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Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio.
Mutat Res. 2005 Nov 10; 587(1-2):103-13.MR

Abstract

The use of chlorinated disinfectants during drinking-water production has been shown to generate halogenated compounds as a result of interactions of humic acids with chlorine. Such chlorinated by-products have been shown to induce genotoxic effects and consumption of chlorinated drinking-water has been correlated with increased risk for cancer induction in human populations. The aim of this work was to test the potential genotoxic effects on circulating erythrocytes of the fish Cyprinus carpio exposed in vivo to well-waters disinfected with sodium hypochlorite (NaClO), chlorine dioxide (ClO2) or peracetic acid (CH3COO2H, PAA), in the absence or presence of standard humic acids (HA). The effects were measured by use of the micronucleus (MN) and the single-cell gel electrophoresis (Comet) assays at different sampling times after a 3-day exposure period. The exposure to chlorine disinfectants without the addition of HA produced a clear toxic effect. Significant cytogenetic damage (i.e. MN induction) was detected in fish populations exposed to both NaClO and ClO2 with humic acids. In the Comet assay, a significant decrease of DNA migration was observed in erythrocytes of specimens after exposure to NaClO-disinfected water without HA. No effects were observed in any other experimental condition.

Authors+Show Affiliations

Dipartimento di Biologia, Università degli Studi di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy. gustavino@bio.uniroma2.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16202643

Citation

Gustavino, Bianca, et al. "Modulating Effects of Humic Acids On Genotoxicity Induced By Water Disinfectants in Cyprinus Carpio." Mutation Research, vol. 587, no. 1-2, 2005, pp. 103-13.
Gustavino B, Buschini A, Monfrinotti M, et al. Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio. Mutat Res. 2005;587(1-2):103-13.
Gustavino, B., Buschini, A., Monfrinotti, M., Rizzoni, M., Tancioni, L., Poli, P., & Rossi, C. (2005). Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio. Mutation Research, 587(1-2), 103-13.
Gustavino B, et al. Modulating Effects of Humic Acids On Genotoxicity Induced By Water Disinfectants in Cyprinus Carpio. Mutat Res. 2005 Nov 10;587(1-2):103-13. PubMed PMID: 16202643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio. AU - Gustavino,Bianca, AU - Buschini,Annamaria, AU - Monfrinotti,Monica, AU - Rizzoni,Marco, AU - Tancioni,Lorenzo, AU - Poli,Paola, AU - Rossi,Carlo, Y1 - 2005/10/03/ PY - 2005/03/30/received PY - 2005/08/03/revised PY - 2005/08/08/accepted PY - 2005/10/6/pubmed PY - 2005/12/21/medline PY - 2005/10/6/entrez SP - 103 EP - 13 JF - Mutation research JO - Mutat Res VL - 587 IS - 1-2 N2 - The use of chlorinated disinfectants during drinking-water production has been shown to generate halogenated compounds as a result of interactions of humic acids with chlorine. Such chlorinated by-products have been shown to induce genotoxic effects and consumption of chlorinated drinking-water has been correlated with increased risk for cancer induction in human populations. The aim of this work was to test the potential genotoxic effects on circulating erythrocytes of the fish Cyprinus carpio exposed in vivo to well-waters disinfected with sodium hypochlorite (NaClO), chlorine dioxide (ClO2) or peracetic acid (CH3COO2H, PAA), in the absence or presence of standard humic acids (HA). The effects were measured by use of the micronucleus (MN) and the single-cell gel electrophoresis (Comet) assays at different sampling times after a 3-day exposure period. The exposure to chlorine disinfectants without the addition of HA produced a clear toxic effect. Significant cytogenetic damage (i.e. MN induction) was detected in fish populations exposed to both NaClO and ClO2 with humic acids. In the Comet assay, a significant decrease of DNA migration was observed in erythrocytes of specimens after exposure to NaClO-disinfected water without HA. No effects were observed in any other experimental condition. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/16202643/Modulating_effects_of_humic_acids_on_genotoxicity_induced_by_water_disinfectants_in_Cyprinus_carpio_ DB - PRIME DP - Unbound Medicine ER -