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A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population.
Genes Immun. 2005 Oct; 6(7):632-5.GI

Abstract

Lactoferrin is an antimicrobial protein which plays an important role in regulating bacteria that are associated with aggressive periodontitis. Lactoferrin kills directly (via its strongly cationic N-terminal region) and indirectly, through sequestering the iron that bacteria require for growth. As aggressive periodontitis has a strong heritable component, we hypothesized that genetic variation within the lactoferrin gene may play a role in susceptibility to this condition. We have identified and examined a novel, functional, single-point A/G nucleotide mutation causing a threonine/alanine substitution at position 11 (T11A) of the secreted lactoferrin protein. In a pilot case-controlled study of aggressive periodontitis, analysis of 46 African-American patients and 78 controls showed that patients were twice as likely to express the G nucleotide (alanine) allele over controls (60.3 vs 30.4%; P=0.0007, odds ratio=2.564, 95% CI=1.475-4.459). A Caucasian population of 77 patients and 131 controls showed no such association (P=0.5201, odds ratio=0.862, 95% CI=0.548-1.356). The data presented provide a new insight into the genetic susceptibility to aggressive periodontitis.

Authors+Show Affiliations

Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16208406

Citation

Jordan, W J., et al. "A Non-conservative, Coding Single-nucleotide Polymorphism in the N-terminal Region of Lactoferrin Is Associated With Aggressive Periodontitis in an African-American, but Not a Caucasian Population." Genes and Immunity, vol. 6, no. 7, 2005, pp. 632-5.
Jordan WJ, Eskdale J, Lennon GP, et al. A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population. Genes Immun. 2005;6(7):632-5.
Jordan, W. J., Eskdale, J., Lennon, G. P., Pestoff, R., Wu, L., Fine, D. H., & Gallagher, G. (2005). A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population. Genes and Immunity, 6(7), 632-5.
Jordan WJ, et al. A Non-conservative, Coding Single-nucleotide Polymorphism in the N-terminal Region of Lactoferrin Is Associated With Aggressive Periodontitis in an African-American, but Not a Caucasian Population. Genes Immun. 2005;6(7):632-5. PubMed PMID: 16208406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population. AU - Jordan,W J, AU - Eskdale,J, AU - Lennon,G P, AU - Pestoff,R, AU - Wu,L, AU - Fine,D H, AU - Gallagher,G, PY - 2005/10/7/pubmed PY - 2005/12/16/medline PY - 2005/10/7/entrez SP - 632 EP - 5 JF - Genes and immunity JO - Genes Immun VL - 6 IS - 7 N2 - Lactoferrin is an antimicrobial protein which plays an important role in regulating bacteria that are associated with aggressive periodontitis. Lactoferrin kills directly (via its strongly cationic N-terminal region) and indirectly, through sequestering the iron that bacteria require for growth. As aggressive periodontitis has a strong heritable component, we hypothesized that genetic variation within the lactoferrin gene may play a role in susceptibility to this condition. We have identified and examined a novel, functional, single-point A/G nucleotide mutation causing a threonine/alanine substitution at position 11 (T11A) of the secreted lactoferrin protein. In a pilot case-controlled study of aggressive periodontitis, analysis of 46 African-American patients and 78 controls showed that patients were twice as likely to express the G nucleotide (alanine) allele over controls (60.3 vs 30.4%; P=0.0007, odds ratio=2.564, 95% CI=1.475-4.459). A Caucasian population of 77 patients and 131 controls showed no such association (P=0.5201, odds ratio=0.862, 95% CI=0.548-1.356). The data presented provide a new insight into the genetic susceptibility to aggressive periodontitis. SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/16208406/A_non_conservative_coding_single_nucleotide_polymorphism_in_the_N_terminal_region_of_lactoferrin_is_associated_with_aggressive_periodontitis_in_an_African_American_but_not_a_Caucasian_population_ L2 - https://doi.org/10.1038/sj.gene.6364239 DB - PRIME DP - Unbound Medicine ER -