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[Comparative effects of carvedilol, losartan and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats].
Zhonghua Nei Ke Za Zhi. 2001 Dec; 40(12):811-4.ZN

Abstract

OBJECTIVE

To compare the effects of carvedilol, losartan and their combination in preventing from left ventricular remodeling (LVRM) after acute myocardial infarction(AMI) in rats.

METHODS

Twenty-four hours after ligating left coronary artery, 100 surviving AMI female SD rats were randomly assigned to: (1) AMI control (n = 25), (2) carvedilol (1 mg x kg(-1) x d(-1)) (C1) (n = 25); (3) losartan (3 mg x kg(-1) x d(-1)) (L3)(n = 25); and (4) carvedilol (1 mg x kg(-1) x d(-1)) + losartan (3 mg x kg(-1) x d(-1)) (C1 + L3) (n = 25) groups. Sham-operated group (n = 17) were selected randomly as non-infarction control. After 4 weeks of therapy with the drugs by gastric gavage, hemodynamic studies were performed, then the rat hearts were fixed and pathologically analyzed. Exclusive of the rats with MI size < 35% or > 55%, complete data were obtained in 65 rats, which were comprised of AMI control (n = 13), C1 (n = 12), L3 (n = 13), C1 + L3 (n = 14) and sham-operated (n = 13) groups.

RESULTS

There were no significant differences in MI size among the four AMI groups (45.8% - 46.7%, P > 0.05) . Compared with sham-operated group, Left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), weight (LVW), septal thickness (STh) and right ventricular weight (RVW) were all significantly increased (all P < 0.01) in AMI group, while the left ventricular pressure maximal rate of rise and fall (dp/dt) were significantly decreased (all P < 0.01). In comparison with AMI group, LVEDP, LVV, LVW, STh and RVW were all significantly decreased (all P < 0.01), while +/- dp/dt and +/- dp/dt/LVSP were significantly increased (P < 0.05 - 0.01) in all three therapy groups, with LVEDP decreasing more in the combination and L3 groups than in C1 group (P < 0.05 - 0.01) and STh decreasing more in the combination group than in C1 group (P < 0.01), but there were no significant differences in other variables among the three therapy groups.

CONCLUSION

Carvedilol, losartan and their combination all can prevent from LVRM after AMI in rats, improve hemodynamics and LV function, with the combination superior.

Authors+Show Affiliations

Cardiovascular Institute, Fuwai Heart Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100037, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

chi

PubMed ID

16206669

Citation

Yang, Y, et al. "[Comparative Effects of Carvedilol, Losartan and Their Combination in Preventing Left Ventricular Remodeling After Acute Myocardial Infarction in Rats]." Zhonghua Nei Ke Za Zhi, vol. 40, no. 12, 2001, pp. 811-4.
Yang Y, Tang Y, Ruan Y, et al. [Comparative effects of carvedilol, losartan and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats]. Zhonghua Nei Ke Za Zhi. 2001;40(12):811-4.
Yang, Y., Tang, Y., Ruan, Y., Li, Y., Gao, R., & Chen, Z. (2001). [Comparative effects of carvedilol, losartan and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats]. Zhonghua Nei Ke Za Zhi, 40(12), 811-4.
Yang Y, et al. [Comparative Effects of Carvedilol, Losartan and Their Combination in Preventing Left Ventricular Remodeling After Acute Myocardial Infarction in Rats]. Zhonghua Nei Ke Za Zhi. 2001;40(12):811-4. PubMed PMID: 16206669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative effects of carvedilol, losartan and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats]. AU - Yang,Y, AU - Tang,Y, AU - Ruan,Y, AU - Li,Y, AU - Gao,R, AU - Chen,Z, PY - 2005/10/7/pubmed PY - 2006/6/10/medline PY - 2005/10/7/entrez SP - 811 EP - 4 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 40 IS - 12 N2 - OBJECTIVE: To compare the effects of carvedilol, losartan and their combination in preventing from left ventricular remodeling (LVRM) after acute myocardial infarction(AMI) in rats. METHODS: Twenty-four hours after ligating left coronary artery, 100 surviving AMI female SD rats were randomly assigned to: (1) AMI control (n = 25), (2) carvedilol (1 mg x kg(-1) x d(-1)) (C1) (n = 25); (3) losartan (3 mg x kg(-1) x d(-1)) (L3)(n = 25); and (4) carvedilol (1 mg x kg(-1) x d(-1)) + losartan (3 mg x kg(-1) x d(-1)) (C1 + L3) (n = 25) groups. Sham-operated group (n = 17) were selected randomly as non-infarction control. After 4 weeks of therapy with the drugs by gastric gavage, hemodynamic studies were performed, then the rat hearts were fixed and pathologically analyzed. Exclusive of the rats with MI size < 35% or > 55%, complete data were obtained in 65 rats, which were comprised of AMI control (n = 13), C1 (n = 12), L3 (n = 13), C1 + L3 (n = 14) and sham-operated (n = 13) groups. RESULTS: There were no significant differences in MI size among the four AMI groups (45.8% - 46.7%, P > 0.05) . Compared with sham-operated group, Left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), weight (LVW), septal thickness (STh) and right ventricular weight (RVW) were all significantly increased (all P < 0.01) in AMI group, while the left ventricular pressure maximal rate of rise and fall (dp/dt) were significantly decreased (all P < 0.01). In comparison with AMI group, LVEDP, LVV, LVW, STh and RVW were all significantly decreased (all P < 0.01), while +/- dp/dt and +/- dp/dt/LVSP were significantly increased (P < 0.05 - 0.01) in all three therapy groups, with LVEDP decreasing more in the combination and L3 groups than in C1 group (P < 0.05 - 0.01) and STh decreasing more in the combination group than in C1 group (P < 0.01), but there were no significant differences in other variables among the three therapy groups. CONCLUSION: Carvedilol, losartan and their combination all can prevent from LVRM after AMI in rats, improve hemodynamics and LV function, with the combination superior. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/16206669/[Comparative_effects_of_carvedilol_losartan_and_their_combination_in_preventing_left_ventricular_remodeling_after_acute_myocardial_infarction_in_rats]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -