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Effect of a 24-hour infusion of an isotonic electrolyte replacement fluid on the renal clearance of electrolytes in healthy neonatal foals.
J Am Vet Med Assoc 2005; 227(7):1123-9JA

Abstract

OBJECTIVE

To determine the effects of a 24-hour infusion of an isotonic electrolyte replacement fluid (IERF) on weight, serum and urine electrolyte concentrations, and other clinicopathologic variables in healthy neonatal foals.

ANIMALS

4 healthy 4-day-old foals.

DESIGN

Prospective study.

PROCEDURE

An IERF was administered to each foal at an estimated rate of 80 mL/kg/d (36.4 mL/lb/d) for 24 hours. Body weight was measured before and after the infusion period. Urine was collected via catheter during 4-hour periods; blood samples were collected at 4-hour intervals. Variables including urine production; urine and serum osmolalities; sodium, potassium, and chloride concentrations in urine and serum; urine and serum creatinine concentrations; urine osmolality-to-serum osmolality ratio (OsmR); transtubular potassium gradient (TTKG); and percentage creatinine clearance (Cr(cl)) of electrolytes were recorded at 0, 4, 8, 12, 16, 20, and 24 hours during the infusion period. Immediately after the study period, net fluid and whole-body electrolyte changes from baseline values were calculated.

RESULTS

Compared with baseline values, urine and serum sodium and chloride serum concentrations, urine and serum osmolalities, OsmR, and percentage Cr(cl) of sodium and chloride were significantly increased at various time points during the infusion; urine production did not change significantly. After 24 hours, weight, TTKG, serum creatinine concentration, and whole-body potassium had significantly decreased from baseline values.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggest that administration of an IERF containing a physiologic concentration of sodium may not be appropriate for use in neonatal foals that require maintenance fluid therapy.

Authors+Show Affiliations

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16220674

Citation

Buchanan, Benjamin R., et al. "Effect of a 24-hour Infusion of an Isotonic Electrolyte Replacement Fluid On the Renal Clearance of Electrolytes in Healthy Neonatal Foals." Journal of the American Veterinary Medical Association, vol. 227, no. 7, 2005, pp. 1123-9.
Buchanan BR, Sommardahl CS, Rohrbach BW, et al. Effect of a 24-hour infusion of an isotonic electrolyte replacement fluid on the renal clearance of electrolytes in healthy neonatal foals. J Am Vet Med Assoc. 2005;227(7):1123-9.
Buchanan, B. R., Sommardahl, C. S., Rohrbach, B. W., & Andrews, F. M. (2005). Effect of a 24-hour infusion of an isotonic electrolyte replacement fluid on the renal clearance of electrolytes in healthy neonatal foals. Journal of the American Veterinary Medical Association, 227(7), pp. 1123-9.
Buchanan BR, et al. Effect of a 24-hour Infusion of an Isotonic Electrolyte Replacement Fluid On the Renal Clearance of Electrolytes in Healthy Neonatal Foals. J Am Vet Med Assoc. 2005 Oct 1;227(7):1123-9. PubMed PMID: 16220674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a 24-hour infusion of an isotonic electrolyte replacement fluid on the renal clearance of electrolytes in healthy neonatal foals. AU - Buchanan,Benjamin R, AU - Sommardahl,Carla S, AU - Rohrbach,Barton W, AU - Andrews,Frank M, PY - 2005/10/14/pubmed PY - 2005/11/16/medline PY - 2005/10/14/entrez SP - 1123 EP - 9 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 227 IS - 7 N2 - OBJECTIVE: To determine the effects of a 24-hour infusion of an isotonic electrolyte replacement fluid (IERF) on weight, serum and urine electrolyte concentrations, and other clinicopathologic variables in healthy neonatal foals. ANIMALS: 4 healthy 4-day-old foals. DESIGN: Prospective study. PROCEDURE: An IERF was administered to each foal at an estimated rate of 80 mL/kg/d (36.4 mL/lb/d) for 24 hours. Body weight was measured before and after the infusion period. Urine was collected via catheter during 4-hour periods; blood samples were collected at 4-hour intervals. Variables including urine production; urine and serum osmolalities; sodium, potassium, and chloride concentrations in urine and serum; urine and serum creatinine concentrations; urine osmolality-to-serum osmolality ratio (OsmR); transtubular potassium gradient (TTKG); and percentage creatinine clearance (Cr(cl)) of electrolytes were recorded at 0, 4, 8, 12, 16, 20, and 24 hours during the infusion period. Immediately after the study period, net fluid and whole-body electrolyte changes from baseline values were calculated. RESULTS: Compared with baseline values, urine and serum sodium and chloride serum concentrations, urine and serum osmolalities, OsmR, and percentage Cr(cl) of sodium and chloride were significantly increased at various time points during the infusion; urine production did not change significantly. After 24 hours, weight, TTKG, serum creatinine concentration, and whole-body potassium had significantly decreased from baseline values. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that administration of an IERF containing a physiologic concentration of sodium may not be appropriate for use in neonatal foals that require maintenance fluid therapy. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/16220674/Effect_of_a_24_hour_infusion_of_an_isotonic_electrolyte_replacement_fluid_on_the_renal_clearance_of_electrolytes_in_healthy_neonatal_foals_ L2 - http://avmajournals.avma.org/doi/full/10.2460/javma.2005.227.1123?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -