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Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men.
Eur J Clin Nutr. 2006 Jan; 60(1):129-35.EJ

Abstract

OBJECTIVE

To study dietary intake and serum concentrations of isoflavones in order to provide relative validation of isoflavone intake estimates from the Scottish Collaborative Group - Food-Frequency Questionnaire (SCG-FFQ).

DESIGN

Validation study.

SETTING

Southern Scotland.

METHOD

Dietary intake of isoflavones was estimated using the semiquantitative SCG-FFQ and rank correlation and Kappa statistics were used for the relative validation of intakes against serum isoflavone concentrations in 203 male participants who were population controls in a case-control study of diet and prostate cancer.

RESULTS

The median intake of isoflavones (daidzein and genistein) was 1.0mg/day (l-QR 0.6-1.8). The median serum concentration of genistein was 33.79 nmol/l (I-QR 14.12-64.93), nearly twice that of daidzein (18.00 nmol/l, I-QR 8.26-29.45). Equol was detected in 49% of subjects; in these subjects the median was 0.67 nmol/l (I-QR 0.34-1.51). Isoflavone intake was significantly correlated with serum concentrations of daidzein (p = 0.24, P = 0.001), genistein (p = 0.26, P < 0.001) and total isoflavonoids (sum of daidzein, genistein and equol) (p = 0.27, P < 0.001). Whereas values for weighted Kappa ranged from 0.16 (P = 0.002) for daidzein and equol combined to 0.22 (P < 0.001) for genistein.

CONCLUSIONS

These results demonstrate the suitability of the SCG-FFQ to rank usual isoflavone intakes in older Scottish men, a population observed to have low consumption of soy foods.

Authors+Show Affiliations

Public Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK. charlotte.heald@ed.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

16205743

Citation

Heald, C L., et al. "Phyto-oestrogen Intake in Scottish Men: Use of Serum to Validate a Self-administered Food-frequency Questionnaire in Older Men." European Journal of Clinical Nutrition, vol. 60, no. 1, 2006, pp. 129-35.
Heald CL, Bolton-Smith C, Ritchie MR, et al. Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men. Eur J Clin Nutr. 2006;60(1):129-35.
Heald, C. L., Bolton-Smith, C., Ritchie, M. R., Morton, M. S., & Alexander, F. E. (2006). Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men. European Journal of Clinical Nutrition, 60(1), 129-35.
Heald CL, et al. Phyto-oestrogen Intake in Scottish Men: Use of Serum to Validate a Self-administered Food-frequency Questionnaire in Older Men. Eur J Clin Nutr. 2006;60(1):129-35. PubMed PMID: 16205743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men. AU - Heald,C L, AU - Bolton-Smith,C, AU - Ritchie,M R, AU - Morton,M S, AU - Alexander,F E, PY - 2005/10/6/pubmed PY - 2006/4/21/medline PY - 2005/10/6/entrez SP - 129 EP - 35 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 1 N2 - OBJECTIVE: To study dietary intake and serum concentrations of isoflavones in order to provide relative validation of isoflavone intake estimates from the Scottish Collaborative Group - Food-Frequency Questionnaire (SCG-FFQ). DESIGN: Validation study. SETTING: Southern Scotland. METHOD: Dietary intake of isoflavones was estimated using the semiquantitative SCG-FFQ and rank correlation and Kappa statistics were used for the relative validation of intakes against serum isoflavone concentrations in 203 male participants who were population controls in a case-control study of diet and prostate cancer. RESULTS: The median intake of isoflavones (daidzein and genistein) was 1.0mg/day (l-QR 0.6-1.8). The median serum concentration of genistein was 33.79 nmol/l (I-QR 14.12-64.93), nearly twice that of daidzein (18.00 nmol/l, I-QR 8.26-29.45). Equol was detected in 49% of subjects; in these subjects the median was 0.67 nmol/l (I-QR 0.34-1.51). Isoflavone intake was significantly correlated with serum concentrations of daidzein (p = 0.24, P = 0.001), genistein (p = 0.26, P < 0.001) and total isoflavonoids (sum of daidzein, genistein and equol) (p = 0.27, P < 0.001). Whereas values for weighted Kappa ranged from 0.16 (P = 0.002) for daidzein and equol combined to 0.22 (P < 0.001) for genistein. CONCLUSIONS: These results demonstrate the suitability of the SCG-FFQ to rank usual isoflavone intakes in older Scottish men, a population observed to have low consumption of soy foods. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16205743/Phyto_oestrogen_intake_in_Scottish_men:_use_of_serum_to_validate_a_self_administered_food_frequency_questionnaire_in_older_men_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602277 DB - PRIME DP - Unbound Medicine ER -