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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.
Br J Pharmacol. 2005 Dec; 146(8):1041-59.BJ

Abstract

The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.

Authors+Show Affiliations

Department of Pharmacy, King's College, Franklin-Wilkins Building, London. alessandra.gaeta@kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16205720

Citation

Gaeta, Alessandra, and Robert C. Hider. "The Crucial Role of Metal Ions in Neurodegeneration: the Basis for a Promising Therapeutic Strategy." British Journal of Pharmacology, vol. 146, no. 8, 2005, pp. 1041-59.
Gaeta A, Hider RC. The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br J Pharmacol. 2005;146(8):1041-59.
Gaeta, A., & Hider, R. C. (2005). The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. British Journal of Pharmacology, 146(8), 1041-59.
Gaeta A, Hider RC. The Crucial Role of Metal Ions in Neurodegeneration: the Basis for a Promising Therapeutic Strategy. Br J Pharmacol. 2005;146(8):1041-59. PubMed PMID: 16205720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. AU - Gaeta,Alessandra, AU - Hider,Robert C, PY - 2005/10/6/pubmed PY - 2006/9/15/medline PY - 2005/10/6/entrez SP - 1041 EP - 59 JF - British journal of pharmacology JO - Br. J. Pharmacol. VL - 146 IS - 8 N2 - The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/16205720/The_crucial_role_of_metal_ions_in_neurodegeneration:_the_basis_for_a_promising_therapeutic_strategy_ L2 - https://doi.org/10.1038/sj.bjp.0706416 DB - PRIME DP - Unbound Medicine ER -