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The environment and risk factors for atopy.
Curr Allergy Asthma Rep 2005; 5(6):445-50CA

Abstract

Atopy is the genetic potential to manifest the trinity of classic allergic diseases--atopic dermatitis, allergic rhinitis, and asthma. All have been observed to have increased over the past several decades. The interplay of the genetics of atopy with various environmental exposures may manifest itself in the form of allergic phenotypes or paradoxically may actually suppress the allergic response. The hygiene hypothesis offers an explanation of why certain environmental exposures early in life may suppress or activate clinical disease. Primary prevention is directed at preventing the clinical manifestations of atopy by suppressing or delaying the onset of allergic sensitivity. Studies of primary prevention have brought mixed results. Secondary prevention is directed at reducing or removing triggers in the environment of the sensitized individual. Secondary prevention measures directed at one allergen have not proven successful. Comprehensive intervention programs dealing with both allergens and other potential triggers appear beneficial.

Authors+Show Affiliations

Family Allergy & Asthma, 9800 Shelbyville Road, Suite 220, Louisville, KY 40223, USA. jsublett@familyallergy.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16216168

Citation

Sublett, James L.. "The Environment and Risk Factors for Atopy." Current Allergy and Asthma Reports, vol. 5, no. 6, 2005, pp. 445-50.
Sublett JL. The environment and risk factors for atopy. Curr Allergy Asthma Rep. 2005;5(6):445-50.
Sublett, J. L. (2005). The environment and risk factors for atopy. Current Allergy and Asthma Reports, 5(6), pp. 445-50.
Sublett JL. The Environment and Risk Factors for Atopy. Curr Allergy Asthma Rep. 2005;5(6):445-50. PubMed PMID: 16216168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The environment and risk factors for atopy. A1 - Sublett,James L, PY - 2005/10/12/pubmed PY - 2006/1/26/medline PY - 2005/10/12/entrez SP - 445 EP - 50 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 5 IS - 6 N2 - Atopy is the genetic potential to manifest the trinity of classic allergic diseases--atopic dermatitis, allergic rhinitis, and asthma. All have been observed to have increased over the past several decades. The interplay of the genetics of atopy with various environmental exposures may manifest itself in the form of allergic phenotypes or paradoxically may actually suppress the allergic response. The hygiene hypothesis offers an explanation of why certain environmental exposures early in life may suppress or activate clinical disease. Primary prevention is directed at preventing the clinical manifestations of atopy by suppressing or delaying the onset of allergic sensitivity. Studies of primary prevention have brought mixed results. Secondary prevention is directed at reducing or removing triggers in the environment of the sensitized individual. Secondary prevention measures directed at one allergen have not proven successful. Comprehensive intervention programs dealing with both allergens and other potential triggers appear beneficial. SN - 1529-7322 UR - https://www.unboundmedicine.com/medline/citation/16216168/The_environment_and_risk_factors_for_atopy_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -