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Copper brain homeostasis: role of amyloid precursor protein and prion protein.
IUBMB Life. 2005 Sep; 57(9):645-50.IL

Abstract

The main proteins associated with Alzheimer's and prion diseases (amyloid precursor protein (APP) and prion protein (PrP(C)), respectively, have binding sites for copper and it has therefore been suggested that they play a role in copper metabolism. Here, we review evidence indicating that the copper binding domains (CuBD) of APP and PrP(C) are able to modulate the oxidation state of copper, and prevent neurotoxic effects and memory impairments induced by copper. Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD.

Authors+Show Affiliations

Centro de Regulacion Celular y Patología Joaquin V. Luco (CRCP), MIFAB, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. ninestr@bio.puc.clNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16203684

Citation

Inestrosa, Nibaldo C., et al. "Copper Brain Homeostasis: Role of Amyloid Precursor Protein and Prion Protein." IUBMB Life, vol. 57, no. 9, 2005, pp. 645-50.
Inestrosa NC, Cerpa W, Varela-Nallar L. Copper brain homeostasis: role of amyloid precursor protein and prion protein. IUBMB Life. 2005;57(9):645-50.
Inestrosa, N. C., Cerpa, W., & Varela-Nallar, L. (2005). Copper brain homeostasis: role of amyloid precursor protein and prion protein. IUBMB Life, 57(9), 645-50.
Inestrosa NC, Cerpa W, Varela-Nallar L. Copper Brain Homeostasis: Role of Amyloid Precursor Protein and Prion Protein. IUBMB Life. 2005;57(9):645-50. PubMed PMID: 16203684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper brain homeostasis: role of amyloid precursor protein and prion protein. AU - Inestrosa,Nibaldo C, AU - Cerpa,Waldo, AU - Varela-Nallar,Lorena, PY - 2005/10/6/pubmed PY - 2005/12/13/medline PY - 2005/10/6/entrez SP - 645 EP - 50 JF - IUBMB life JO - IUBMB Life VL - 57 IS - 9 N2 - The main proteins associated with Alzheimer's and prion diseases (amyloid precursor protein (APP) and prion protein (PrP(C)), respectively, have binding sites for copper and it has therefore been suggested that they play a role in copper metabolism. Here, we review evidence indicating that the copper binding domains (CuBD) of APP and PrP(C) are able to modulate the oxidation state of copper, and prevent neurotoxic effects and memory impairments induced by copper. Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD. SN - 1521-6543 UR - https://www.unboundmedicine.com/medline/citation/16203684/Copper_brain_homeostasis:_role_of_amyloid_precursor_protein_and_prion_protein_ L2 - https://doi.org/10.1080/15216540500264620 DB - PRIME DP - Unbound Medicine ER -