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The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998-2001.
Arch Intern Med. 2005 Oct 10; 165(18):2069-76.AI

Abstract

BACKGROUND

Polypharmacy-the concurrent prescription of multiple medications-is a salient consideration in the care of older patients with heart failure. Little is known, however, about the complexity and financial burden of medical therapy in this population.

METHODS

This is a study of the chronic medications prescribed at hospital discharge to patients 65 years or older hospitalized for heart failure in 2 cohorts separated by 27 months (April 1998-March 1999, n = 31 602; July 2000-June 2001, n = 30,774). Three utilization measures were assessed: the number of drugs, the estimated number of doses per day, and the estimated annual costs using the same cost standard (2003 average wholesale prices) for both samples. Utilization associated with population characteristics and between time frames was assessed in multivariable models.

RESULTS

In 1998-1999, the mean number of drugs was 6.8, representing 10.1 doses daily at a cost of 3142 dollars/y, increasing to 7.5 drugs, 11.1 doses daily and 3823 dollars/y in 2000-2001 (P<.001 for all comparisons). After adjustment, the number of drugs increased by 12% and costs by 24% between samples. Factors associated with greater complexity and cost included diabetes (1.6 additional drugs and 1094 dollars/y additional cost), prior revascularization (1.3 drugs, 1154 dollars/y), and chronic lung disease (1.2 drugs, 814 dollars/y). Younger age and white race were also associated with more drugs and higher costs.

CONCLUSIONS

The drug treatment of older patients with heart failure is characterized by rapidly increasing complexity and cost. Efforts should be directed toward optimizing the complex drug regimens of elderly patients with heart failure and multiple comorbidities.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Denver Health Medical Center, CO 80204, USA. fred.masoudi@uchsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16216996

Citation

Masoudi, Frederick A., et al. "The Complexity and Cost of Drug Regimens of Older Patients Hospitalized With Heart Failure in the United States, 1998-2001." Archives of Internal Medicine, vol. 165, no. 18, 2005, pp. 2069-76.
Masoudi FA, Baillie CA, Wang Y, et al. The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998-2001. Arch Intern Med. 2005;165(18):2069-76.
Masoudi, F. A., Baillie, C. A., Wang, Y., Bradford, W. D., Steiner, J. F., Havranek, E. P., Foody, J. M., & Krumholz, H. M. (2005). The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998-2001. Archives of Internal Medicine, 165(18), 2069-76.
Masoudi FA, et al. The Complexity and Cost of Drug Regimens of Older Patients Hospitalized With Heart Failure in the United States, 1998-2001. Arch Intern Med. 2005 Oct 10;165(18):2069-76. PubMed PMID: 16216996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998-2001. AU - Masoudi,Frederick A, AU - Baillie,Charles A, AU - Wang,Yongfei, AU - Bradford,W David, AU - Steiner,John F, AU - Havranek,Edward P, AU - Foody,JoAnne Micale, AU - Krumholz,Harlan M, PY - 2005/10/12/pubmed PY - 2005/11/15/medline PY - 2005/10/12/entrez SP - 2069 EP - 76 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 165 IS - 18 N2 - BACKGROUND: Polypharmacy-the concurrent prescription of multiple medications-is a salient consideration in the care of older patients with heart failure. Little is known, however, about the complexity and financial burden of medical therapy in this population. METHODS: This is a study of the chronic medications prescribed at hospital discharge to patients 65 years or older hospitalized for heart failure in 2 cohorts separated by 27 months (April 1998-March 1999, n = 31 602; July 2000-June 2001, n = 30,774). Three utilization measures were assessed: the number of drugs, the estimated number of doses per day, and the estimated annual costs using the same cost standard (2003 average wholesale prices) for both samples. Utilization associated with population characteristics and between time frames was assessed in multivariable models. RESULTS: In 1998-1999, the mean number of drugs was 6.8, representing 10.1 doses daily at a cost of 3142 dollars/y, increasing to 7.5 drugs, 11.1 doses daily and 3823 dollars/y in 2000-2001 (P<.001 for all comparisons). After adjustment, the number of drugs increased by 12% and costs by 24% between samples. Factors associated with greater complexity and cost included diabetes (1.6 additional drugs and 1094 dollars/y additional cost), prior revascularization (1.3 drugs, 1154 dollars/y), and chronic lung disease (1.2 drugs, 814 dollars/y). Younger age and white race were also associated with more drugs and higher costs. CONCLUSIONS: The drug treatment of older patients with heart failure is characterized by rapidly increasing complexity and cost. Efforts should be directed toward optimizing the complex drug regimens of elderly patients with heart failure and multiple comorbidities. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16216996/The_complexity_and_cost_of_drug_regimens_of_older_patients_hospitalized_with_heart_failure_in_the_United_States_1998_2001_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.165.18.2069 DB - PRIME DP - Unbound Medicine ER -