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Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.

Abstract

BACKGROUND

Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia.

OBJECTIVE

To investigate the relation between midlife body mass index and clustering of vascular risk factors and subsequent dementia and AD.

DESIGN AND SETTING

Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 individuals (73%) aged 65 to 79 years participated in the reexamination in 1998.

MAIN OUTCOME MEASURES

Dementia and AD.

RESULTS

Obesity at midlife (body mass index>30 kg/m2) was associated with the risk of dementia and AD even after adjusting for sociodemographic variables (odds ratio [OR], 2.4 [95% confidence interval (CI), 1.2-5.1]). The association was somewhat modified by further adjusting for midlife blood pressure, total cholesterol level, and smoking (OR, 2.1 [95% CI, 1.0-4.6]) and also for apolipoprotein E genotype and history of vascular disorders (OR, 1.9 [95% CI, 0.8-4.6]). Midlife obesity, high total cholesterol level, and high systolic blood pressure were all significant risk factors for dementia with ORs of around 2 for each factor, and they increased the risk additively (OR, 6.2 for the combination).

CONCLUSIONS

Obesity at midlife is associated with an increased risk of dementia and AD later in life. Clustering of vascular risk factors increases the risk in an additive manner. The role of weight reduction for the prevention of dementia needs to be further investigated.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden. miia.kivipelto@neurotec.ki.se

    , , , , , , , ,

    Source

    Archives of neurology 62:10 2005 Oct pg 1556-60

    MeSH

    Age Factors
    Aged
    Alzheimer Disease
    Body Mass Index
    Cholesterol
    Dementia
    Female
    Humans
    Hypertension
    Male
    Middle Aged
    Obesity
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16216938

    Citation

    Kivipelto, Miia, et al. "Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease." Archives of Neurology, vol. 62, no. 10, 2005, pp. 1556-60.
    Kivipelto M, Ngandu T, Fratiglioni L, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 2005;62(10):1556-60.
    Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., ... Nissinen, A. (2005). Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Archives of Neurology, 62(10), pp. 1556-60.
    Kivipelto M, et al. Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease. Arch Neurol. 2005;62(10):1556-60. PubMed PMID: 16216938.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. AU - Kivipelto,Miia, AU - Ngandu,Tiia, AU - Fratiglioni,Laura, AU - Viitanen,Matti, AU - Kåreholt,Ingemar, AU - Winblad,Bengt, AU - Helkala,Eeva-Liisa, AU - Tuomilehto,Jaakko, AU - Soininen,Hilkka, AU - Nissinen,Aulikki, PY - 2005/10/12/pubmed PY - 2005/11/16/medline PY - 2005/10/12/entrez SP - 1556 EP - 60 JF - Archives of neurology JO - Arch. Neurol. VL - 62 IS - 10 N2 - BACKGROUND: Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia. OBJECTIVE: To investigate the relation between midlife body mass index and clustering of vascular risk factors and subsequent dementia and AD. DESIGN AND SETTING: Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 individuals (73%) aged 65 to 79 years participated in the reexamination in 1998. MAIN OUTCOME MEASURES: Dementia and AD. RESULTS: Obesity at midlife (body mass index>30 kg/m2) was associated with the risk of dementia and AD even after adjusting for sociodemographic variables (odds ratio [OR], 2.4 [95% confidence interval (CI), 1.2-5.1]). The association was somewhat modified by further adjusting for midlife blood pressure, total cholesterol level, and smoking (OR, 2.1 [95% CI, 1.0-4.6]) and also for apolipoprotein E genotype and history of vascular disorders (OR, 1.9 [95% CI, 0.8-4.6]). Midlife obesity, high total cholesterol level, and high systolic blood pressure were all significant risk factors for dementia with ORs of around 2 for each factor, and they increased the risk additively (OR, 6.2 for the combination). CONCLUSIONS: Obesity at midlife is associated with an increased risk of dementia and AD later in life. Clustering of vascular risk factors increases the risk in an additive manner. The role of weight reduction for the prevention of dementia needs to be further investigated. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16216938/Obesity_and_vascular_risk_factors_at_midlife_and_the_risk_of_dementia_and_Alzheimer_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.62.10.1556 DB - PRIME DP - Unbound Medicine ER -