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Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism.
Am J Epidemiol 2005; 162(10):975-82AJ

Abstract

Methods for formal comparison of competing risks may clarify uncertainties about the associations of atherosclerotic risk factors with the development of venous thromboembolism (VTE). For a median of 20.1 years, the Physicians' Health Study (1982-2003) followed 18,662 US male physicians with no prior myocardial infarction, stroke, VTE, or cancer and for whom reported risk factor information was available at baseline. The authors used methods of competing risk survival analysis to compare relative hazard rates associated with age, hypertension, elevated cholesterol, diabetes, cigarette smoking, alcohol consumption, exercise frequency, body mass index, and height. During follow-up, coronary heart disease (CHD) occurred first in 1,348 men, stroke in 902 men, and VTE in 358 men. Incidence of all three outcomes increased with age, but the rate of increase was strongest for stroke. Hypertension, elevated cholesterol, diabetes, and smoking were associated with increased rates of CHD and stroke, with comparable magnitudes, but had no association with VTE. Conversely, higher body mass index was more strongly associated with risk of VTE than of either CHD or stroke, and taller men had a significantly increased risk of VTE but a lower risk of CHD. CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE.

Authors+Show Affiliations

Division of Preventive Medicine and the Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. rglynn@rics.bwh.harvard.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16207808

Citation

Glynn, Robert J., and Bernard Rosner. "Comparison of Risk Factors for the Competing Risks of Coronary Heart Disease, Stroke, and Venous Thromboembolism." American Journal of Epidemiology, vol. 162, no. 10, 2005, pp. 975-82.
Glynn RJ, Rosner B. Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. Am J Epidemiol. 2005;162(10):975-82.
Glynn, R. J., & Rosner, B. (2005). Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. American Journal of Epidemiology, 162(10), pp. 975-82.
Glynn RJ, Rosner B. Comparison of Risk Factors for the Competing Risks of Coronary Heart Disease, Stroke, and Venous Thromboembolism. Am J Epidemiol. 2005 Nov 15;162(10):975-82. PubMed PMID: 16207808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. AU - Glynn,Robert J, AU - Rosner,Bernard, Y1 - 2005/10/05/ PY - 2005/10/7/pubmed PY - 2006/1/20/medline PY - 2005/10/7/entrez SP - 975 EP - 82 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 10 N2 - Methods for formal comparison of competing risks may clarify uncertainties about the associations of atherosclerotic risk factors with the development of venous thromboembolism (VTE). For a median of 20.1 years, the Physicians' Health Study (1982-2003) followed 18,662 US male physicians with no prior myocardial infarction, stroke, VTE, or cancer and for whom reported risk factor information was available at baseline. The authors used methods of competing risk survival analysis to compare relative hazard rates associated with age, hypertension, elevated cholesterol, diabetes, cigarette smoking, alcohol consumption, exercise frequency, body mass index, and height. During follow-up, coronary heart disease (CHD) occurred first in 1,348 men, stroke in 902 men, and VTE in 358 men. Incidence of all three outcomes increased with age, but the rate of increase was strongest for stroke. Hypertension, elevated cholesterol, diabetes, and smoking were associated with increased rates of CHD and stroke, with comparable magnitudes, but had no association with VTE. Conversely, higher body mass index was more strongly associated with risk of VTE than of either CHD or stroke, and taller men had a significantly increased risk of VTE but a lower risk of CHD. CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16207808/Comparison_of_risk_factors_for_the_competing_risks_of_coronary_heart_disease_stroke_and_venous_thromboembolism_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi309 DB - PRIME DP - Unbound Medicine ER -