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[Study on fingerprint of unfinished product of Nauclea injection].
Zhongguo Zhong Yao Za Zhi. 2005 Aug; 30(15):1156-8.ZZ

Abstract

OBJECTIVE

To establish HPLC fingerprints of unfinished product of Nauclea injection.

METHOD

A high performance liquid chromatography assay was developed with an Agilent-Extend C18 column, a gradient elution:water-5% acetonitrile (10 min), 5% acetonitrile-10% acetonitrile (10-60 min), 50% acetonitrile-water (60-70 min), a 0.7 mL x min(-1) flow rate, at detection wavelength, 245 nm within a 70 min total elution time.

RESULT

The RSD of relative retention time and peak area of coexist peaks meet to method requirement during the investigation of precision, stability and repeatibity trials. All of the 10 batches of samples share a high similarity.

CONCLUSION

This method can be used to control the quality of unfinished product of Nauclea injection.

Authors+Show Affiliations

Li T
Beijing Hospital, Beijing 100730, China. tao-lee-2000@sina.com
Wang WJ
No affiliation info available
Hu X
No affiliation info available

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalInjectionsPlants, MedicinalQuality ControlReproducibility of ResultsRubiaceae

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16201688

Citation

Li, Tao, et al. "[Study On Fingerprint of Unfinished Product of Nauclea Injection]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 30, no. 15, 2005, pp. 1156-8.
Li T, Wang WJ, Hu X. [Study on fingerprint of unfinished product of Nauclea injection]. Zhongguo Zhong Yao Za Zhi. 2005;30(15):1156-8.
Li, T., Wang, W. J., & Hu, X. (2005). [Study on fingerprint of unfinished product of Nauclea injection]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 30(15), 1156-8.
Li T, Wang WJ, Hu X. [Study On Fingerprint of Unfinished Product of Nauclea Injection]. Zhongguo Zhong Yao Za Zhi. 2005;30(15):1156-8. PubMed PMID: 16201688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on fingerprint of unfinished product of Nauclea injection]. AU - Li,Tao, AU - Wang,Wei-Jian, AU - Hu,Xin, PY - 2005/10/6/pubmed PY - 2007/1/24/medline PY - 2005/10/6/entrez SP - 1156 EP - 8 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 30 IS - 15 N2 - OBJECTIVE: To establish HPLC fingerprints of unfinished product of Nauclea injection. METHOD: A high performance liquid chromatography assay was developed with an Agilent-Extend C18 column, a gradient elution:water-5% acetonitrile (10 min), 5% acetonitrile-10% acetonitrile (10-60 min), 50% acetonitrile-water (60-70 min), a 0.7 mL x min(-1) flow rate, at detection wavelength, 245 nm within a 70 min total elution time. RESULT: The RSD of relative retention time and peak area of coexist peaks meet to method requirement during the investigation of precision, stability and repeatibity trials. All of the 10 batches of samples share a high similarity. CONCLUSION: This method can be used to control the quality of unfinished product of Nauclea injection. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/16201688/[Study_on_fingerprint_of_unfinished_product_of_Nauclea_injection]_ DB - PRIME DP - Unbound Medicine ER -