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Serum cholesterol and risk of Alzheimer disease: a community-based cohort study.
Neurology 2005; 65(7):1045-50Neur

Abstract

OBJECTIVES

To examine the association of serum total cholesterol (TC) and high density lipoprotein (HDL) levels and subsequent incidence of dementia and Alzheimer disease (AD) in a population-based cohort study.

METHODS

A cohort of cognitively intact persons, aged 65 and older, was randomly selected from Group Health Cooperative (GHC), a large health maintenance organization, and was assessed biennially for dementia. Premorbid levels of TC and HDL were obtained from a computerized clinical laboratory database at GHC. Cox proportional hazards regression was used to calculate hazard ratios (HR, 95% CI) for dementia and AD associated with quartiles of TC and HDL levels.

RESULTS

Of the 2,356 eligible participants, 2,141 had at least one serum TC measure prior to the initial enrollment. Using the lowest TC quartiles as the reference group, the HR in the highest TC quartiles was not significantly elevated for dementia (1.16, 0.81 to 1.67) or for AD (1.00, 0.61 to 1.62) after adjusting for age, sex, education, baseline cognition, vascular comorbidities, body mass index, and lipid-lowering agent use. Serum HDL showed a similar lack of significant association with risk of dementia or AD. Models that included the presence of one or more APOE-epsilon4 alleles showed a typical association of epsilon4 with AD risk. This association was not materially modified by inclusion of TC level.

CONCLUSION

The data do not support an association between serum total cholesterol or high density lipoprotein in late life and subsequent risk of dementia or Alzheimer disease (AD). The increased risk of AD with APOE-epsilon4 is probably not mediated by serum total cholesterol levels.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA. gli@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16217057

Citation

Li, G, et al. "Serum Cholesterol and Risk of Alzheimer Disease: a Community-based Cohort Study." Neurology, vol. 65, no. 7, 2005, pp. 1045-50.
Li G, Shofer JB, Kukull WA, et al. Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. Neurology. 2005;65(7):1045-50.
Li, G., Shofer, J. B., Kukull, W. A., Peskind, E. R., Tsuang, D. W., Breitner, J. C., ... Larson, E. B. (2005). Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. Neurology, 65(7), pp. 1045-50.
Li G, et al. Serum Cholesterol and Risk of Alzheimer Disease: a Community-based Cohort Study. Neurology. 2005 Oct 11;65(7):1045-50. PubMed PMID: 16217057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. AU - Li,G, AU - Shofer,J B, AU - Kukull,W A, AU - Peskind,E R, AU - Tsuang,D W, AU - Breitner,J C S, AU - McCormick,W, AU - Bowen,J D, AU - Teri,L, AU - Schellenberg,G D, AU - Larson,E B, PY - 2005/10/12/pubmed PY - 2006/3/10/medline PY - 2005/10/12/entrez SP - 1045 EP - 50 JF - Neurology JO - Neurology VL - 65 IS - 7 N2 - OBJECTIVES: To examine the association of serum total cholesterol (TC) and high density lipoprotein (HDL) levels and subsequent incidence of dementia and Alzheimer disease (AD) in a population-based cohort study. METHODS: A cohort of cognitively intact persons, aged 65 and older, was randomly selected from Group Health Cooperative (GHC), a large health maintenance organization, and was assessed biennially for dementia. Premorbid levels of TC and HDL were obtained from a computerized clinical laboratory database at GHC. Cox proportional hazards regression was used to calculate hazard ratios (HR, 95% CI) for dementia and AD associated with quartiles of TC and HDL levels. RESULTS: Of the 2,356 eligible participants, 2,141 had at least one serum TC measure prior to the initial enrollment. Using the lowest TC quartiles as the reference group, the HR in the highest TC quartiles was not significantly elevated for dementia (1.16, 0.81 to 1.67) or for AD (1.00, 0.61 to 1.62) after adjusting for age, sex, education, baseline cognition, vascular comorbidities, body mass index, and lipid-lowering agent use. Serum HDL showed a similar lack of significant association with risk of dementia or AD. Models that included the presence of one or more APOE-epsilon4 alleles showed a typical association of epsilon4 with AD risk. This association was not materially modified by inclusion of TC level. CONCLUSION: The data do not support an association between serum total cholesterol or high density lipoprotein in late life and subsequent risk of dementia or Alzheimer disease (AD). The increased risk of AD with APOE-epsilon4 is probably not mediated by serum total cholesterol levels. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16217057/Serum_cholesterol_and_risk_of_Alzheimer_disease:_a_community_based_cohort_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16217057 DB - PRIME DP - Unbound Medicine ER -