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Evaluation of the effectiveness of treatment with erythropoietin on anemia, cognitive functioning and functions studied by comprehensive geriatric assessment in elderly cancer patients with anemia related to cancer chemotherapy.
Crit Rev Oncol Hematol. 2006 Feb; 57(2):175-82.CR

Abstract

The primary aim of the present study was to examine the relationship of changes in hemoglobin levels following recombinant human erythropoietin (rHuEPO) treatment to changes in cognitive functioning studied by Mini Mental State Examination (MMSE) in elderly cancer patients undergoing chemotherapy treatment. The secondary aim was that to assess the relationship of changes in hemoglobin levels following rHuEPO treatment to changes in functions studied by Comprehensive Geriatic Assessment (CGA), such as Activity of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Geriatric Depression Scale (GDS) and the Mini Nutritional Assessment (MNA). To this end, hemoglobin levels and cognitive functioning were evaluated in a sample of cancer patients prior to the start of chemotherapy treatment and again after 4, 8 and 12 weeks of treatment with chemotherapy plus rHuEPO. Ten elderly patients (mean age 71.4 years) were enrolled. At baseline, enrolled patients had a mean Hb value of 10.3g/dl. After 4 weeks of rHuEPO treatment, Hb values increased significantly (p<0.0001), with a mean increase of 1.2g/dl (range: 0.2-2.1). Remarkably, 8 out of 10 (80%) showed an increase of Hb levels >or=1g/dl in comparison to baseline and therefore were considered responders. At baseline, four patients (40%) showed a moderate cognitive impairment, whilst six patients (60%) showed a normal cognitive function. After 4 weeks of rHuEPO treatment nine patients (90%) showed a significant improvement of cognitive functions in comparison to baseline (p<0.005): eight of them were responders also to rHuEPO in terms of correction of anemia. The Spearman's rank correlation test showed a statistical significant correlation between Hb increase and increase in cognitive functioning assessed by MMSE after 4 weeks (p=0.049), 8 weeks (p=0.044) and 12 weeks (p=0.031) of rHuEPO treatment. Therefore, the findings of this study provide support for the hypothesis that significant increases in hemoglobin over the course of chemotherapy supplemented with rHuEPO administration would be accompanied by significant improvement in cognitive performance over the same interval.

Authors+Show Affiliations

Department of Medical Oncology, University of Cagliari, Cagliari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16213740

Citation

Massa, Elena, et al. "Evaluation of the Effectiveness of Treatment With Erythropoietin On Anemia, Cognitive Functioning and Functions Studied By Comprehensive Geriatric Assessment in Elderly Cancer Patients With Anemia Related to Cancer Chemotherapy." Critical Reviews in Oncology/hematology, vol. 57, no. 2, 2006, pp. 175-82.
Massa E, Madeddu C, Lusso MR, et al. Evaluation of the effectiveness of treatment with erythropoietin on anemia, cognitive functioning and functions studied by comprehensive geriatric assessment in elderly cancer patients with anemia related to cancer chemotherapy. Crit Rev Oncol Hematol. 2006;57(2):175-82.
Massa, E., Madeddu, C., Lusso, M. R., Gramignano, G., & Mantovani, G. (2006). Evaluation of the effectiveness of treatment with erythropoietin on anemia, cognitive functioning and functions studied by comprehensive geriatric assessment in elderly cancer patients with anemia related to cancer chemotherapy. Critical Reviews in Oncology/hematology, 57(2), 175-82.
Massa E, et al. Evaluation of the Effectiveness of Treatment With Erythropoietin On Anemia, Cognitive Functioning and Functions Studied By Comprehensive Geriatric Assessment in Elderly Cancer Patients With Anemia Related to Cancer Chemotherapy. Crit Rev Oncol Hematol. 2006;57(2):175-82. PubMed PMID: 16213740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the effectiveness of treatment with erythropoietin on anemia, cognitive functioning and functions studied by comprehensive geriatric assessment in elderly cancer patients with anemia related to cancer chemotherapy. AU - Massa,Elena, AU - Madeddu,Clelia, AU - Lusso,Maria Rita, AU - Gramignano,Giulia, AU - Mantovani,Giovanni, Y1 - 2005/10/06/ PY - 2005/03/30/received PY - 2005/05/30/revised PY - 2005/06/03/accepted PY - 2005/10/11/pubmed PY - 2006/5/11/medline PY - 2005/10/11/entrez SP - 175 EP - 82 JF - Critical reviews in oncology/hematology JO - Crit. Rev. Oncol. Hematol. VL - 57 IS - 2 N2 - The primary aim of the present study was to examine the relationship of changes in hemoglobin levels following recombinant human erythropoietin (rHuEPO) treatment to changes in cognitive functioning studied by Mini Mental State Examination (MMSE) in elderly cancer patients undergoing chemotherapy treatment. The secondary aim was that to assess the relationship of changes in hemoglobin levels following rHuEPO treatment to changes in functions studied by Comprehensive Geriatic Assessment (CGA), such as Activity of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Geriatric Depression Scale (GDS) and the Mini Nutritional Assessment (MNA). To this end, hemoglobin levels and cognitive functioning were evaluated in a sample of cancer patients prior to the start of chemotherapy treatment and again after 4, 8 and 12 weeks of treatment with chemotherapy plus rHuEPO. Ten elderly patients (mean age 71.4 years) were enrolled. At baseline, enrolled patients had a mean Hb value of 10.3g/dl. After 4 weeks of rHuEPO treatment, Hb values increased significantly (p<0.0001), with a mean increase of 1.2g/dl (range: 0.2-2.1). Remarkably, 8 out of 10 (80%) showed an increase of Hb levels >or=1g/dl in comparison to baseline and therefore were considered responders. At baseline, four patients (40%) showed a moderate cognitive impairment, whilst six patients (60%) showed a normal cognitive function. After 4 weeks of rHuEPO treatment nine patients (90%) showed a significant improvement of cognitive functions in comparison to baseline (p<0.005): eight of them were responders also to rHuEPO in terms of correction of anemia. The Spearman's rank correlation test showed a statistical significant correlation between Hb increase and increase in cognitive functioning assessed by MMSE after 4 weeks (p=0.049), 8 weeks (p=0.044) and 12 weeks (p=0.031) of rHuEPO treatment. Therefore, the findings of this study provide support for the hypothesis that significant increases in hemoglobin over the course of chemotherapy supplemented with rHuEPO administration would be accompanied by significant improvement in cognitive performance over the same interval. SN - 1040-8428 UR - https://www.unboundmedicine.com/medline/citation/16213740/Evaluation_of_the_effectiveness_of_treatment_with_erythropoietin_on_anemia_cognitive_functioning_and_functions_studied_by_comprehensive_geriatric_assessment_in_elderly_cancer_patients_with_anemia_related_to_cancer_chemotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1040-8428(05)00123-X DB - PRIME DP - Unbound Medicine ER -