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Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
J Allergy Clin Immunol. 2005 Oct; 116(4):805-11.JA

Abstract

BACKGROUND

Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization.

OBJECTIVE

The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups.

RESULTS

Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV.

CONCLUSION

Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils.

Authors+Show Affiliations

Children's Hospital Iceland, Reykjavik, Iceland. sig@landspitali.isNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16210054

Citation

Kristjansson, Sigurdur, et al. "Respiratory Syncytial Virus and Other Respiratory Viruses During the First 3 Months of Life Promote a Local TH2-like Response." The Journal of Allergy and Clinical Immunology, vol. 116, no. 4, 2005, pp. 805-11.
Kristjansson S, Bjarnarson SP, Wennergren G, et al. Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. J Allergy Clin Immunol. 2005;116(4):805-11.
Kristjansson, S., Bjarnarson, S. P., Wennergren, G., Palsdottir, A. H., Arnadottir, T., Haraldsson, A., & Jonsdottir, I. (2005). Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. The Journal of Allergy and Clinical Immunology, 116(4), 805-11.
Kristjansson S, et al. Respiratory Syncytial Virus and Other Respiratory Viruses During the First 3 Months of Life Promote a Local TH2-like Response. J Allergy Clin Immunol. 2005;116(4):805-11. PubMed PMID: 16210054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. AU - Kristjansson,Sigurdur, AU - Bjarnarson,Stefania P, AU - Wennergren,Göran, AU - Palsdottir,Aslaug H, AU - Arnadottir,Thorgerdur, AU - Haraldsson,Asgeir, AU - Jonsdottir,Ingileif, PY - 2005/05/25/received PY - 2005/07/13/revised PY - 2005/07/14/accepted PY - 2005/10/8/pubmed PY - 2005/12/13/medline PY - 2005/10/8/entrez SP - 805 EP - 11 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 116 IS - 4 N2 - BACKGROUND: Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization. OBJECTIVE: The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups. RESULTS: Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV. CONCLUSION: Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/16210054/Respiratory_syncytial_virus_and_other_respiratory_viruses_during_the_first_3_months_of_life_promote_a_local_TH2_like_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(05)01649-0 DB - PRIME DP - Unbound Medicine ER -