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Ruthenium-catalyzed reactions--a treasure trove of atom-economic transformations.
Angew Chem Int Ed Engl. 2005 Oct 21; 44(41):6630-66.AC

Abstract

The demand for new chemicals spanning the fields of health care to materials science combined with the pressure to produce these substances in an environmentally benign fashion pose great challenges to the synthetic chemical community. The maximization of synthetic efficiency by the conversion of simple building blocks into complex targets remains a fundamental goal. In this context, ruthenium complexes catalyze a number of non-metathesis conversions and allow the rapid assembly of complex molecules with high selectivity and atom economy. These complexes often exhibit unusual reactivity. Careful consideration of the mechanistic underpinnings of the transformations can lead to the design of new reactions and the discovery of new reactivity.

Authors+Show Affiliations

Trost BM
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. bmtrost@stanford.edu
Frederiksen MU
No affiliation info available
Rudd MT
No affiliation info available

MeSH

AlkenesAlkynesCatalysisCyclizationEstersKetonesMolecular StructureOrganometallic CompoundsOxidation-ReductionRutheniumStereoisomerism

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

16206300

Citation

Trost, Barry M., et al. "Ruthenium-catalyzed Reactions--a Treasure Trove of Atom-economic Transformations." Angewandte Chemie (International Ed. in English), vol. 44, no. 41, 2005, pp. 6630-66.
Trost BM, Frederiksen MU, Rudd MT. Ruthenium-catalyzed reactions--a treasure trove of atom-economic transformations. Angew Chem Int Ed Engl. 2005;44(41):6630-66.
Trost, B. M., Frederiksen, M. U., & Rudd, M. T. (2005). Ruthenium-catalyzed reactions--a treasure trove of atom-economic transformations. Angewandte Chemie (International Ed. in English), 44(41), 6630-66.
Trost BM, Frederiksen MU, Rudd MT. Ruthenium-catalyzed Reactions--a Treasure Trove of Atom-economic Transformations. Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6630-66. PubMed PMID: 16206300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ruthenium-catalyzed reactions--a treasure trove of atom-economic transformations. AU - Trost,Barry M, AU - Frederiksen,Mathias U, AU - Rudd,Michael T, PY - 2005/10/6/pubmed PY - 2006/10/13/medline PY - 2005/10/6/entrez SP - 6630 EP - 66 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 44 IS - 41 N2 - The demand for new chemicals spanning the fields of health care to materials science combined with the pressure to produce these substances in an environmentally benign fashion pose great challenges to the synthetic chemical community. The maximization of synthetic efficiency by the conversion of simple building blocks into complex targets remains a fundamental goal. In this context, ruthenium complexes catalyze a number of non-metathesis conversions and allow the rapid assembly of complex molecules with high selectivity and atom economy. These complexes often exhibit unusual reactivity. Careful consideration of the mechanistic underpinnings of the transformations can lead to the design of new reactions and the discovery of new reactivity. SN - 1433-7851 UR - https://www.unboundmedicine.com/medline/citation/16206300/Ruthenium_catalyzed_reactions__a_treasure_trove_of_atom_economic_transformations_ DB - PRIME DP - Unbound Medicine ER -