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Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary intervention.
Diabetes Obes Metab. 2005 Nov; 7(6):745-54.DO

Abstract

AIM

The aim of this study was to investigate the role of skeletal muscle fibre type in the regulation of glucose metabolism in middle-aged obese subjects with impaired glucose tolerance (IGT) during a 2-year exercise and dietary intervention.

METHODS

Muscle biopsies (musculus vastus lateralis) were taken from 22 subjects belonging to the intervention group of the Finnish Diabetes Prevention Study [1]. According to their myosin heavy chain (MHC) profile at the baseline, the subjects were divided into two groups: IGT(slow) (n=10) with a high proportion of MHC I isoforms and IGT(fast) (n=12) with a high proportion of MHC II isoforms in the vastus lateralis muscle. The intervention consisted of dietary counselling, strength and power training and/or aerobic exercise. The amount of exercise was the same in both groups; the exercise frequency was 5.1+/-2.7 h/week in the IGT(slow) and 5.1+/-2.8 h/week in the IGT(fast) group.

RESULTS

Fasting glucose (p<0.05), 2-h glucose (p<0.05), fasting insulin (p<0.05), haemoglobin A1c (HbA(1c)) (p<0.01) and insulin resistance (p<0.05) [homeostasis model assessment for insulin resistance (HOMA-IR)] decreased in the IGT(fast) group, whereas only the 2-h glucose and HbA(1c) concentrations decreased in the IGT(slow) group. The amount of the glycogen synthase kinase-3-alphabeta (GSK-3-alphabeta) decreased in the IGT(fast) group (p<0.05). Exercise training increased the lactate dehydrogenase (LDH) (p<0.01), LDH-1 (p<0.05) and citrate synthase (CS) (p<0.05) activities in the vastus lateralis muscle in the IGT(slow) group, but only the CS activity (p<0.05) in the IGT(fast) group.

CONCLUSIONS

The glucose metabolism improved both in the IGT(slow) and IGT(fast) group during the 2-year exercise and dietary intervention. The change was more prominent in the IGT(fast) group than in the IGT(slow) group, associated with the decrease of the GSK-alphabeta protein expression in skeletal muscle. The exercise training improved both glycolytic and oxidative capacity in the vastus lateralis muscle. The glycolytic capacity improved in the IGT(slow) group and the oxidative capacity in both groups.

Authors+Show Affiliations

Department of Physiology, University of Kuopio, Kuopio, Finland. mika.venojarvi@btk.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16219019

Citation

Venojärvi, M, et al. "Role of Skeletal Muscle-fibre Type in Regulation of Glucose Metabolism in Middle-aged Subjects With Impaired Glucose Tolerance During a Long-term Exercise and Dietary Intervention." Diabetes, Obesity & Metabolism, vol. 7, no. 6, 2005, pp. 745-54.
Venojärvi M, Puhke R, Hämäläinen H, et al. Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary intervention. Diabetes Obes Metab. 2005;7(6):745-54.
Venojärvi, M., Puhke, R., Hämäläinen, H., Marniemi, J., Rastas, M., Rusko, H., Nuutila, P., Hänninen, O., & Aunola, S. (2005). Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary intervention. Diabetes, Obesity & Metabolism, 7(6), 745-54.
Venojärvi M, et al. Role of Skeletal Muscle-fibre Type in Regulation of Glucose Metabolism in Middle-aged Subjects With Impaired Glucose Tolerance During a Long-term Exercise and Dietary Intervention. Diabetes Obes Metab. 2005;7(6):745-54. PubMed PMID: 16219019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary intervention. AU - Venojärvi,M, AU - Puhke,R, AU - Hämäläinen,H, AU - Marniemi,J, AU - Rastas,M, AU - Rusko,H, AU - Nuutila,P, AU - Hänninen,O, AU - Aunola,S, PY - 2005/10/13/pubmed PY - 2006/4/4/medline PY - 2005/10/13/entrez SP - 745 EP - 54 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 7 IS - 6 N2 - AIM: The aim of this study was to investigate the role of skeletal muscle fibre type in the regulation of glucose metabolism in middle-aged obese subjects with impaired glucose tolerance (IGT) during a 2-year exercise and dietary intervention. METHODS: Muscle biopsies (musculus vastus lateralis) were taken from 22 subjects belonging to the intervention group of the Finnish Diabetes Prevention Study [1]. According to their myosin heavy chain (MHC) profile at the baseline, the subjects were divided into two groups: IGT(slow) (n=10) with a high proportion of MHC I isoforms and IGT(fast) (n=12) with a high proportion of MHC II isoforms in the vastus lateralis muscle. The intervention consisted of dietary counselling, strength and power training and/or aerobic exercise. The amount of exercise was the same in both groups; the exercise frequency was 5.1+/-2.7 h/week in the IGT(slow) and 5.1+/-2.8 h/week in the IGT(fast) group. RESULTS: Fasting glucose (p<0.05), 2-h glucose (p<0.05), fasting insulin (p<0.05), haemoglobin A1c (HbA(1c)) (p<0.01) and insulin resistance (p<0.05) [homeostasis model assessment for insulin resistance (HOMA-IR)] decreased in the IGT(fast) group, whereas only the 2-h glucose and HbA(1c) concentrations decreased in the IGT(slow) group. The amount of the glycogen synthase kinase-3-alphabeta (GSK-3-alphabeta) decreased in the IGT(fast) group (p<0.05). Exercise training increased the lactate dehydrogenase (LDH) (p<0.01), LDH-1 (p<0.05) and citrate synthase (CS) (p<0.05) activities in the vastus lateralis muscle in the IGT(slow) group, but only the CS activity (p<0.05) in the IGT(fast) group. CONCLUSIONS: The glucose metabolism improved both in the IGT(slow) and IGT(fast) group during the 2-year exercise and dietary intervention. The change was more prominent in the IGT(fast) group than in the IGT(slow) group, associated with the decrease of the GSK-alphabeta protein expression in skeletal muscle. The exercise training improved both glycolytic and oxidative capacity in the vastus lateralis muscle. The glycolytic capacity improved in the IGT(slow) group and the oxidative capacity in both groups. SN - 1462-8902 UR - https://www.unboundmedicine.com/medline/citation/16219019/Role_of_skeletal_muscle_fibre_type_in_regulation_of_glucose_metabolism_in_middle_aged_subjects_with_impaired_glucose_tolerance_during_a_long_term_exercise_and_dietary_intervention_ L2 - https://doi.org/10.1111/j.1463-1326.2004.00466.x DB - PRIME DP - Unbound Medicine ER -