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Quantitative thermal sensory testing -- value of testing for both cold and warm sensation detection in evaluation of small fiber neuropathy.
Clin Neurol Neurosurg. 2005 Oct; 107(6):486-90.CN

Abstract

OBJECTIVE

Small fiber neuropathy is a common neurological disorder, often missed or ignored by physicians, since examination and routine nerve conduction studies are usually normal in this condition. Many methods including quantitative thermal sensory testing are currently being used for early detection of this condition, so as to enable timely investigation and treatment. This study was conducted to assess the yield of quantitative thermal sensory testing in diagnosis of small fiber neuropathy.

MATERIAL AND METHODS

We included patients presenting with history suggestive of positive and/or negative sensory symptoms, with normal examination findings, clinically suggestive of small fiber neuropathy, with normal or minimally abnormal routine nerve conduction studies. These patients were subjected to quantitative thermal sensory testing using a Medoc TSA-II Neurosensory analyser at two sites and for two modalities. QST data were compared with those in 120 normal healthy controls.

RESULTS

Twenty-five patients (16 males, 9 females) with mean age 46.8+/-16.6 years (range: 21-75 years) were included in the study. The mean duration of symptoms was 1.6+/-1.6 years (range: 3 months-6 years). Eighteen patients (72%) had abnormal thresholds in at least one modality. Thermal thresholds were normal in 7 out of the 25 patients.

CONCLUSION

This study demonstrates that quantitative thermal sensory testing is a fairly sensitive method for detection of small fiber neuropathy especially in patients with normal routine nerve conduction studies.

Links

Publisher Full Text

Authors+Show Affiliations

Shukla G
Department of Neurology, All India Institute of Medical Sciences, New Delhi 110029, India. garimashukla@hotmail.com
Bhatia M
No affiliation info available
Behari M
No affiliation info available

MeSH

AdultAgedFemaleHumansMaleMiddle AgedNerve FibersNeural ConductionParesthesiaPeripheral NervesPeripheral Nervous System DiseasesSensation DisordersSensory ThresholdsSignal Processing, Computer-AssistedTemperatureThermoreceptors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16202822

Clinical Trial Links

Selective Nerve Stimulation (SNS) Pilot Study

Citation

Shukla, Garima, et al. "Quantitative Thermal Sensory Testing -- Value of Testing for Both Cold and Warm Sensation Detection in Evaluation of Small Fiber Neuropathy." Clinical Neurology and Neurosurgery, vol. 107, no. 6, 2005, pp. 486-90.
Shukla G, Bhatia M, Behari M. Quantitative thermal sensory testing -- value of testing for both cold and warm sensation detection in evaluation of small fiber neuropathy. Clin Neurol Neurosurg. 2005;107(6):486-90.
Shukla, G., Bhatia, M., & Behari, M. (2005). Quantitative thermal sensory testing -- value of testing for both cold and warm sensation detection in evaluation of small fiber neuropathy. Clinical Neurology and Neurosurgery, 107(6), 486-90.
Shukla G, Bhatia M, Behari M. Quantitative Thermal Sensory Testing -- Value of Testing for Both Cold and Warm Sensation Detection in Evaluation of Small Fiber Neuropathy. Clin Neurol Neurosurg. 2005;107(6):486-90. PubMed PMID: 16202822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative thermal sensory testing -- value of testing for both cold and warm sensation detection in evaluation of small fiber neuropathy. AU - Shukla,Garima, AU - Bhatia,Manvir, AU - Behari,Madhuri, PY - 2004/07/21/received PY - 2004/12/07/revised PY - 2004/12/21/accepted PY - 2005/10/6/pubmed PY - 2006/1/7/medline PY - 2005/10/6/entrez SP - 486 EP - 90 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 107 IS - 6 N2 - OBJECTIVE: Small fiber neuropathy is a common neurological disorder, often missed or ignored by physicians, since examination and routine nerve conduction studies are usually normal in this condition. Many methods including quantitative thermal sensory testing are currently being used for early detection of this condition, so as to enable timely investigation and treatment. This study was conducted to assess the yield of quantitative thermal sensory testing in diagnosis of small fiber neuropathy. MATERIAL AND METHODS: We included patients presenting with history suggestive of positive and/or negative sensory symptoms, with normal examination findings, clinically suggestive of small fiber neuropathy, with normal or minimally abnormal routine nerve conduction studies. These patients were subjected to quantitative thermal sensory testing using a Medoc TSA-II Neurosensory analyser at two sites and for two modalities. QST data were compared with those in 120 normal healthy controls. RESULTS: Twenty-five patients (16 males, 9 females) with mean age 46.8+/-16.6 years (range: 21-75 years) were included in the study. The mean duration of symptoms was 1.6+/-1.6 years (range: 3 months-6 years). Eighteen patients (72%) had abnormal thresholds in at least one modality. Thermal thresholds were normal in 7 out of the 25 patients. CONCLUSION: This study demonstrates that quantitative thermal sensory testing is a fairly sensitive method for detection of small fiber neuropathy especially in patients with normal routine nerve conduction studies. SN - 0303-8467 UR - https://www.unboundmedicine.com/medline/citation/16202822/Quantitative_thermal_sensory_testing____value_of_testing_for_both_cold_and_warm_sensation_detection_in_evaluation_of_small_fiber_neuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(04)00220-3 DB - PRIME DP - Unbound Medicine ER -