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Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala.
Learn Mem. 2005 Sep-Oct; 12(5):527-32.LM

Abstract

Previous findings indicate that the noradrenergic, dopaminergic, and cholinergic innervations of the basolateral amygdala (BLA) modulate memory consolidation. The current study investigated whether memory enhancement induced by post-training intra-BLA infusions of a beta-adrenergic or muscarinic cholinergic agonist requires concurrent activation of dopamine (DA) receptors in the BLA. Rats with implanted BLA cannulae were trained on an inhibitory avoidance (IA) task and, 48 h later, tested for retention. Infusions of the beta-adrenergic agonist clenbuterol into the right BLA, but not the left, enhanced retention, and concurrent infusions of the nonspecific DA receptor antagonist cis-Flupenthixol (Flu) blocked the enhancement. Post-training infusions of the muscarinic agonist oxotremorine into the right BLA also enhanced retention, and concurrent infusions of Flu blocked this effect. Additional experiments investigated whether memory modulation was lateralized to the right BLA. Post-training DA infusions into the right BLA, but not the left, enhanced retention. Post-training infusions of lidocaine or muscimol, which impair retention when infused bilaterally, had no effect when infused unilaterally into either the right or left BLA. These findings, together with earlier work, suggest that the dopaminergic system in the BLA is critically involved in memory modulation induced by noradrenergic and cholinergic influences. Additionally, these findings indicate that the enhancement, but not impairment, of memory consolidation is lateralized to the right BLA.

Authors+Show Affiliations

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. lalumie@musc.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16204205

Citation

Lalumiere, Ryan T., and James L. McGaugh. "Memory Enhancement Induced By Post-training Intrabasolateral Amygdala Infusions of Beta-adrenergic or Muscarinic Agonists Requires Activation of Dopamine Receptors: Involvement of Right, but Not Left, Basolateral Amygdala." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 12, no. 5, 2005, pp. 527-32.
Lalumiere RT, McGaugh JL. Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala. Learn Mem. 2005;12(5):527-32.
Lalumiere, R. T., & McGaugh, J. L. (2005). Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala. Learning & Memory (Cold Spring Harbor, N.Y.), 12(5), 527-32.
Lalumiere RT, McGaugh JL. Memory Enhancement Induced By Post-training Intrabasolateral Amygdala Infusions of Beta-adrenergic or Muscarinic Agonists Requires Activation of Dopamine Receptors: Involvement of Right, but Not Left, Basolateral Amygdala. Learn Mem. 2005 Sep-Oct;12(5):527-32. PubMed PMID: 16204205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala. AU - Lalumiere,Ryan T, AU - McGaugh,James L, PY - 2005/10/6/pubmed PY - 2006/1/24/medline PY - 2005/10/6/entrez SP - 527 EP - 32 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 12 IS - 5 N2 - Previous findings indicate that the noradrenergic, dopaminergic, and cholinergic innervations of the basolateral amygdala (BLA) modulate memory consolidation. The current study investigated whether memory enhancement induced by post-training intra-BLA infusions of a beta-adrenergic or muscarinic cholinergic agonist requires concurrent activation of dopamine (DA) receptors in the BLA. Rats with implanted BLA cannulae were trained on an inhibitory avoidance (IA) task and, 48 h later, tested for retention. Infusions of the beta-adrenergic agonist clenbuterol into the right BLA, but not the left, enhanced retention, and concurrent infusions of the nonspecific DA receptor antagonist cis-Flupenthixol (Flu) blocked the enhancement. Post-training infusions of the muscarinic agonist oxotremorine into the right BLA also enhanced retention, and concurrent infusions of Flu blocked this effect. Additional experiments investigated whether memory modulation was lateralized to the right BLA. Post-training DA infusions into the right BLA, but not the left, enhanced retention. Post-training infusions of lidocaine or muscimol, which impair retention when infused bilaterally, had no effect when infused unilaterally into either the right or left BLA. These findings, together with earlier work, suggest that the dopaminergic system in the BLA is critically involved in memory modulation induced by noradrenergic and cholinergic influences. Additionally, these findings indicate that the enhancement, but not impairment, of memory consolidation is lateralized to the right BLA. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/16204205/Memory_enhancement_induced_by_post_training_intrabasolateral_amygdala_infusions_of_beta_adrenergic_or_muscarinic_agonists_requires_activation_of_dopamine_receptors:_Involvement_of_right_but_not_left_basolateral_amygdala_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16204205/ DB - PRIME DP - Unbound Medicine ER -