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3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex.
Synapse 2005; 58(4):229-35S

Abstract

3,4-Methylenedioxymethamphetamine (MDMA), an amphetamine analog, has been shown recently to increase the release of acetylcholine (ACh) in the prefrontal cortex (PFC). The present study further characterizes the stimulatory effect of MDMA on cortical ACh release and examines the role of serotonin (5-HT) and dopamine (DA) receptors in this response. The extracellular concentration of ACh was increased dose-dependently and similarly by the (+) and (-) enantiomers of MDMA (5 and 20 mg/kg, i.p.). The systemic administration of the 5-HT(4) antagonist SDZ 205,557 (1 mg/kg, i.p.), but not the 5-HT(2A/2B/2C) antagonist LY-53,857 (3 mg/kg, i.p.), significantly decreased cortical ACh release induced by MDMA. The MDMA-induced increase in the extracellular concentration of ACh also was significantly blunted in rats treated with the D(1) receptor antagonist SCH 23390 (0.5 mg/kg, i.p.). The extent to which the coadministration of SDZ 205,557 and SCH 23390 suppressed the MDMA-induced release of ACh in the PFC was no greater than that produced by either antagonist alone. These results suggest that the 5-HT(4) and D(1) receptor subtypes contribute to the mechanism by which MDMA increases ACh release in the PFC.

Authors+Show Affiliations

College of Pharmacy, University of Cincinnati, OH 45267, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16206181

Citation

Nair, Sunila G., and Gary A. Gudelsky. "3,4-Methylenedioxymethamphetamine (MDMA) Enhances the Release of Acetylcholine By 5-HT4 and D1 Receptor Mechanisms in the Rat Prefrontal Cortex." Synapse (New York, N.Y.), vol. 58, no. 4, 2005, pp. 229-35.
Nair SG, Gudelsky GA. 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. Synapse. 2005;58(4):229-35.
Nair, S. G., & Gudelsky, G. A. (2005). 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. Synapse (New York, N.Y.), 58(4), pp. 229-35.
Nair SG, Gudelsky GA. 3,4-Methylenedioxymethamphetamine (MDMA) Enhances the Release of Acetylcholine By 5-HT4 and D1 Receptor Mechanisms in the Rat Prefrontal Cortex. Synapse. 2005 Dec 15;58(4):229-35. PubMed PMID: 16206181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. AU - Nair,Sunila G, AU - Gudelsky,Gary A, PY - 2005/10/6/pubmed PY - 2006/1/19/medline PY - 2005/10/6/entrez SP - 229 EP - 35 JF - Synapse (New York, N.Y.) JO - Synapse VL - 58 IS - 4 N2 - 3,4-Methylenedioxymethamphetamine (MDMA), an amphetamine analog, has been shown recently to increase the release of acetylcholine (ACh) in the prefrontal cortex (PFC). The present study further characterizes the stimulatory effect of MDMA on cortical ACh release and examines the role of serotonin (5-HT) and dopamine (DA) receptors in this response. The extracellular concentration of ACh was increased dose-dependently and similarly by the (+) and (-) enantiomers of MDMA (5 and 20 mg/kg, i.p.). The systemic administration of the 5-HT(4) antagonist SDZ 205,557 (1 mg/kg, i.p.), but not the 5-HT(2A/2B/2C) antagonist LY-53,857 (3 mg/kg, i.p.), significantly decreased cortical ACh release induced by MDMA. The MDMA-induced increase in the extracellular concentration of ACh also was significantly blunted in rats treated with the D(1) receptor antagonist SCH 23390 (0.5 mg/kg, i.p.). The extent to which the coadministration of SDZ 205,557 and SCH 23390 suppressed the MDMA-induced release of ACh in the PFC was no greater than that produced by either antagonist alone. These results suggest that the 5-HT(4) and D(1) receptor subtypes contribute to the mechanism by which MDMA increases ACh release in the PFC. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/16206181/34_Methylenedioxymethamphetamine__MDMA__enhances_the_release_of_acetylcholine_by_5_HT4_and_D1_receptor_mechanisms_in_the_rat_prefrontal_cortex_ L2 - https://doi.org/10.1002/syn.20202 DB - PRIME DP - Unbound Medicine ER -