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Heritability of polycystic ovary syndrome in a Dutch twin-family study.

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases.

OBJECTIVE

In the present study, the heritability of PCOS was estimated.

DESIGN/PARTICIPANTS

Data from 1332 monozygotic twins (genetically identical) and 1873 dizygotic twins/singleton sisters of twins (who share on average 50% of their segregating genes) registered with The Netherlands Twin Register were used. PCOS was defined as less than nine menstrual cycles and acne or hirsutism in agreement with the 2003 Rotterdam consensus.

RESULTS

Results point to a strong contribution of familial factors to PCOS. The resemblance in monozygotic twin sisters (tetrachoric correlation 0.71) for PCOS was about twice as large as in dizygotic twin and other sisters (tetrachoric correlation 0.38). Univariate analyses point to strong contributions of genetic factors to the variance in PCOS. Next, a trivariate genetic analysis of oligomenorrhea, acne, and hirsutism was carried out. This analysis confirmed that the familial component in PCOS is due to genetic factors.

CONCLUSIONS

This study demonstrated a large influence of genetic factors to the pathogenesis of PCOS, justifying the search for susceptibility genes.

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  • Authors+Show Affiliations

    ,

    Department of Biological Psychology, Vrije Universiteit, van de Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. jm.vink@psy.vu.nl

    , ,

    Source

    MeSH

    Adult
    Diseases in Twins
    Female
    Humans
    Polycystic Ovary Syndrome
    Twin Studies as Topic
    Twins
    Twins, Dizygotic
    Twins, Monozygotic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16219714

    Citation

    Vink, J M., et al. "Heritability of Polycystic Ovary Syndrome in a Dutch Twin-family Study." The Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, 2006, pp. 2100-4.
    Vink JM, Sadrzadeh S, Lambalk CB, et al. Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab. 2006;91(6):2100-4.
    Vink, J. M., Sadrzadeh, S., Lambalk, C. B., & Boomsma, D. I. (2006). Heritability of polycystic ovary syndrome in a Dutch twin-family study. The Journal of Clinical Endocrinology and Metabolism, 91(6), pp. 2100-4.
    Vink JM, et al. Heritability of Polycystic Ovary Syndrome in a Dutch Twin-family Study. J Clin Endocrinol Metab. 2006;91(6):2100-4. PubMed PMID: 16219714.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Heritability of polycystic ovary syndrome in a Dutch twin-family study. AU - Vink,J M, AU - Sadrzadeh,S, AU - Lambalk,C B, AU - Boomsma,D I, Y1 - 2005/10/11/ PY - 2005/10/13/pubmed PY - 2006/6/30/medline PY - 2005/10/13/entrez SP - 2100 EP - 4 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 91 IS - 6 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases. OBJECTIVE: In the present study, the heritability of PCOS was estimated. DESIGN/PARTICIPANTS: Data from 1332 monozygotic twins (genetically identical) and 1873 dizygotic twins/singleton sisters of twins (who share on average 50% of their segregating genes) registered with The Netherlands Twin Register were used. PCOS was defined as less than nine menstrual cycles and acne or hirsutism in agreement with the 2003 Rotterdam consensus. RESULTS: Results point to a strong contribution of familial factors to PCOS. The resemblance in monozygotic twin sisters (tetrachoric correlation 0.71) for PCOS was about twice as large as in dizygotic twin and other sisters (tetrachoric correlation 0.38). Univariate analyses point to strong contributions of genetic factors to the variance in PCOS. Next, a trivariate genetic analysis of oligomenorrhea, acne, and hirsutism was carried out. This analysis confirmed that the familial component in PCOS is due to genetic factors. CONCLUSIONS: This study demonstrated a large influence of genetic factors to the pathogenesis of PCOS, justifying the search for susceptibility genes. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/16219714/full_citation L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2005-1494 DB - PRIME DP - Unbound Medicine ER -