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A commercial whole blood glucose biosensor with a low sensitivity to hematocrit based on an impregnated porous carbon electrode.
Biosens Bioelectron. 2005 Oct 15; 21(4):581-7.BB

Abstract

Erythrocytes (red blood cells) are a major source of response variation in biosensor electrodes expected to operate in whole blood. Such a blood-to-plasma difference (hematocrit effect) must be minimized for those sensors directed towards the hospital market where wide variations in hematocrit can be seen. Typically, many current glucose sensors demonstrate a decreasing response to the analyte in the presence of increasing hematocrit levels. A sensor electrode for glucose is described which displays a reduced sensitivity to changes in hematocrit. The working electrode comprises a base porous conducting carbon layer, which is impregnated with a mixture including glucose oxidase and a ferrocene redox mediator. The base carbon layer has a void volume of 50%, an average pore diameter of less than 0.1 microm and a thickness of about 20 microm. The interior void volume of the base carbon layer is filled entirely with a substantial proportion of the impregnating mixture such that very little remains on the exterior. The resulting impregnated porous electrode excludes erythrocytes and is consequently capable of operating acceptably in venous, capillary, arterial and neonatal blood over a wide hematocrit range of 20-70%.

Authors+Show Affiliations

MediSense Products, Abbott Diabetes Care, Abbott Laboratories, Range Road, Witney, Oxon OX29 0YL, UK. nigel.forrow@abbott.comNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

16202871

Citation

Forrow, Nigel J., and Simon W. Bayliff. "A Commercial Whole Blood Glucose Biosensor With a Low Sensitivity to Hematocrit Based On an Impregnated Porous Carbon Electrode." Biosensors & Bioelectronics, vol. 21, no. 4, 2005, pp. 581-7.
Forrow NJ, Bayliff SW. A commercial whole blood glucose biosensor with a low sensitivity to hematocrit based on an impregnated porous carbon electrode. Biosens Bioelectron. 2005;21(4):581-7.
Forrow, N. J., & Bayliff, S. W. (2005). A commercial whole blood glucose biosensor with a low sensitivity to hematocrit based on an impregnated porous carbon electrode. Biosensors & Bioelectronics, 21(4), 581-7.
Forrow NJ, Bayliff SW. A Commercial Whole Blood Glucose Biosensor With a Low Sensitivity to Hematocrit Based On an Impregnated Porous Carbon Electrode. Biosens Bioelectron. 2005 Oct 15;21(4):581-7. PubMed PMID: 16202871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A commercial whole blood glucose biosensor with a low sensitivity to hematocrit based on an impregnated porous carbon electrode. AU - Forrow,Nigel J, AU - Bayliff,Simon W, Y1 - 2005/01/19/ PY - 2004/11/24/received PY - 2004/12/15/revised PY - 2004/12/16/accepted PY - 2005/10/6/pubmed PY - 2006/2/16/medline PY - 2005/10/6/entrez SP - 581 EP - 7 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 21 IS - 4 N2 - Erythrocytes (red blood cells) are a major source of response variation in biosensor electrodes expected to operate in whole blood. Such a blood-to-plasma difference (hematocrit effect) must be minimized for those sensors directed towards the hospital market where wide variations in hematocrit can be seen. Typically, many current glucose sensors demonstrate a decreasing response to the analyte in the presence of increasing hematocrit levels. A sensor electrode for glucose is described which displays a reduced sensitivity to changes in hematocrit. The working electrode comprises a base porous conducting carbon layer, which is impregnated with a mixture including glucose oxidase and a ferrocene redox mediator. The base carbon layer has a void volume of 50%, an average pore diameter of less than 0.1 microm and a thickness of about 20 microm. The interior void volume of the base carbon layer is filled entirely with a substantial proportion of the impregnating mixture such that very little remains on the exterior. The resulting impregnated porous electrode excludes erythrocytes and is consequently capable of operating acceptably in venous, capillary, arterial and neonatal blood over a wide hematocrit range of 20-70%. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/16202871/A_commercial_whole_blood_glucose_biosensor_with_a_low_sensitivity_to_hematocrit_based_on_an_impregnated_porous_carbon_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(04)00608-6 DB - PRIME DP - Unbound Medicine ER -