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Clinical aspects of coenzyme Q10: an update.

Abstract

PURPOSE OF REVIEW

Coenzyme Q10 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10.

RECENT FINDINGS

Cardiovascular properties of coenzyme Q10 have been further addressed, namely regarding myocardial protection during cardiac surgery, end-stage heart failure, pediatric cardiomyopathy and in cardiopulmonary resuscitation. The vascular aspects of coenzyme Q10 addressing the important field of endothelial function are briefly examined. The controversial issue of the statin/coenzyme Q10 relationship has been investigated in preliminary studies in which the two substances were administered simultaneously. Work on different neurological diseases, involving mitochondrial dysfunction and oxidative stress, highlights some of the neuroprotective mechanisms of coenzyme Q10. A 4-year follow-up on 10 Friedreich's Ataxia patients treated with coenzyme Q10 and vitamin E showed a substantial improvement in cardiac and skeletal muscle bioenergetics and heart function. Mitochondrial dysfunction likely plays a role in the pathophysiology of migraine as well as age-related macular degeneration and a therapy including coenzyme Q10 produced significant improvement. Finally, the effect of coenzyme Q10 was evaluated in the treatment of asthenozoospermia.

SUMMARY

The latest findings highlight the beneficial role of coenzyme Q10 as coadjuvant in the treatment of syndromes, characterized by impaired mitochondrial bioenergetics and increased oxidative stress, which have a high social impact. Besides their clinical significance, these data give further insight into the biochemical mechanisms of coenzyme Q10 activity.

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  • Authors+Show Affiliations

    ,

    Institute of Biochemistry, Polytechnic University of Marche, Via Ranieri, Ancona, Italy. g.littarru@univpm.it

    Source

    MeSH

    Antioxidants
    Cardiovascular Diseases
    Coenzymes
    Friedreich Ataxia
    Humans
    Macular Degeneration
    Migraine Disorders
    Mitochondria
    Oxidative Stress
    Ubiquinone

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16205466

    Citation

    Littarru, Gian Paolo, and Luca Tiano. "Clinical Aspects of Coenzyme Q10: an Update." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 8, no. 6, 2005, pp. 641-6.
    Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005;8(6):641-6.
    Littarru, G. P., & Tiano, L. (2005). Clinical aspects of coenzyme Q10: an update. Current Opinion in Clinical Nutrition and Metabolic Care, 8(6), pp. 641-6.
    Littarru GP, Tiano L. Clinical Aspects of Coenzyme Q10: an Update. Curr Opin Clin Nutr Metab Care. 2005;8(6):641-6. PubMed PMID: 16205466.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical aspects of coenzyme Q10: an update. AU - Littarru,Gian Paolo, AU - Tiano,Luca, PY - 2005/10/6/pubmed PY - 2006/1/27/medline PY - 2005/10/6/entrez SP - 641 EP - 6 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 8 IS - 6 N2 - PURPOSE OF REVIEW: Coenzyme Q10 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10. RECENT FINDINGS: Cardiovascular properties of coenzyme Q10 have been further addressed, namely regarding myocardial protection during cardiac surgery, end-stage heart failure, pediatric cardiomyopathy and in cardiopulmonary resuscitation. The vascular aspects of coenzyme Q10 addressing the important field of endothelial function are briefly examined. The controversial issue of the statin/coenzyme Q10 relationship has been investigated in preliminary studies in which the two substances were administered simultaneously. Work on different neurological diseases, involving mitochondrial dysfunction and oxidative stress, highlights some of the neuroprotective mechanisms of coenzyme Q10. A 4-year follow-up on 10 Friedreich's Ataxia patients treated with coenzyme Q10 and vitamin E showed a substantial improvement in cardiac and skeletal muscle bioenergetics and heart function. Mitochondrial dysfunction likely plays a role in the pathophysiology of migraine as well as age-related macular degeneration and a therapy including coenzyme Q10 produced significant improvement. Finally, the effect of coenzyme Q10 was evaluated in the treatment of asthenozoospermia. SUMMARY: The latest findings highlight the beneficial role of coenzyme Q10 as coadjuvant in the treatment of syndromes, characterized by impaired mitochondrial bioenergetics and increased oxidative stress, which have a high social impact. Besides their clinical significance, these data give further insight into the biochemical mechanisms of coenzyme Q10 activity. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/16205466/Clinical_aspects_of_coenzyme_Q10:_an_update_ L2 - http://Insights.ovid.com/pubmed?pmid=16205466 DB - PRIME DP - Unbound Medicine ER -