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Significant negative impact of adjuvant chemotherapy on health-related quality of life (HR-QoL) in women with breast cancer treated by conserving surgery and postoperative 3-D radiotherapy. A prospective measurement.
Strahlenther Onkol. 2005 Oct; 181(10):645-51.SO

Abstract

PURPOSE

To prospectively assess health-related quality of life (HR-QoL) in women after conserving surgery for breast cancer during/after postoperative 3-D radiotherapy.

PATIENTS AND METHODS

109 consecutively treated patients were analyzed. HR-QoL was assessed at initiation (t1), end (t2), and 6 weeks after radiotherapy (t3) using the EORTC modules QLQ-C30/BR23. Patients were divided into three therapy groups. Group I comprised 41 patients (radiotherapy and adjuvant chemotherapy), group II 45 patients (radiotherapy and adjuvant hormonal therapy), and group III 23 patients (radiotherapy alone). Reliability was tested. Scale means were calculated. Univariate (ANOVA) and multivariate (MANCOVA) analyses were performed.

RESULTS

Reliability testing revealed mean Cronbach's alpha> 0.70 at all measurement points. ANOVA/MANCOVA statistics revealed significantly better HR-QoL for patients in group II versus I. Patients receiving radiotherapy alone (group III) showed the best results in HR-QoL. However, scale mean differences between groups II and III were not significant.

CONCLUSION

HR-QoL measurement using EORTC instruments during/after radiotherapy is reliable. Adjuvant chemotherapy significantly lowered HR-QoL versus hormones or radiotherapy alone. Chemotherapy patients did not recover longitudinally (from t1 to t3).

Authors+Show Affiliations

Clinic for Radiation Therapy (Radiooncology), University Hospital Schleswig-Holstein, Campus Kiel, Germany. galalae@onco.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16220403

Citation

Galalae, Razvan M., et al. "Significant Negative Impact of Adjuvant Chemotherapy On Health-related Quality of Life (HR-QoL) in Women With Breast Cancer Treated By Conserving Surgery and Postoperative 3-D Radiotherapy. a Prospective Measurement." Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [et Al], vol. 181, no. 10, 2005, pp. 645-51.
Galalae RM, Michel J, Siebmann JU, et al. Significant negative impact of adjuvant chemotherapy on health-related quality of life (HR-QoL) in women with breast cancer treated by conserving surgery and postoperative 3-D radiotherapy. A prospective measurement. Strahlenther Onkol. 2005;181(10):645-51.
Galalae, R. M., Michel, J., Siebmann, J. U., Küchler, T., Eilf, K., & Kimmig, B. (2005). Significant negative impact of adjuvant chemotherapy on health-related quality of life (HR-QoL) in women with breast cancer treated by conserving surgery and postoperative 3-D radiotherapy. A prospective measurement. Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [et Al], 181(10), 645-51.
Galalae RM, et al. Significant Negative Impact of Adjuvant Chemotherapy On Health-related Quality of Life (HR-QoL) in Women With Breast Cancer Treated By Conserving Surgery and Postoperative 3-D Radiotherapy. a Prospective Measurement. Strahlenther Onkol. 2005;181(10):645-51. PubMed PMID: 16220403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant negative impact of adjuvant chemotherapy on health-related quality of life (HR-QoL) in women with breast cancer treated by conserving surgery and postoperative 3-D radiotherapy. A prospective measurement. AU - Galalae,Razvan M, AU - Michel,Jan, AU - Siebmann,Jens Ullrich, AU - Küchler,Thomas, AU - Eilf,Kirsten, AU - Kimmig,Bernard, PY - 2004/12/14/received PY - 2005/08/01/revised PY - 2005/10/13/pubmed PY - 2006/3/3/medline PY - 2005/10/13/entrez SP - 645 EP - 51 JF - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] JO - Strahlenther Onkol VL - 181 IS - 10 N2 - PURPOSE: To prospectively assess health-related quality of life (HR-QoL) in women after conserving surgery for breast cancer during/after postoperative 3-D radiotherapy. PATIENTS AND METHODS: 109 consecutively treated patients were analyzed. HR-QoL was assessed at initiation (t1), end (t2), and 6 weeks after radiotherapy (t3) using the EORTC modules QLQ-C30/BR23. Patients were divided into three therapy groups. Group I comprised 41 patients (radiotherapy and adjuvant chemotherapy), group II 45 patients (radiotherapy and adjuvant hormonal therapy), and group III 23 patients (radiotherapy alone). Reliability was tested. Scale means were calculated. Univariate (ANOVA) and multivariate (MANCOVA) analyses were performed. RESULTS: Reliability testing revealed mean Cronbach's alpha> 0.70 at all measurement points. ANOVA/MANCOVA statistics revealed significantly better HR-QoL for patients in group II versus I. Patients receiving radiotherapy alone (group III) showed the best results in HR-QoL. However, scale mean differences between groups II and III were not significant. CONCLUSION: HR-QoL measurement using EORTC instruments during/after radiotherapy is reliable. Adjuvant chemotherapy significantly lowered HR-QoL versus hormones or radiotherapy alone. Chemotherapy patients did not recover longitudinally (from t1 to t3). SN - 0179-7158 UR - https://www.unboundmedicine.com/medline/citation/16220403/Significant_negative_impact_of_adjuvant_chemotherapy_on_health_related_quality_of_life__HR_QoL__in_women_with_breast_cancer_treated_by_conserving_surgery_and_postoperative_3_D_radiotherapy__A_prospective_measurement_ L2 - https://dx.doi.org/10.1007/s00066-005-1403-x DB - PRIME DP - Unbound Medicine ER -