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Objective evaluation for severity of atopic dermatitis by morphologic study of skin surface contours.
Skin Res Technol 2005; 11(4):272-80SR

Abstract

BACKGROUND/AIMS

Wide variation in outcome methodology can make the interpretation of patient outcomes confusing and the comparison of the results of different studies almost impossible. It is important to objectively measure and record the severity of atopic dermatitis (AD) for routine clinical practice and research. The aim of this study was to evaluate whether morphologic study of skin surface contours might be helpful to objectively quantify the severity of AD.

METHODS

Thirty atopic patients (12 females, 18 males) participated in this study. Moisturizer was applied twice daily for 2 weeks. Bioengineering methods such as D-Squame, corneometer, evaporimeter, and spectrophotometer were measured at the start of the study and after 1 week and 2 weeks. In addition, we assessed moisturizer effects after 3 h of moisturizer application.The stereoimage optical topometer (SOT) based on a new concept of stereoimage was applied for this study. We compared SOT, other bioengineering methods, and the severity scoring of atopic dermatitis (SCORAD) index.

RESULTS

After 3 h of application with moisturizer, the results measured by SOT, conventional optical profilometer (COP), D-Squame, and corneometer showed significant differences (P<0.05). After 1 and 2 weeks, there were significant changes in the results measured by SOT, COP, D-Squame, corneometer, spectrophotometer, and SCORAD index. We observed a significant correlation between bioengineering methods and the SCORAD index (P<0.05).

CONCLUSION

These data indicate that morphologic study of skin surface contours are useful in evaluating of AD severity. If we would combine methods to evaluate the physiologic changes and those such as SOT to measure the morphological changes of skin surface, we could evaluate more objectively and quantitatively the severity of AD.

Authors+Show Affiliations

Department of Dermatology, Korea University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16221144

Citation

Son, Sang W., et al. "Objective Evaluation for Severity of Atopic Dermatitis By Morphologic Study of Skin Surface Contours." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 11, no. 4, 2005, pp. 272-80.
Son SW, Park SY, Ha SH, et al. Objective evaluation for severity of atopic dermatitis by morphologic study of skin surface contours. Skin Res Technol. 2005;11(4):272-80.
Son, S. W., Park, S. Y., Ha, S. H., Park, G. M., Kim, M. G., Moon, J. S., ... Oh, C. H. (2005). Objective evaluation for severity of atopic dermatitis by morphologic study of skin surface contours. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 11(4), pp. 272-80.
Son SW, et al. Objective Evaluation for Severity of Atopic Dermatitis By Morphologic Study of Skin Surface Contours. Skin Res Technol. 2005;11(4):272-80. PubMed PMID: 16221144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Objective evaluation for severity of atopic dermatitis by morphologic study of skin surface contours. AU - Son,Sang W, AU - Park,Sang Y, AU - Ha,Seung H, AU - Park,Gyu M, AU - Kim,Min G, AU - Moon,Jong S, AU - Yoo,Dong S, AU - Oh,Chil H, PY - 2005/10/14/pubmed PY - 2006/1/21/medline PY - 2005/10/14/entrez SP - 272 EP - 80 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 11 IS - 4 N2 - BACKGROUND/AIMS: Wide variation in outcome methodology can make the interpretation of patient outcomes confusing and the comparison of the results of different studies almost impossible. It is important to objectively measure and record the severity of atopic dermatitis (AD) for routine clinical practice and research. The aim of this study was to evaluate whether morphologic study of skin surface contours might be helpful to objectively quantify the severity of AD. METHODS: Thirty atopic patients (12 females, 18 males) participated in this study. Moisturizer was applied twice daily for 2 weeks. Bioengineering methods such as D-Squame, corneometer, evaporimeter, and spectrophotometer were measured at the start of the study and after 1 week and 2 weeks. In addition, we assessed moisturizer effects after 3 h of moisturizer application.The stereoimage optical topometer (SOT) based on a new concept of stereoimage was applied for this study. We compared SOT, other bioengineering methods, and the severity scoring of atopic dermatitis (SCORAD) index. RESULTS: After 3 h of application with moisturizer, the results measured by SOT, conventional optical profilometer (COP), D-Squame, and corneometer showed significant differences (P<0.05). After 1 and 2 weeks, there were significant changes in the results measured by SOT, COP, D-Squame, corneometer, spectrophotometer, and SCORAD index. We observed a significant correlation between bioengineering methods and the SCORAD index (P<0.05). CONCLUSION: These data indicate that morphologic study of skin surface contours are useful in evaluating of AD severity. If we would combine methods to evaluate the physiologic changes and those such as SOT to measure the morphological changes of skin surface, we could evaluate more objectively and quantitatively the severity of AD. SN - 0909-752X UR - https://www.unboundmedicine.com/medline/citation/16221144/Objective_evaluation_for_severity_of_atopic_dermatitis_by_morphologic_study_of_skin_surface_contours_ L2 - https://doi.org/10.1111/j.0909-725X.2005.00124.x DB - PRIME DP - Unbound Medicine ER -