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Dietary magnesium intake and risk of cardiovascular disease among women.

Abstract

This study assessed the hypothesis that greater magnesium intake is associated with reduced risk for cardiovascular disease (CVD), including myocardial infarction (MI) and stroke, in a large prospective cohort of women. In 1993, a semi-quantitative food frequency questionnaire was used to assess magnesium intake in 39,876 female health professionals aged 39 to 89 years who had no history of CVD or cancer. During a median of 10 years of follow-up, 1,037 incident cases of CVD were identified, including 280 nonfatal MIs and 368 strokes. After adjustment for age and randomized treatment status, magnesium intake was not significantly associated with risk for incident CVD. Comparing the highest quintile of magnesium intake (median 433 mg/day) with the lowest quintile (median 255 mg/day), the relative risks were 0.87 (95% confidence interval [CI] 0.72 to 1.05, p for trend = 0.24) for total CVD, 0.88 (95% CI 0.70 to 1.12, p for trend = 0.34) for coronary heart disease (CHD), 1.03 (95% CI 0.72 to 1.49, p for trend = 0.96) for nonfatal MI, 1.11 (95% CI 0.61 to 2.00, p for trend = 0.95) for CVD death, and 0.87 (95% CI 0.64 to 1.18, p for trend = 0.55) for total stroke. Additional adjustment for other CVD risk factors did not materially change the observed null associations. In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ysong@hsph.harvard.edu

    , , , ,

    Source

    The American journal of cardiology 96:8 2005 Oct 15 pg 1135-41

    MeSH

    Adult
    Aged
    Cardiovascular Diseases
    Confidence Intervals
    Diet
    Double-Blind Method
    Female
    Humans
    Magnesium
    Middle Aged
    Myocardial Infarction
    Risk Factors
    Stroke
    Women's Health

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    16214452

    Citation

    Song, Yiqing, et al. "Dietary Magnesium Intake and Risk of Cardiovascular Disease Among Women." The American Journal of Cardiology, vol. 96, no. 8, 2005, pp. 1135-41.
    Song Y, Manson JE, Cook NR, et al. Dietary magnesium intake and risk of cardiovascular disease among women. Am J Cardiol. 2005;96(8):1135-41.
    Song, Y., Manson, J. E., Cook, N. R., Albert, C. M., Buring, J. E., & Liu, S. (2005). Dietary magnesium intake and risk of cardiovascular disease among women. The American Journal of Cardiology, 96(8), pp. 1135-41.
    Song Y, et al. Dietary Magnesium Intake and Risk of Cardiovascular Disease Among Women. Am J Cardiol. 2005 Oct 15;96(8):1135-41. PubMed PMID: 16214452.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary magnesium intake and risk of cardiovascular disease among women. AU - Song,Yiqing, AU - Manson,JoAnn E, AU - Cook,Nancy R, AU - Albert,Christine M, AU - Buring,Julie E, AU - Liu,Simin, Y1 - 2005/08/29/ PY - 2005/04/04/received PY - 2005/06/13/revised PY - 2005/06/13/accepted PY - 2005/10/11/pubmed PY - 2005/12/13/medline PY - 2005/10/11/entrez SP - 1135 EP - 41 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 96 IS - 8 N2 - This study assessed the hypothesis that greater magnesium intake is associated with reduced risk for cardiovascular disease (CVD), including myocardial infarction (MI) and stroke, in a large prospective cohort of women. In 1993, a semi-quantitative food frequency questionnaire was used to assess magnesium intake in 39,876 female health professionals aged 39 to 89 years who had no history of CVD or cancer. During a median of 10 years of follow-up, 1,037 incident cases of CVD were identified, including 280 nonfatal MIs and 368 strokes. After adjustment for age and randomized treatment status, magnesium intake was not significantly associated with risk for incident CVD. Comparing the highest quintile of magnesium intake (median 433 mg/day) with the lowest quintile (median 255 mg/day), the relative risks were 0.87 (95% confidence interval [CI] 0.72 to 1.05, p for trend = 0.24) for total CVD, 0.88 (95% CI 0.70 to 1.12, p for trend = 0.34) for coronary heart disease (CHD), 1.03 (95% CI 0.72 to 1.49, p for trend = 0.96) for nonfatal MI, 1.11 (95% CI 0.61 to 2.00, p for trend = 0.95) for CVD death, and 0.87 (95% CI 0.64 to 1.18, p for trend = 0.55) for total stroke. Additional adjustment for other CVD risk factors did not materially change the observed null associations. In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16214452/Dietary_magnesium_intake_and_risk_of_cardiovascular_disease_among_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)01176-8 DB - PRIME DP - Unbound Medicine ER -