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Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease.
Mov Disord. 2006 Mar; 21(3):337-42.MD

Abstract

We describe the pattern of cognitive profiles within a community-based sample of patients with Parkinson's disease (PD) and dementia (PDD) using cluster analyses, and compare the results with data from patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Fifty patients with PDD and 39 with AD from Stavanger, Norway, and 62 patients with DLB from San Diego, CA, USA were diagnosed by either standardized clinical procedures or criteria (all PDD and all AD cases) or necropsy (all DLB cases). Four subgroups were identified: two subgroups with a subcortical cognitive profile (one with mild and one with moderate dementia severity), one subgroup with global impairment and severe dementia, and one subgroup with a cortical cognitive profile and moderate dementia. Of the patients with PDD and with DLB, 56% and 55%, respectively, had a subcortical cognitive profile, compared with only 33% of the AD patients. Conversely, 30% of the patients with PDD and 26% of those with DLB had a cortical cognitive profile, compared with 67% of the patients with AD. These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important.

Authors+Show Affiliations

Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway. caj@sir.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16211595

Citation

Janvin, Carmen Cristea, et al. "Cognitive Profiles of Individual Patients With Parkinson's Disease and Dementia: Comparison With Dementia With Lewy Bodies and Alzheimer's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 3, 2006, pp. 337-42.
Janvin CC, Larsen JP, Salmon DP, et al. Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease. Mov Disord. 2006;21(3):337-42.
Janvin, C. C., Larsen, J. P., Salmon, D. P., Galasko, D., Hugdahl, K., & Aarsland, D. (2006). Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 21(3), 337-42.
Janvin CC, et al. Cognitive Profiles of Individual Patients With Parkinson's Disease and Dementia: Comparison With Dementia With Lewy Bodies and Alzheimer's Disease. Mov Disord. 2006;21(3):337-42. PubMed PMID: 16211595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease. AU - Janvin,Carmen Cristea, AU - Larsen,Jan Petter, AU - Salmon,David P, AU - Galasko,Douglas, AU - Hugdahl,Kenneth, AU - Aarsland,Dag, PY - 2005/10/8/pubmed PY - 2006/8/4/medline PY - 2005/10/8/entrez SP - 337 EP - 42 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 3 N2 - We describe the pattern of cognitive profiles within a community-based sample of patients with Parkinson's disease (PD) and dementia (PDD) using cluster analyses, and compare the results with data from patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Fifty patients with PDD and 39 with AD from Stavanger, Norway, and 62 patients with DLB from San Diego, CA, USA were diagnosed by either standardized clinical procedures or criteria (all PDD and all AD cases) or necropsy (all DLB cases). Four subgroups were identified: two subgroups with a subcortical cognitive profile (one with mild and one with moderate dementia severity), one subgroup with global impairment and severe dementia, and one subgroup with a cortical cognitive profile and moderate dementia. Of the patients with PDD and with DLB, 56% and 55%, respectively, had a subcortical cognitive profile, compared with only 33% of the AD patients. Conversely, 30% of the patients with PDD and 26% of those with DLB had a cortical cognitive profile, compared with 67% of the patients with AD. These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16211595/Cognitive_profiles_of_individual_patients_with_Parkinson's_disease_and_dementia:_comparison_with_dementia_with_lewy_bodies_and_Alzheimer's_disease_ L2 - https://doi.org/10.1002/mds.20726 DB - PRIME DP - Unbound Medicine ER -