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Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task.
Brain Res Bull. 2005 Nov 30; 67(6):504-8.BR

Abstract

It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. In this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combination to male Wistar rats before training on the inhibitory avoidance task. MK-801 and DIC in sub-effective doses were administered in combination. It was observed that MK-801 at a dose of 0.1125 mg/kg with a sub-effective dose of 8 mg/kg of DIC significantly impaired the retention test when compared with saline-treated animals, i.e. MK-801 potentiated the effects of dicyclomine on memory impairment. Our results suggest an important role for the M1-muscarinic receptor in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors, which is in line with the findings that the interactive modulation between these two neurotransmitters systems constitutes an important mechanism in cognitive functions.

Authors+Show Affiliations

Universidade Federal de São Paulo, Departamento de Psicobiologia, Rua Napoleão de Barros 925, CEP 04024-002, São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16216700

Citation

Monteiro Moreira, Karin, et al. "Interaction Between M1-muscarinic and Glutamatergic NMDA Receptors On an Inhibitory Avoidance Task." Brain Research Bulletin, vol. 67, no. 6, 2005, pp. 504-8.
Monteiro Moreira K, Lima Ferreira T, Vecchio Fornari R, et al. Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task. Brain Res Bull. 2005;67(6):504-8.
Monteiro Moreira, K., Lima Ferreira, T., Vecchio Fornari, R., Perez Figueredo, L. Z., & Menezes Oliveira, M. G. (2005). Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task. Brain Research Bulletin, 67(6), 504-8.
Monteiro Moreira K, et al. Interaction Between M1-muscarinic and Glutamatergic NMDA Receptors On an Inhibitory Avoidance Task. Brain Res Bull. 2005 Nov 30;67(6):504-8. PubMed PMID: 16216700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task. AU - Monteiro Moreira,Karin, AU - Lima Ferreira,Tatiana, AU - Vecchio Fornari,Raquel, AU - Perez Figueredo,Larissa Zeggio, AU - Menezes Oliveira,Maria Gabriela, Y1 - 2005/09/07/ PY - 2004/11/22/received PY - 2005/06/28/revised PY - 2005/07/28/accepted PY - 2005/10/12/pubmed PY - 2005/12/21/medline PY - 2005/10/12/entrez SP - 504 EP - 8 JF - Brain research bulletin JO - Brain Res Bull VL - 67 IS - 6 N2 - It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. In this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combination to male Wistar rats before training on the inhibitory avoidance task. MK-801 and DIC in sub-effective doses were administered in combination. It was observed that MK-801 at a dose of 0.1125 mg/kg with a sub-effective dose of 8 mg/kg of DIC significantly impaired the retention test when compared with saline-treated animals, i.e. MK-801 potentiated the effects of dicyclomine on memory impairment. Our results suggest an important role for the M1-muscarinic receptor in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors, which is in line with the findings that the interactive modulation between these two neurotransmitters systems constitutes an important mechanism in cognitive functions. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/16216700/Interaction_between_M1_muscarinic_and_glutamatergic_NMDA_receptors_on_an_inhibitory_avoidance_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(05)00303-5 DB - PRIME DP - Unbound Medicine ER -