Tags

Type your tag names separated by a space and hit enter

Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero.
East Mediterr Health J. 2004 Jan-Mar; 10(1-2):96-105.EM

Abstract

Neonate meconium cotinine level was evaluated as a marker of prenatal exposure to nicotine from tobacco smoking by mothers. Mothers admitted to a maternity hospital in Alexandria, Egypt, were divided into 3 groups: 10 active smokers, 10 passive smokers and 10 with no tobacco exposure during pregnancy. Urine and saliva samples were collected from mothers and first-day meconium samples from their neonates. Mean maternal urinary cotinine levels, measured using radioimmunoassay, differed significantly between the 3 groups, as did mean salivary cotinine and mean cotinine levels in meconium. There was a significant positive correlation between cotinine levels in meconium and both maternal urinary and salivary cotinine levels. Meconium is an ideal biological marker for testing direct fetal exposure to tobacco smoke in the neonatal period.

Authors+Show Affiliations

Sherif NA
Department of Forensic Medicine and Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
Kamel SM
No affiliation info available
Al-Ashkar OS
No affiliation info available
Sharaki OA
No affiliation info available
Seif EA
No affiliation info available
Hegazy EA
No affiliation info available

MeSH

AdolescentAdultAnalysis of VarianceBiomarkersBirth WeightCase-Control StudiesCotinineEgyptFemaleFetal HypoxiaHospitals, UniversityHumansInfant, NewbornMaternal-Fetal ExchangeMeconiumPregnancyPregnancy ComplicationsRadioimmunoassaySalivaSmokingSurveys and QuestionnairesTobacco Smoke Pollution

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

16201714

Citation

Sherif, N A., et al. "Detection of Cotinine in Neonate Meconium as a Marker for Nicotine Exposure in Utero." Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, vol. 10, no. 1-2, 2004, pp. 96-105.
Sherif NA, Kamel SM, Al-Ashkar OS, et al. Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero. East Mediterr Health J. 2004;10(1-2):96-105.
Sherif, N. A., Kamel, S. M., Al-Ashkar, O. S., Sharaki, O. A., Seif, E. A., & Hegazy, E. A. (2004). Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero. Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, 10(1-2), 96-105.
Sherif NA, et al. Detection of Cotinine in Neonate Meconium as a Marker for Nicotine Exposure in Utero. East Mediterr Health J. 2004 Jan-Mar;10(1-2):96-105. PubMed PMID: 16201714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero. AU - Sherif,N A, AU - Kamel,S M, AU - Al-Ashkar,O S, AU - Sharaki,O A, AU - Seif,E A, AU - Hegazy,E A, PY - 2005/10/6/pubmed PY - 2005/11/9/medline PY - 2005/10/6/entrez SP - 96 EP - 105 JF - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JO - East Mediterr Health J VL - 10 IS - 1-2 N2 - Neonate meconium cotinine level was evaluated as a marker of prenatal exposure to nicotine from tobacco smoking by mothers. Mothers admitted to a maternity hospital in Alexandria, Egypt, were divided into 3 groups: 10 active smokers, 10 passive smokers and 10 with no tobacco exposure during pregnancy. Urine and saliva samples were collected from mothers and first-day meconium samples from their neonates. Mean maternal urinary cotinine levels, measured using radioimmunoassay, differed significantly between the 3 groups, as did mean salivary cotinine and mean cotinine levels in meconium. There was a significant positive correlation between cotinine levels in meconium and both maternal urinary and salivary cotinine levels. Meconium is an ideal biological marker for testing direct fetal exposure to tobacco smoke in the neonatal period. SN - 1020-3397 UR - https://www.unboundmedicine.com/medline/citation/16201714/Detection_of_cotinine_in_neonate_meconium_as_a_marker_for_nicotine_exposure_in_utero_ DB - PRIME DP - Unbound Medicine ER -