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[Effect of protective ventilation and open lung strategy on extravascular lung water in rabbits with acute respiratory distress syndrome].
Zhonghua Jie He He Hu Xi Za Zhi. 2005 Sep; 28(9):615-8.ZJ

Abstract

OBJECTIVE

To study the effect of protective ventilation and open lung strategy on extravascular lung water index (EVLWI) in rabbits with acute respiratory distress syndrome (ARDS).

METHODS

Saline-lavaged, anesthetized ARDS rabbits were divided into (1) a moderate tidal volume (V(T)) zero positive end-expiratory pressure (PEEP) group (MVZP group): V(T) 12 ml/kg, PEEP 0 cm H2O; (2) a low V(T) zero PEEP group (LVZP group): V(T) 6 ml/kg, PEEP 0 cm H2O; (3) a low V(T) best PEEP group (LVBP group): V(T) 6 ml/kg, PEEP 10 cm H2O; (4) a low V(T) best PEEP + sustained inflation (SI) group (LVBP + SI group): V(T) 6 ml/kg, PEEP 10 cm H2O + SI. EVLWI was measured by single indicator thermodilution technique at baseline, 0, 1, 2 and 3 h.

RESULTS

In the MVZP, LVZP, LVBP, and LVBP + SI groups, EVLWI in the ARDS model [(22.3 +/- 5.6), (20.0 +/- 3.8), (25.7 +/- 9.7), (22.5 +/- 6.2) ml/kg, respectively] was significantly higher than those at baseline [(11.3 +/- 2.4), (10.2 +/- 2.4), (10.3 +/- 4.6), (9.7 +/- 2.3) ml/kg, respectively, all P < 0.05]. In the MVZP group, EVLWI at 2 h and 3 h [(32.0 +/- 12.2), (36.2 +/- 12.4) ml/kg] was higher than that of 0 h [(22.3 +/- 5.6) ml/kg, P < 0.05]. In the LVZP group EVLWI at 2 h and 3 h [(27.8 +/- 12.9), (30.3 +/- 13.0) ml/kg] was also higher than that of 0 h [(20.0 +/- 3.8) ml/kg, P < 0.05]. In the LVBP group, EVLWI at 1 h was (18.5 +/- 8.1) ml/kg and was lower than that of 0 h [(25.7 +/- 9.7) ml/kg, P = 0.027]. In the LVBP + SI group, EVLWI at 1, 2, 3 h [(16.8 +/- 6.5), (18.0 +/- 7.1), (15.7 +/- 2.7) ml/kg] was lower than that of 0 h [(22.5 +/- 6.2) ml/kg, all P < 0.05]. There was significant difference among the four groups at 1 h and 3 h (all P < 0.05). At 1 h and 3 h, compared with MVZP group, EVLWI of the LVBP and the LVBP + SI groups were significantly decreased (all P < 0.05). At 3 h, compared with the EVLWI of the LVZP group, EVLWI of the LVBP + SI group was significantly decreased (P < 0.05).

CONCLUSION

Lung protective ventilation and open lung strategy could decrease EVLWI.

