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Isocaloric substitution of plant sterol-enriched fat spread for carbohydrate-rich foods in a low-fat, fibre-rich diet decreases plasma low-density lipoprotein cholesterol and increases high-density lipoprotein concentrations.
Nutr Metab Cardiovasc Dis 2005; 15(5):337-44NM

Abstract

BACKGROUND AND AIM

The aim of the study was to determine the effects on plasma cholesterol of replacing a plant sterol-enriched fat spread with carbohydrate-rich foods relative to a diet high in saturated fat.

METHODS AND RESULTS

Twenty-nine men and women, from the general community, with mean age (SD) 48 (14)y, body mass index 29.0 (6.2)kg/m(2), and plasma total cholesterol concentration 6.48 (0.97)mmol/L completed the randomised, crossover dietary intervention. There were three diets: New Zealand diet (NZ diet) high in total (34%kJ) and saturated (15%kJ) fat, a cholesterol-lowering fibre-rich diet reduced in total (30%kJ) and saturated fat (8%kJ) but including a plant sterol spread (PS diet), and the same cholesterol-lowering diet with the plant sterol spread isocalorically replaced with carbohydrate (CHO diet); total fat, 26%kJ; saturated fat 7%kJ. All foods were provided and each diet was followed for four weeks. Mean (SD) plasma low-density lipoprotein cholesterol concentration declined from 4.68 (0.91)mmol/L on the high saturated fat diet to 4.12 (0.83)mmol/L (P<0.001) on the carbohydrate diet and 3.76 (0.84)mmol/L (P<0.001) on the plant sterol diet. The 20% decrease on the plant sterol diet was significantly greater (P<0.001) than the 12% decrease on the carbohydrate diet. Relative to the NZ diet, mean (95% CI) plasma high-density lipoprotein cholesterol concentration changed by -0.11 (-0.16, -0.06)mmol/L on the CHO diet but was not different at the end of the PS diet, -0.03 (-0.09, 0.02).

CONCLUSION

Including a plant sterol-enriched fat spread in a cholesterol-lowering diet produces a more favourable plasma lipid profile than the same diet made lower in total and saturated fat by replacing the spread with carbohydrate-rich foods.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand. murray.skeaff@stonebow.otago.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16216719

Citation

Skeaff, C Murray, et al. "Isocaloric Substitution of Plant Sterol-enriched Fat Spread for Carbohydrate-rich Foods in a Low-fat, Fibre-rich Diet Decreases Plasma Low-density Lipoprotein Cholesterol and Increases High-density Lipoprotein Concentrations." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 15, no. 5, 2005, pp. 337-44.
Skeaff CM, Thoma C, Mann J, et al. Isocaloric substitution of plant sterol-enriched fat spread for carbohydrate-rich foods in a low-fat, fibre-rich diet decreases plasma low-density lipoprotein cholesterol and increases high-density lipoprotein concentrations. Nutr Metab Cardiovasc Dis. 2005;15(5):337-44.
Skeaff, C. M., Thoma, C., Mann, J., Chisholm, A., Williams, S., & Richmond, K. (2005). Isocaloric substitution of plant sterol-enriched fat spread for carbohydrate-rich foods in a low-fat, fibre-rich diet decreases plasma low-density lipoprotein cholesterol and increases high-density lipoprotein concentrations. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 15(5), pp. 337-44.
Skeaff CM, et al. Isocaloric Substitution of Plant Sterol-enriched Fat Spread for Carbohydrate-rich Foods in a Low-fat, Fibre-rich Diet Decreases Plasma Low-density Lipoprotein Cholesterol and Increases High-density Lipoprotein Concentrations. Nutr Metab Cardiovasc Dis. 2005;15(5):337-44. PubMed PMID: 16216719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isocaloric substitution of plant sterol-enriched fat spread for carbohydrate-rich foods in a low-fat, fibre-rich diet decreases plasma low-density lipoprotein cholesterol and increases high-density lipoprotein concentrations. AU - Skeaff,C Murray, AU - Thoma,Christian, AU - Mann,Jim, AU - Chisholm,Alex, AU - Williams,Sheila, AU - Richmond,Korina, Y1 - 2005/07/28/ PY - 2004/09/07/received PY - 2005/03/03/revised PY - 2005/03/03/accepted PY - 2005/10/12/pubmed PY - 2006/1/25/medline PY - 2005/10/12/entrez SP - 337 EP - 44 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 15 IS - 5 N2 - BACKGROUND AND AIM: The aim of the study was to determine the effects on plasma cholesterol of replacing a plant sterol-enriched fat spread with carbohydrate-rich foods relative to a diet high in saturated fat. METHODS AND RESULTS: Twenty-nine men and women, from the general community, with mean age (SD) 48 (14)y, body mass index 29.0 (6.2)kg/m(2), and plasma total cholesterol concentration 6.48 (0.97)mmol/L completed the randomised, crossover dietary intervention. There were three diets: New Zealand diet (NZ diet) high in total (34%kJ) and saturated (15%kJ) fat, a cholesterol-lowering fibre-rich diet reduced in total (30%kJ) and saturated fat (8%kJ) but including a plant sterol spread (PS diet), and the same cholesterol-lowering diet with the plant sterol spread isocalorically replaced with carbohydrate (CHO diet); total fat, 26%kJ; saturated fat 7%kJ. All foods were provided and each diet was followed for four weeks. Mean (SD) plasma low-density lipoprotein cholesterol concentration declined from 4.68 (0.91)mmol/L on the high saturated fat diet to 4.12 (0.83)mmol/L (P<0.001) on the carbohydrate diet and 3.76 (0.84)mmol/L (P<0.001) on the plant sterol diet. The 20% decrease on the plant sterol diet was significantly greater (P<0.001) than the 12% decrease on the carbohydrate diet. Relative to the NZ diet, mean (95% CI) plasma high-density lipoprotein cholesterol concentration changed by -0.11 (-0.16, -0.06)mmol/L on the CHO diet but was not different at the end of the PS diet, -0.03 (-0.09, 0.02). CONCLUSION: Including a plant sterol-enriched fat spread in a cholesterol-lowering diet produces a more favourable plasma lipid profile than the same diet made lower in total and saturated fat by replacing the spread with carbohydrate-rich foods. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/16216719/Isocaloric_substitution_of_plant_sterol_enriched_fat_spread_for_carbohydrate_rich_foods_in_a_low_fat_fibre_rich_diet_decreases_plasma_low_density_lipoprotein_cholesterol_and_increases_high_density_lipoprotein_concentrations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(05)00075-X DB - PRIME DP - Unbound Medicine ER -