Tags

Type your tag names separated by a space and hit enter

Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism.

Abstract

Methods for formal comparison of competing risks may clarify uncertainties about the associations of atherosclerotic risk factors with the development of venous thromboembolism (VTE). For a median of 20.1 years, the Physicians' Health Study (1982-2003) followed 18,662 US male physicians with no prior myocardial infarction, stroke, VTE, or cancer and for whom reported risk factor information was available at baseline. The authors used methods of competing risk survival analysis to compare relative hazard rates associated with age, hypertension, elevated cholesterol, diabetes, cigarette smoking, alcohol consumption, exercise frequency, body mass index, and height. During follow-up, coronary heart disease (CHD) occurred first in 1,348 men, stroke in 902 men, and VTE in 358 men. Incidence of all three outcomes increased with age, but the rate of increase was strongest for stroke. Hypertension, elevated cholesterol, diabetes, and smoking were associated with increased rates of CHD and stroke, with comparable magnitudes, but had no association with VTE. Conversely, higher body mass index was more strongly associated with risk of VTE than of either CHD or stroke, and taller men had a significantly increased risk of VTE but a lower risk of CHD. CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine and the Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. rglynn@rics.bwh.harvard.edu

    Source

    American journal of epidemiology 162:10 2005 Nov 15 pg 975-82

    MeSH

    Adult
    Age Distribution
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Body Size
    Comorbidity
    Coronary Disease
    Diabetes Mellitus
    Dyslipidemias
    Exercise
    Humans
    Hypertension
    Incidence
    Longitudinal Studies
    Male
    Middle Aged
    Models, Statistical
    Prospective Studies
    Risk Factors
    Smoking
    Stroke
    Thromboembolism
    United States
    Venous Thrombosis

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16207808

    Citation

    Glynn, Robert J., and Bernard Rosner. "Comparison of Risk Factors for the Competing Risks of Coronary Heart Disease, Stroke, and Venous Thromboembolism." American Journal of Epidemiology, vol. 162, no. 10, 2005, pp. 975-82.
    Glynn RJ, Rosner B. Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. Am J Epidemiol. 2005;162(10):975-82.
    Glynn, R. J., & Rosner, B. (2005). Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. American Journal of Epidemiology, 162(10), pp. 975-82.
    Glynn RJ, Rosner B. Comparison of Risk Factors for the Competing Risks of Coronary Heart Disease, Stroke, and Venous Thromboembolism. Am J Epidemiol. 2005 Nov 15;162(10):975-82. PubMed PMID: 16207808.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. AU - Glynn,Robert J, AU - Rosner,Bernard, Y1 - 2005/10/05/ PY - 2005/10/7/pubmed PY - 2006/1/20/medline PY - 2005/10/7/entrez SP - 975 EP - 82 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 10 N2 - Methods for formal comparison of competing risks may clarify uncertainties about the associations of atherosclerotic risk factors with the development of venous thromboembolism (VTE). For a median of 20.1 years, the Physicians' Health Study (1982-2003) followed 18,662 US male physicians with no prior myocardial infarction, stroke, VTE, or cancer and for whom reported risk factor information was available at baseline. The authors used methods of competing risk survival analysis to compare relative hazard rates associated with age, hypertension, elevated cholesterol, diabetes, cigarette smoking, alcohol consumption, exercise frequency, body mass index, and height. During follow-up, coronary heart disease (CHD) occurred first in 1,348 men, stroke in 902 men, and VTE in 358 men. Incidence of all three outcomes increased with age, but the rate of increase was strongest for stroke. Hypertension, elevated cholesterol, diabetes, and smoking were associated with increased rates of CHD and stroke, with comparable magnitudes, but had no association with VTE. Conversely, higher body mass index was more strongly associated with risk of VTE than of either CHD or stroke, and taller men had a significantly increased risk of VTE but a lower risk of CHD. CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16207808/Comparison_of_risk_factors_for_the_competing_risks_of_coronary_heart_disease_stroke_and_venous_thromboembolism_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi309 DB - PRIME DP - Unbound Medicine ER -