Authors+Show Affiliations

Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16207430

Citation

Chen, Yong-ming, et al. "[Effect of Protective Ventilation and Open Lung Strategy On Extravascular Lung Water in Rabbits With Acute Respiratory Distress Syndrome]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 28, no. 9, 2005, pp. 615-8.
Chen YM, Yang Y, Qiu HB, et al. [Effect of protective ventilation and open lung strategy on extravascular lung water in rabbits with acute respiratory distress syndrome]. Zhonghua Jie He He Hu Xi Za Zhi. 2005;28(9):615-8.
Chen, Y. M., Yang, Y., Qiu, H. B., Li, J. Q., Huang, Y. Z., & Xu, X. T. (2005). [Effect of protective ventilation and open lung strategy on extravascular lung water in rabbits with acute respiratory distress syndrome]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 28(9), 615-8.
Chen YM, et al. [Effect of Protective Ventilation and Open Lung Strategy On Extravascular Lung Water in Rabbits With Acute Respiratory Distress Syndrome]. Zhonghua Jie He He Hu Xi Za Zhi. 2005;28(9):615-8. PubMed PMID: 16207430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of protective ventilation and open lung strategy on extravascular lung water in rabbits with acute respiratory distress syndrome]. AU - Chen,Yong-ming, AU - Yang,Yi, AU - Qiu,Hai-bo, AU - Li,Jia-qiong, AU - Huang,Ying-zi, AU - Xu,Xiao-ting, PY - 2005/10/7/pubmed PY - 2010/9/3/medline PY - 2005/10/7/entrez SP - 615 EP - 8 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 28 IS - 9 N2 - OBJECTIVE: To study the effect of protective ventilation and open lung strategy on extravascular lung water index (EVLWI) in rabbits with acute respiratory distress syndrome (ARDS). METHODS: Saline-lavaged, anesthetized ARDS rabbits were divided into (1) a moderate tidal volume (V(T)) zero positive end-expiratory pressure (PEEP) group (MVZP group): V(T) 12 ml/kg, PEEP 0 cm H2O; (2) a low V(T) zero PEEP group (LVZP group): V(T) 6 ml/kg, PEEP 0 cm H2O; (3) a low V(T) best PEEP group (LVBP group): V(T) 6 ml/kg, PEEP 10 cm H2O; (4) a low V(T) best PEEP + sustained inflation (SI) group (LVBP + SI group): V(T) 6 ml/kg, PEEP 10 cm H2O + SI. EVLWI was measured by single indicator thermodilution technique at baseline, 0, 1, 2 and 3 h. RESULTS: In the MVZP, LVZP, LVBP, and LVBP + SI groups, EVLWI in the ARDS model [(22.3 +/- 5.6), (20.0 +/- 3.8), (25.7 +/- 9.7), (22.5 +/- 6.2) ml/kg, respectively] was significantly higher than those at baseline [(11.3 +/- 2.4), (10.2 +/- 2.4), (10.3 +/- 4.6), (9.7 +/- 2.3) ml/kg, respectively, all P < 0.05]. In the MVZP group, EVLWI at 2 h and 3 h [(32.0 +/- 12.2), (36.2 +/- 12.4) ml/kg] was higher than that of 0 h [(22.3 +/- 5.6) ml/kg, P < 0.05]. In the LVZP group EVLWI at 2 h and 3 h [(27.8 +/- 12.9), (30.3 +/- 13.0) ml/kg] was also higher than that of 0 h [(20.0 +/- 3.8) ml/kg, P < 0.05]. In the LVBP group, EVLWI at 1 h was (18.5 +/- 8.1) ml/kg and was lower than that of 0 h [(25.7 +/- 9.7) ml/kg, P = 0.027]. In the LVBP + SI group, EVLWI at 1, 2, 3 h [(16.8 +/- 6.5), (18.0 +/- 7.1), (15.7 +/- 2.7) ml/kg] was lower than that of 0 h [(22.5 +/- 6.2) ml/kg, all P < 0.05]. There was significant difference among the four groups at 1 h and 3 h (all P < 0.05). At 1 h and 3 h, compared with MVZP group, EVLWI of the LVBP and the LVBP + SI groups were significantly decreased (all P < 0.05). At 3 h, compared with the EVLWI of the LVZP group, EVLWI of the LVBP + SI group was significantly decreased (P < 0.05). CONCLUSION: Lung protective ventilation and open lung strategy could decrease EVLWI. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/16207430/[Effect_of_protective_ventilation_and_open_lung_strategy_on_extravascular_lung_water_in_rabbits_with_acute_respiratory_distress_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2005&amp;vol=28&amp;issue=9&amp;fpage=615 DB - PRIME DP - Unbound Medicine ER -