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Immunofluorescence studies of atrophie blanche with antibodies against fibrinogen, fibrin, plasminogen activator inhibitor, factor VIII-related antigen, and collagen type IV.
Vasa. 1992; 21(2):143-8.VASA

Abstract

In and around ulcers complicating the chronic venous insufficiency syndrome and atrophie blanche a pericapillary cuff of fibrinoid material has been described. The aim of the present study was to find out whether pericapillary cuffs are present in atrophie blanche ulcerations, whether they consist of fibrinogen and/or fibrin in comparison to normal controls, and whether this cuff is composed of other components. Skin biopsies from ten patients adjacent to atrophie blanche ulcers, and from ten controls were taken. In all patients pericapillary cuffs consisting of fibrin were found. However, no fibrinogen was found in these cuffs. In the controls no cuffs were found. In this fibrin network factor VIII-related antigen and collagen type IV were also present. The finding of plasminogen activator inhibitor-I in the pericapillary cuff in several cases may indicate that breakdown of this fibrin cuff is impaired. The possible diffusion barrier caused by the pericapillary cuff together with the pattern of vascularization may be an important event in ulcer formation and impaired ulcer healing.

Authors+Show Affiliations

Department of Dermatology, Hospital De Lichtenberg, Amersfoort, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1621431

Citation

Brakman, M, et al. "Immunofluorescence Studies of Atrophie Blanche With Antibodies Against Fibrinogen, Fibrin, Plasminogen Activator Inhibitor, Factor VIII-related Antigen, and Collagen Type IV." VASA. Zeitschrift Fur Gefasskrankheiten, vol. 21, no. 2, 1992, pp. 143-8.
Brakman M, Faber WR, Kerckhaert JA, et al. Immunofluorescence studies of atrophie blanche with antibodies against fibrinogen, fibrin, plasminogen activator inhibitor, factor VIII-related antigen, and collagen type IV. Vasa. 1992;21(2):143-8.
Brakman, M., Faber, W. R., Kerckhaert, J. A., Kraaijenhagen, R. J., & Hart, H. C. (1992). Immunofluorescence studies of atrophie blanche with antibodies against fibrinogen, fibrin, plasminogen activator inhibitor, factor VIII-related antigen, and collagen type IV. VASA. Zeitschrift Fur Gefasskrankheiten, 21(2), 143-8.
Brakman M, et al. Immunofluorescence Studies of Atrophie Blanche With Antibodies Against Fibrinogen, Fibrin, Plasminogen Activator Inhibitor, Factor VIII-related Antigen, and Collagen Type IV. Vasa. 1992;21(2):143-8. PubMed PMID: 1621431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunofluorescence studies of atrophie blanche with antibodies against fibrinogen, fibrin, plasminogen activator inhibitor, factor VIII-related antigen, and collagen type IV. AU - Brakman,M, AU - Faber,W R, AU - Kerckhaert,J A, AU - Kraaijenhagen,R J, AU - Hart,H C, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 143 EP - 8 JF - VASA. Zeitschrift fur Gefasskrankheiten JO - Vasa VL - 21 IS - 2 N2 - In and around ulcers complicating the chronic venous insufficiency syndrome and atrophie blanche a pericapillary cuff of fibrinoid material has been described. The aim of the present study was to find out whether pericapillary cuffs are present in atrophie blanche ulcerations, whether they consist of fibrinogen and/or fibrin in comparison to normal controls, and whether this cuff is composed of other components. Skin biopsies from ten patients adjacent to atrophie blanche ulcers, and from ten controls were taken. In all patients pericapillary cuffs consisting of fibrin were found. However, no fibrinogen was found in these cuffs. In the controls no cuffs were found. In this fibrin network factor VIII-related antigen and collagen type IV were also present. The finding of plasminogen activator inhibitor-I in the pericapillary cuff in several cases may indicate that breakdown of this fibrin cuff is impaired. The possible diffusion barrier caused by the pericapillary cuff together with the pattern of vascularization may be an important event in ulcer formation and impaired ulcer healing. SN - 0301-1526 UR - https://www.unboundmedicine.com/medline/citation/1621431/Immunofluorescence_studies_of_atrophie_blanche_with_antibodies_against_fibrinogen_fibrin_plasminogen_activator_inhibitor_factor_VIII_related_antigen_and_collagen_type_IV_ DB - PRIME DP - Unbound Medicine ER -