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Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve.
J Exp Med. 2005 Oct 17; 202(8):1023-9.JE

Abstract

The immune system in vertebrates senses exogenous and endogenous danger signals by way of complex cellular and humoral processes, and responds with an inflammatory reaction to combat putative attacks. A strong protective immunity is imperative to prevent invasion of pathogens; however, equivalent responses to commensal flora and dietary components in the intestine have to be avoided. The autonomic nervous system plays an important role in sensing luminal contents in the gut by way of hard-wired connections and chemical messengers, such as cholecystokinin (CCK). Here, we report that ingestion of dietary fat stimulates CCK receptors, and leads to attenuation of the inflammatory response by way of the efferent vagus nerve and nicotinic receptors. Vagotomy and administration of antagonists for CCK and nicotinic receptors significantly blunted the inhibitory effect of high-fat enteral nutrition on hemorrhagic shock-induced tumor necrosis factor-alpha and interleukin-6 release (P < 0.05). Furthermore, the protective effect of high-fat enteral nutrition on inflammation-induced intestinal permeability was abrogated by vagotomy and administration of antagonists for CCK and nicotinic receptors. These data reveal a novel neuroimmunologic pathway, controlled by nutrition, that may help to explain the intestinal hyporesponsiveness to dietary antigens, and shed new light on the functionality of nutrition.

Authors+Show Affiliations

Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, 6200 MD, Maastricht, Netherlands. m.luyer@ah.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16216887

Citation

Luyer, Misha D., et al. "Nutritional Stimulation of Cholecystokinin Receptors Inhibits Inflammation Via the Vagus Nerve." The Journal of Experimental Medicine, vol. 202, no. 8, 2005, pp. 1023-9.
Luyer MD, Greve JW, Hadfoune M, et al. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med. 2005;202(8):1023-9.
Luyer, M. D., Greve, J. W., Hadfoune, M., Jacobs, J. A., Dejong, C. H., & Buurman, W. A. (2005). Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. The Journal of Experimental Medicine, 202(8), 1023-9.
Luyer MD, et al. Nutritional Stimulation of Cholecystokinin Receptors Inhibits Inflammation Via the Vagus Nerve. J Exp Med. 2005 Oct 17;202(8):1023-9. PubMed PMID: 16216887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. AU - Luyer,Misha D, AU - Greve,Jan Willem M, AU - Hadfoune,M'hamed, AU - Jacobs,Jan A, AU - Dejong,Cornelis H, AU - Buurman,Wim A, Y1 - 2005/10/10/ PY - 2005/10/12/pubmed PY - 2006/5/4/medline PY - 2005/10/12/entrez SP - 1023 EP - 9 JF - The Journal of experimental medicine JO - J Exp Med VL - 202 IS - 8 N2 - The immune system in vertebrates senses exogenous and endogenous danger signals by way of complex cellular and humoral processes, and responds with an inflammatory reaction to combat putative attacks. A strong protective immunity is imperative to prevent invasion of pathogens; however, equivalent responses to commensal flora and dietary components in the intestine have to be avoided. The autonomic nervous system plays an important role in sensing luminal contents in the gut by way of hard-wired connections and chemical messengers, such as cholecystokinin (CCK). Here, we report that ingestion of dietary fat stimulates CCK receptors, and leads to attenuation of the inflammatory response by way of the efferent vagus nerve and nicotinic receptors. Vagotomy and administration of antagonists for CCK and nicotinic receptors significantly blunted the inhibitory effect of high-fat enteral nutrition on hemorrhagic shock-induced tumor necrosis factor-alpha and interleukin-6 release (P < 0.05). Furthermore, the protective effect of high-fat enteral nutrition on inflammation-induced intestinal permeability was abrogated by vagotomy and administration of antagonists for CCK and nicotinic receptors. These data reveal a novel neuroimmunologic pathway, controlled by nutrition, that may help to explain the intestinal hyporesponsiveness to dietary antigens, and shed new light on the functionality of nutrition. SN - 0022-1007 UR - https://www.unboundmedicine.com/medline/citation/16216887/Nutritional_stimulation_of_cholecystokinin_receptors_inhibits_inflammation_via_the_vagus_nerve_ L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20042397 DB - PRIME DP - Unbound Medicine ER -