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Impaired oculomotor response inhibition in children of alcoholics: The role of attention deficit hyperactivity disorder.
Drug Alcohol Depend. 2006 Mar 15; 82(1):11-7.DA

Abstract

OBJECTIVE

The aim of the project was to determine whether children at high risk for alcohol use disorder (AUD) are impaired at performing oculomotor response inhibition tasks sensitive to detecting prefrontal cortex dysfunction.

METHODS

Three antisaccade tasks were administered to 67 10-12-year-old children having fathers with AUD and 12 children whose fathers had no psychiatric disorder.

RESULTS

Children of AUD+ fathers performed similar to children of AUD- fathers on measures of response latency and gain to target. Peak velocity discriminated the two groups on only one task. Children of AUD+ fathers exhibited a higher rate of prosaccade errors on the most difficult antisaccade task. Within the AUD+ group of men, offspring who qualified for attention deficit hyperactivity disorder (ADHD; N = 13) exhibited more response suppression errors than children without ADHD on two of three tasks. No differences were observed between children without ADHD whose fathers either qualified for AUD+ or had no psychiatric disorder.

CONCLUSION

Inhibiting a response to a prepotent stimulus in children of AUD+ fathers is circumscribed to ADHD youths. These findings suggest that frontal-striatal mechanisms may underlie the risk for AUD among ADHD children.

Authors+Show Affiliations

Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA, USA. meh1+@pitt.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16203110

Citation

Habeych, Miguel E., et al. "Impaired Oculomotor Response Inhibition in Children of Alcoholics: the Role of Attention Deficit Hyperactivity Disorder." Drug and Alcohol Dependence, vol. 82, no. 1, 2006, pp. 11-7.
Habeych ME, Folan MM, Luna B, et al. Impaired oculomotor response inhibition in children of alcoholics: The role of attention deficit hyperactivity disorder. Drug Alcohol Depend. 2006;82(1):11-7.
Habeych, M. E., Folan, M. M., Luna, B., & Tarter, R. E. (2006). Impaired oculomotor response inhibition in children of alcoholics: The role of attention deficit hyperactivity disorder. Drug and Alcohol Dependence, 82(1), 11-7.
Habeych ME, et al. Impaired Oculomotor Response Inhibition in Children of Alcoholics: the Role of Attention Deficit Hyperactivity Disorder. Drug Alcohol Depend. 2006 Mar 15;82(1):11-7. PubMed PMID: 16203110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired oculomotor response inhibition in children of alcoholics: The role of attention deficit hyperactivity disorder. AU - Habeych,Miguel E, AU - Folan,M Margaret, AU - Luna,Beatriz, AU - Tarter,Ralph E, Y1 - 2005/10/03/ PY - 2004/04/05/received PY - 2005/07/13/revised PY - 2005/07/13/accepted PY - 2005/10/6/pubmed PY - 2006/8/11/medline PY - 2005/10/6/entrez SP - 11 EP - 7 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 82 IS - 1 N2 - OBJECTIVE: The aim of the project was to determine whether children at high risk for alcohol use disorder (AUD) are impaired at performing oculomotor response inhibition tasks sensitive to detecting prefrontal cortex dysfunction. METHODS: Three antisaccade tasks were administered to 67 10-12-year-old children having fathers with AUD and 12 children whose fathers had no psychiatric disorder. RESULTS: Children of AUD+ fathers performed similar to children of AUD- fathers on measures of response latency and gain to target. Peak velocity discriminated the two groups on only one task. Children of AUD+ fathers exhibited a higher rate of prosaccade errors on the most difficult antisaccade task. Within the AUD+ group of men, offspring who qualified for attention deficit hyperactivity disorder (ADHD; N = 13) exhibited more response suppression errors than children without ADHD on two of three tasks. No differences were observed between children without ADHD whose fathers either qualified for AUD+ or had no psychiatric disorder. CONCLUSION: Inhibiting a response to a prepotent stimulus in children of AUD+ fathers is circumscribed to ADHD youths. These findings suggest that frontal-striatal mechanisms may underlie the risk for AUD among ADHD children. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/16203110/Impaired_oculomotor_response_inhibition_in_children_of_alcoholics:_The_role_of_attention_deficit_hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(05)00258-9 DB - PRIME DP - Unbound Medicine ER -