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Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease.
Ann Epidemiol. 2006 Feb; 16(2):105-12.AE

Abstract

PURPOSE

C-reactive protein (CRP), androgens, and menopausal loss of endogenous estrogens are associated with cardiovascular disease (CVD). We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women.

METHODS

CRP, SHBG, estradiol, and total testosterone were measured using baseline bloods of 221 hormone therapy (HT)-nonusers and 162 HT-users from a cross-sectional analysis in a nested case-control sample of the Women's Health Study. Hormones and CRP were ln-transformed and relationships were assessed with Spearman correlations and linear regression.

RESULTS

ln-SHBG (beta=-0.40; p<0.01) and ln-testosterone (beta=-0.24; p=0.04) were the only independent hormonal predictors of ln-CRP among HT-nonusers after adjusting for age, hypertension, smoking, body mass index, diabetes, exercise, HDL cholesterol, alcohol intake, and CVD occurrence during follow-up. Upon stratification, the association between ln-SHBG and ln-CRP persisted among HT nonusers who subsequently developed CVD (beta=-0.55; p=0.01), but not among women who remained CVD-free (p=0.28). The inverse relationship between ln-SHBG and ln-CRP was strongest among the leanest women. None of the sex-hormones predicted ln-CRP among HT-users.

CONCLUSIONS

SHBG and total testosterone were inversely associated with CRP among HT nonusers in this study. The relationship between SHBG and CRP was more strongly inverse among leaner women.

Authors+Show Affiliations

Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02215, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16216530

Citation

Joffe, Hylton V., et al. "Sex Hormone-binding Globulin and Serum Testosterone Are Inversely Associated With C-reactive Protein Levels in Postmenopausal Women at High Risk for Cardiovascular Disease." Annals of Epidemiology, vol. 16, no. 2, 2006, pp. 105-12.
Joffe HV, Ridker PM, Manson JE, et al. Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Ann Epidemiol. 2006;16(2):105-12.
Joffe, H. V., Ridker, P. M., Manson, J. E., Cook, N. R., Buring, J. E., & Rexrode, K. M. (2006). Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Annals of Epidemiology, 16(2), 105-12.
Joffe HV, et al. Sex Hormone-binding Globulin and Serum Testosterone Are Inversely Associated With C-reactive Protein Levels in Postmenopausal Women at High Risk for Cardiovascular Disease. Ann Epidemiol. 2006;16(2):105-12. PubMed PMID: 16216530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. AU - Joffe,Hylton V, AU - Ridker,Paul M, AU - Manson,Joann E, AU - Cook,Nancy R, AU - Buring,Julie E, AU - Rexrode,Kathryn M, Y1 - 2005/10/10/ PY - 2005/04/22/received PY - 2005/07/18/revised PY - 2005/07/19/accepted PY - 2005/10/12/pubmed PY - 2007/7/4/medline PY - 2005/10/12/entrez SP - 105 EP - 12 JF - Annals of epidemiology JO - Ann Epidemiol VL - 16 IS - 2 N2 - PURPOSE: C-reactive protein (CRP), androgens, and menopausal loss of endogenous estrogens are associated with cardiovascular disease (CVD). We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women. METHODS: CRP, SHBG, estradiol, and total testosterone were measured using baseline bloods of 221 hormone therapy (HT)-nonusers and 162 HT-users from a cross-sectional analysis in a nested case-control sample of the Women's Health Study. Hormones and CRP were ln-transformed and relationships were assessed with Spearman correlations and linear regression. RESULTS: ln-SHBG (beta=-0.40; p<0.01) and ln-testosterone (beta=-0.24; p=0.04) were the only independent hormonal predictors of ln-CRP among HT-nonusers after adjusting for age, hypertension, smoking, body mass index, diabetes, exercise, HDL cholesterol, alcohol intake, and CVD occurrence during follow-up. Upon stratification, the association between ln-SHBG and ln-CRP persisted among HT nonusers who subsequently developed CVD (beta=-0.55; p=0.01), but not among women who remained CVD-free (p=0.28). The inverse relationship between ln-SHBG and ln-CRP was strongest among the leanest women. None of the sex-hormones predicted ln-CRP among HT-users. CONCLUSIONS: SHBG and total testosterone were inversely associated with CRP among HT nonusers in this study. The relationship between SHBG and CRP was more strongly inverse among leaner women. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/16216530/Sex_hormone_binding_globulin_and_serum_testosterone_are_inversely_associated_with_C_reactive_protein_levels_in_postmenopausal_women_at_high_risk_for_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(05)00267-X DB - PRIME DP - Unbound Medicine ER -