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Pharmacokinetics of azithromycin after i.v. and i.m. administration to sheep.
J Vet Pharmacol Ther. 2005 Oct; 28(5):475-9.JV

Abstract

The pharmacokinetics (PK) of azithromycin after i.v. and i.m. injection at a single dosage of 20 mg/kg bodyweight was studied in sheep. Blood samples were collected from the jugular vein until 120 h after dosing for both routes. Plasma concentrations of azithromycin were determined by bioassay. The plasma concentration-time data of azithromycin best fitted a three-compartment model after i.v. administration and a two-compartment model with first-order absorption after i.m. administration. The elimination half-life (t(1/2lambdaz)) was 47.70 +/- 7.49 h after i.v. administration and 61.29 +/- 13.86 h after i.m. administration. Clearance value after i.v. dosing was 0.52 +/- 0.08 L/kg.h. After i.m. administration a peak azithromycin concentration (C(max)) of 1.26 +/- 0.19 mg/L was achieved at 1.24 +/- 0.31 h (t(max)). Area under the curve (AUC) were 38.85 +/- 5.83 mg.h/L and 36.03 +/- 1.52 mg.h/L after i.v. and i.m. administration respectively. Bioavailability obtained after i.m. administration was 94.08 +/- 11.56%. The high tolerability of this i.m. preparation and the favourable PK behaviour such as the long half-life and high bioavailability make azithromycin likely to be effective in sheep.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, Murcia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16207311

Citation

Cárceles, C M., et al. "Pharmacokinetics of Azithromycin After I.v. and I.m. Administration to Sheep." Journal of Veterinary Pharmacology and Therapeutics, vol. 28, no. 5, 2005, pp. 475-9.
Cárceles CM, Font A, Escudero E, et al. Pharmacokinetics of azithromycin after i.v. and i.m. administration to sheep. J Vet Pharmacol Ther. 2005;28(5):475-9.
Cárceles, C. M., Font, A., Escudero, E., Espuny, A., Marín, P., & Fernández-Varón, E. (2005). Pharmacokinetics of azithromycin after i.v. and i.m. administration to sheep. Journal of Veterinary Pharmacology and Therapeutics, 28(5), 475-9.
Cárceles CM, et al. Pharmacokinetics of Azithromycin After I.v. and I.m. Administration to Sheep. J Vet Pharmacol Ther. 2005;28(5):475-9. PubMed PMID: 16207311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of azithromycin after i.v. and i.m. administration to sheep. AU - Cárceles,C M, AU - Font,A, AU - Escudero,E, AU - Espuny,A, AU - Marín,P, AU - Fernández-Varón,E, PY - 2005/10/7/pubmed PY - 2005/12/13/medline PY - 2005/10/7/entrez SP - 475 EP - 9 JF - Journal of veterinary pharmacology and therapeutics JO - J Vet Pharmacol Ther VL - 28 IS - 5 N2 - The pharmacokinetics (PK) of azithromycin after i.v. and i.m. injection at a single dosage of 20 mg/kg bodyweight was studied in sheep. Blood samples were collected from the jugular vein until 120 h after dosing for both routes. Plasma concentrations of azithromycin were determined by bioassay. The plasma concentration-time data of azithromycin best fitted a three-compartment model after i.v. administration and a two-compartment model with first-order absorption after i.m. administration. The elimination half-life (t(1/2lambdaz)) was 47.70 +/- 7.49 h after i.v. administration and 61.29 +/- 13.86 h after i.m. administration. Clearance value after i.v. dosing was 0.52 +/- 0.08 L/kg.h. After i.m. administration a peak azithromycin concentration (C(max)) of 1.26 +/- 0.19 mg/L was achieved at 1.24 +/- 0.31 h (t(max)). Area under the curve (AUC) were 38.85 +/- 5.83 mg.h/L and 36.03 +/- 1.52 mg.h/L after i.v. and i.m. administration respectively. Bioavailability obtained after i.m. administration was 94.08 +/- 11.56%. The high tolerability of this i.m. preparation and the favourable PK behaviour such as the long half-life and high bioavailability make azithromycin likely to be effective in sheep. SN - 0140-7783 UR - https://www.unboundmedicine.com/medline/citation/16207311/Pharmacokinetics_of_azithromycin_after_i_v__and_i_m__administration_to_sheep_ L2 - https://doi.org/10.1111/j.1365-2885.2005.00680.x DB - PRIME DP - Unbound Medicine ER -