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Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review.
J Nutr Biochem. 2006 Jan; 17(1):1-13.JN

Abstract

For many years, clinical and animal studies on polyunsaturated n-3 fatty acids (PUFAs), especially those from marine oil, eicosapentaenoic acid (20:5,n-3) and docosahexaenoic acid (22:6,n-3), have reported the impact of their beneficial effects on both health and diseases. Among other things, they regulate lipid levels, cardiovascular and immune functions as well as insulin action. Polyunsaturated fatty acids are vital components of the phospholipids of membrane cells and serve as important mediators of the nuclear events governing the specific gene expression involved in lipid and glucose metabolism and adipogenesis. Besides, dietary n-3 PUFAs seem to play an important protecting role against the adverse symptoms of the Plurimetabolic syndrome. This review highlights some recent advances in the understanding of metabolic and molecular mechanisms concerning the effect of dietary PUFAs (fish oil) and focuses on the prevention and/or improvement of dyslipidemia, insulin resistance, impaired glucose homeostasis, diabetes and obesity in experimental animal models, with some extension to humans.

Authors+Show Affiliations

Department of Biochemistry, School of Biochemistry, University of Litoral, Santa Fe 3000, Argentina. ylombard@fbcb.unl.edu.arNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16214332

Citation

Lombardo, Yolanda B., and Adriana G. Chicco. "Effects of Dietary Polyunsaturated N-3 Fatty Acids On Dyslipidemia and Insulin Resistance in Rodents and Humans. a Review." The Journal of Nutritional Biochemistry, vol. 17, no. 1, 2006, pp. 1-13.
Lombardo YB, Chicco AG. Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review. J Nutr Biochem. 2006;17(1):1-13.
Lombardo, Y. B., & Chicco, A. G. (2006). Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review. The Journal of Nutritional Biochemistry, 17(1), 1-13.
Lombardo YB, Chicco AG. Effects of Dietary Polyunsaturated N-3 Fatty Acids On Dyslipidemia and Insulin Resistance in Rodents and Humans. a Review. J Nutr Biochem. 2006;17(1):1-13. PubMed PMID: 16214332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review. AU - Lombardo,Yolanda B, AU - Chicco,Adriana G, Y1 - 2005/09/08/ PY - 2005/10/11/pubmed PY - 2006/3/10/medline PY - 2005/10/11/entrez SP - 1 EP - 13 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 17 IS - 1 N2 - For many years, clinical and animal studies on polyunsaturated n-3 fatty acids (PUFAs), especially those from marine oil, eicosapentaenoic acid (20:5,n-3) and docosahexaenoic acid (22:6,n-3), have reported the impact of their beneficial effects on both health and diseases. Among other things, they regulate lipid levels, cardiovascular and immune functions as well as insulin action. Polyunsaturated fatty acids are vital components of the phospholipids of membrane cells and serve as important mediators of the nuclear events governing the specific gene expression involved in lipid and glucose metabolism and adipogenesis. Besides, dietary n-3 PUFAs seem to play an important protecting role against the adverse symptoms of the Plurimetabolic syndrome. This review highlights some recent advances in the understanding of metabolic and molecular mechanisms concerning the effect of dietary PUFAs (fish oil) and focuses on the prevention and/or improvement of dyslipidemia, insulin resistance, impaired glucose homeostasis, diabetes and obesity in experimental animal models, with some extension to humans. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/16214332/Effects_of_dietary_polyunsaturated_n_3_fatty_acids_on_dyslipidemia_and_insulin_resistance_in_rodents_and_humans__A_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(05)00211-1 DB - PRIME DP - Unbound Medicine ER -