

pp and XX genotype of ER gene may play a certain role in maintaining FN and L2-4 BMD. The genotypes without Px haplotype might exert some favorable effect on BMD, while those with Px haplotype may be harmful to bone

Authors+Show Affiliations

Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

16200719

Citation

Liu, J, et al. "[The Effect of Estrogen Receptor Gene Px Haplotype On Bone Mineral Density in Chinese Postmenopausal Women]." Zhonghua Yi Xue Za Zhi, vol. 81, no. 21, 2001, pp. 1295-7.
Liu J, Zhu H, Zhu X. [The effect of estrogen receptor gene Px haplotype on bone mineral density in Chinese postmenopausal women]. Zhonghua Yi Xue Za Zhi. 2001;81(21):1295-7.
Liu, J., Zhu, H., & Zhu, X. (2001). [The effect of estrogen receptor gene Px haplotype on bone mineral density in Chinese postmenopausal women]. Zhonghua Yi Xue Za Zhi, 81(21), 1295-7.
Liu J, Zhu H, Zhu X. [The Effect of Estrogen Receptor Gene Px Haplotype On Bone Mineral Density in Chinese Postmenopausal Women]. Zhonghua Yi Xue Za Zhi. 2001 Nov 10;81(21):1295-7. PubMed PMID: 16200719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of estrogen receptor gene Px haplotype on bone mineral density in Chinese postmenopausal women]. AU - Liu,J, AU - Zhu,H, AU - Zhu,X, PY - 2005/10/5/pubmed PY - 2009/11/5/medline PY - 2005/10/5/entrez SP - 1295 EP - 7 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 81 IS - 21 N2 - OBJECTIVE: To investigate the relationship among the PvuII and XbaI polymorphism of estrogen receptor (ER) gene and bone mineral density (BMD, z-score) and bone biochemical markers in Chinese postmenopausal women. METHODS: The BMD of lumbar vertebrae (L2-4) and femoral neck (FN) of 186 postmenopausal women (aged 65.0 +/- 0.6 yr) were measured by DEXA. The polymorphism of ER gene (PvuII and XbaI) was detected by PCR-RFLP method. Serum AKP, BGP and urinary Pyd were measured by ELISA. Results The polymorphism of ER receptor can be divided into two sets: PP (14.5%), Pp (50.0%), and pp (35.5%); and 3 PvulI RFLPs and XX (7.0%), Xx (27.4%), and xx (65.6%) 3 XbaI RFLPs. The bone markers were not significantly different among the 3 groups in each of the two sets of polymorphism. The FN BMD of women of pp genotype was higher than that of Pp genotype (P = 0.02). The BMD of 12-4 was higher in women of XX genotype than those in women of Xx and xx genotypes (P = 0.0003 and 0.0002 respectively). Women without Px haplotype (PPXX, PpXX, ppxx, n=79) had higher L2-4 BMD (P = 0.02) and FN BMD (P = 0.03) and lower serum AKP (P = 0.04) than those with Px genotype (PPxx and PPXx, Ppxx, PpXx, n=107). CONCLUSION: pp and XX genotype of ER gene may play a certain role in maintaining FN and L2-4 BMD. The genotypes without Px haplotype might exert some favorable effect on BMD, while those with Px haplotype may be harmful to bone SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/16200719/[The_effect_of_estrogen_receptor_gene_Px_haplotype_on_bone_mineral_density_in_Chinese_postmenopausal_women]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2001&vol=81&issue=21&fpage=1295 DB - PRIME DP - Unbound Medicine ER -