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Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice.
J Ethnopharmacol. 2006 Mar 08; 104(1-2):119-23.JE

Abstract

The anti-diabetic effect of Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) was studied. Cinnamon extract was administered at different dosages (50, 100, 150 and 200 mg/kg) for 6 weeks. It was found that blood glucose concentration is significantly decreased in a dose-dependent manner (P<0.001) with the most in the 200 mg/kg group compared with the control. In addition, serum insulin levels and HDL-cholesterol levels were significantly higher (P<0.01) and the concentration of triglyceride, total cholesterol and intestinal alpha-glycosidase activity were significantly lower after 6 weeks of the administration. These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine.

Authors+Show Affiliations

Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16213119

Citation

Kim, Sung Hee, et al. "Anti-diabetic Effect of Cinnamon Extract On Blood Glucose in Db/db Mice." Journal of Ethnopharmacology, vol. 104, no. 1-2, 2006, pp. 119-23.
Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol. 2006;104(1-2):119-23.
Kim, S. H., Hyun, S. H., & Choung, S. Y. (2006). Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of Ethnopharmacology, 104(1-2), 119-23.
Kim SH, Hyun SH, Choung SY. Anti-diabetic Effect of Cinnamon Extract On Blood Glucose in Db/db Mice. J Ethnopharmacol. 2006 Mar 8;104(1-2):119-23. PubMed PMID: 16213119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. AU - Kim,Sung Hee, AU - Hyun,Sun Hee, AU - Choung,Se Young, Y1 - 2005/10/05/ PY - 2004/12/16/received PY - 2005/08/05/revised PY - 2005/08/26/accepted PY - 2005/10/11/pubmed PY - 2006/7/29/medline PY - 2005/10/11/entrez SP - 119 EP - 23 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 104 IS - 1-2 N2 - The anti-diabetic effect of Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) was studied. Cinnamon extract was administered at different dosages (50, 100, 150 and 200 mg/kg) for 6 weeks. It was found that blood glucose concentration is significantly decreased in a dose-dependent manner (P<0.001) with the most in the 200 mg/kg group compared with the control. In addition, serum insulin levels and HDL-cholesterol levels were significantly higher (P<0.01) and the concentration of triglyceride, total cholesterol and intestinal alpha-glycosidase activity were significantly lower after 6 weeks of the administration. These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16213119/Anti_diabetic_effect_of_cinnamon_extract_on_blood_glucose_in_db/db_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00598-2 DB - PRIME DP - Unbound Medicine ER -