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Intraepithelial mucinous carcinoma arising in an endocervical-type mucinous polypoid adenomyoma of the uterine corpus: a case report.
J Reprod Med. 2005 Aug; 50(8):643-6.JR

Abstract

BACKGROUND

Benign endocervical-type mucinous adenomyoma arising in the uterine corpus is a rare entity. We report a case of intraepithelial mucinous adenocarcinoma arising in an endocervical-type mucinous adenomyoma of the uterine corpus in a previously healthy woman.

CASE

A 55-year-old, white woman presented with postmenopausal bleeding. Uterine leiomyomas and endometrial polyps were suggested by ultrasonography. Endometrial curettage showed multiple polypoid tissue fragments, each composed of glands lined with tall columnar endocervical-type mucinous epithelium lying within a background of endometrial-type stroma and smooth muscle fibers. The mucinous glandular epithelium showed a spectrum of architectural and cytologic changes ranging from benign to severe atypia and occasional back-to-back cribriform glands, consistent with adenocarcinoma. The surrounding smooth muscle fibers and endometrial stromal cells were benign. A diagnosis was made of intraepithelial adenocarcinoma arising in a mucinous adenomyoma in the uterine corpus.

CONCLUSION

Endocervical-type mucinous adenomyoma, although previously reported as a benign entity, may contain areas of adenocarcinoma.

Authors+Show Affiliations

Department of Pathology, Women & Infants Hospital and Brown University Medical School, Providence, RI 02905-2499, USA. mquddus@wihri.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16220776

Citation

Quddus, M Ruhul, et al. "Intraepithelial Mucinous Carcinoma Arising in an Endocervical-type Mucinous Polypoid Adenomyoma of the Uterine Corpus: a Case Report." The Journal of Reproductive Medicine, vol. 50, no. 8, 2005, pp. 643-6.
Quddus MR, Zhang C, Sung CJ, et al. Intraepithelial mucinous carcinoma arising in an endocervical-type mucinous polypoid adenomyoma of the uterine corpus: a case report. J Reprod Med. 2005;50(8):643-6.
Quddus, M. R., Zhang, C., Sung, C. J., Ramos, D., & Lawrence, W. D. (2005). Intraepithelial mucinous carcinoma arising in an endocervical-type mucinous polypoid adenomyoma of the uterine corpus: a case report. The Journal of Reproductive Medicine, 50(8), 643-6.
Quddus MR, et al. Intraepithelial Mucinous Carcinoma Arising in an Endocervical-type Mucinous Polypoid Adenomyoma of the Uterine Corpus: a Case Report. J Reprod Med. 2005;50(8):643-6. PubMed PMID: 16220776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraepithelial mucinous carcinoma arising in an endocervical-type mucinous polypoid adenomyoma of the uterine corpus: a case report. AU - Quddus,M Ruhul, AU - Zhang,Cunxian, AU - Sung,C James, AU - Ramos,Donald, AU - Lawrence,W Dwayne, PY - 2005/10/14/pubmed PY - 2006/3/1/medline PY - 2005/10/14/entrez SP - 643 EP - 6 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 50 IS - 8 N2 - BACKGROUND: Benign endocervical-type mucinous adenomyoma arising in the uterine corpus is a rare entity. We report a case of intraepithelial mucinous adenocarcinoma arising in an endocervical-type mucinous adenomyoma of the uterine corpus in a previously healthy woman. CASE: A 55-year-old, white woman presented with postmenopausal bleeding. Uterine leiomyomas and endometrial polyps were suggested by ultrasonography. Endometrial curettage showed multiple polypoid tissue fragments, each composed of glands lined with tall columnar endocervical-type mucinous epithelium lying within a background of endometrial-type stroma and smooth muscle fibers. The mucinous glandular epithelium showed a spectrum of architectural and cytologic changes ranging from benign to severe atypia and occasional back-to-back cribriform glands, consistent with adenocarcinoma. The surrounding smooth muscle fibers and endometrial stromal cells were benign. A diagnosis was made of intraepithelial adenocarcinoma arising in a mucinous adenomyoma in the uterine corpus. CONCLUSION: Endocervical-type mucinous adenomyoma, although previously reported as a benign entity, may contain areas of adenocarcinoma. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/16220776/Intraepithelial_mucinous_carcinoma_arising_in_an_endocervical_type_mucinous_polypoid_adenomyoma_of_the_uterine_corpus:_a_case_report_ L2 - https://medlineplus.gov/uterinecancer.html DB - PRIME DP - Unbound Medicine ER -