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Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study.
Neuroimage. 2006 Feb 01; 29(3):948-64.N

Abstract

Previous findings demonstrated that haplotype B of CST3, the gene coding for cystatin C, is a recessive risk factor for late-onset Alzheimer's disease (AD; Finckh, U., von der Kammer, H., Velden, J., Michel, T., Andresen, B., Deng, A., Zhang, J., Muller-Thomsen, T., Zuchowski, K., Menzer, G., Mann, U., Papassotiropoulos, A., Heun, R., Zurdel, J., Holst, F., Benussi, L., Stoppe, G., Reiss, J., Miserez, A.R., Staehelin, H.B., Rebeck, G.W., Hyman, B.T., Binetti, G., Hock, C., Growdon, J.H., Nitsch, R.M., 2000. Genetic association of the cystatin C gene with late-onset Alzheimer disease. Arch. Neurol. 57, 1579-1583). In the present multicentric electroencephalographic (EEG) study, we analyzed the effects of CST3 haplotypes on resting cortical rhythmicity in subjects with AD and mild cognitive impairment (MCI) with the hypothesis that sources of resting EEG rhythms are more impaired in carriers of the CST3 B haplotype than non-carriers. We enrolled a population of 84 MCI subjects (42% with the B haplotype) and 65 AD patients (40% with the B haplotype). Resting eyes-closed EEG data were recorded in all subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Results showed that the amplitude of alpha 1 (parietal, occipital, temporal areas) and alpha 2 (occipital area) was statistically lower in CST3 B carriers than non-carriers (P < 0.01). Whereas there was a trend towards statistical significance that amplitude of occipital delta sources was stronger in CST3 B carriers than in non-carriers. This was true for both MCI and AD subjects. The present findings represent the first demonstration of relationships between the AD genetic risk factor CST3 B and global neurophysiological phenotype (i.e., cortical delta and alpha rhythmicity) in MCI and AD subjects, prompting future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

Authors+Show Affiliations

Dip. Fisiologia Umana e Farmacologia, Univ. La Sapienza Rome, Italy. claudio.babiloni@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16213753

Citation

Babiloni, Claudio, et al. "Genotype (cystatin C) and EEG Phenotype in Alzheimer Disease and Mild Cognitive Impairment: a Multicentric Study." NeuroImage, vol. 29, no. 3, 2006, pp. 948-64.
Babiloni C, Benussi L, Binetti G, et al. Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study. Neuroimage. 2006;29(3):948-64.
Babiloni, C., Benussi, L., Binetti, G., Bosco, P., Busonero, G., Cesaretti, S., Dal Forno, G., Del Percio, C., Ferri, R., Frisoni, G., Ghidoni, R., Rodriguez, G., Squitti, R., & Rossini, P. M. (2006). Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study. NeuroImage, 29(3), 948-64.
Babiloni C, et al. Genotype (cystatin C) and EEG Phenotype in Alzheimer Disease and Mild Cognitive Impairment: a Multicentric Study. Neuroimage. 2006 Feb 1;29(3):948-64. PubMed PMID: 16213753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study. AU - Babiloni,Claudio, AU - Benussi,Luisa, AU - Binetti,Giuliano, AU - Bosco,Paolo, AU - Busonero,Gabriella, AU - Cesaretti,Simona, AU - Dal Forno,Gloria, AU - Del Percio,Claudio, AU - Ferri,Raffaele, AU - Frisoni,Giovanni, AU - Ghidoni,Roberta, AU - Rodriguez,Guido, AU - Squitti,Rosanna, AU - Rossini,Paolo M, Y1 - 2005/10/06/ PY - 2005/05/06/received PY - 2005/07/22/revised PY - 2005/08/25/accepted PY - 2005/10/11/pubmed PY - 2006/3/30/medline PY - 2005/10/11/entrez SP - 948 EP - 64 JF - NeuroImage JO - Neuroimage VL - 29 IS - 3 N2 - Previous findings demonstrated that haplotype B of CST3, the gene coding for cystatin C, is a recessive risk factor for late-onset Alzheimer's disease (AD; Finckh, U., von der Kammer, H., Velden, J., Michel, T., Andresen, B., Deng, A., Zhang, J., Muller-Thomsen, T., Zuchowski, K., Menzer, G., Mann, U., Papassotiropoulos, A., Heun, R., Zurdel, J., Holst, F., Benussi, L., Stoppe, G., Reiss, J., Miserez, A.R., Staehelin, H.B., Rebeck, G.W., Hyman, B.T., Binetti, G., Hock, C., Growdon, J.H., Nitsch, R.M., 2000. Genetic association of the cystatin C gene with late-onset Alzheimer disease. Arch. Neurol. 57, 1579-1583). In the present multicentric electroencephalographic (EEG) study, we analyzed the effects of CST3 haplotypes on resting cortical rhythmicity in subjects with AD and mild cognitive impairment (MCI) with the hypothesis that sources of resting EEG rhythms are more impaired in carriers of the CST3 B haplotype than non-carriers. We enrolled a population of 84 MCI subjects (42% with the B haplotype) and 65 AD patients (40% with the B haplotype). Resting eyes-closed EEG data were recorded in all subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Results showed that the amplitude of alpha 1 (parietal, occipital, temporal areas) and alpha 2 (occipital area) was statistically lower in CST3 B carriers than non-carriers (P < 0.01). Whereas there was a trend towards statistical significance that amplitude of occipital delta sources was stronger in CST3 B carriers than in non-carriers. This was true for both MCI and AD subjects. The present findings represent the first demonstration of relationships between the AD genetic risk factor CST3 B and global neurophysiological phenotype (i.e., cortical delta and alpha rhythmicity) in MCI and AD subjects, prompting future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/16213753/Genotype__cystatin_C__and_EEG_phenotype_in_Alzheimer_disease_and_mild_cognitive_impairment:_a_multicentric_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(05)00632-4 DB - PRIME DP - Unbound Medicine ER -