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White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans.
Am J Epidemiol 2005; 162(11):1062-9AJ

Abstract

The authors conducted a 10-year prospective cohort study of mortality in relation to white blood cell counts of 437,454 Koreans, aged 40-95 years, who received health insurance from the National Health Insurance Corporation and were medically evaluated in 1993 or 1995, with white blood cell measurement. The main outcome measures were mortality from all causes, all cancers, and all atherosclerotic cardiovascular diseases (ASCVD). Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models with adjustment for age and potential confounders. During follow-up, 48,757 deaths occurred, with 15,507 deaths from cancer and 11,676 from ASCVD. For men and women, white blood cell count was associated with all-cause mortality and ASCVD mortality but not with cancer mortality. In healthy nonsmokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was observed in men (highest vs. lowest quintile: hazard ratio = 2.10, 95% confidence interval: 1.50, 2.94) and in women (hazard ratio = 1.35, 95% confidence interval: 1.17, 1.56). In healthy smokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was also observed in men (highest vs. lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yumc.yonsei.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16221804

Citation

Jee, Sun Ha, et al. "White Blood Cell Count and Risk for All-cause, Cardiovascular, and Cancer Mortality in a Cohort of Koreans." American Journal of Epidemiology, vol. 162, no. 11, 2005, pp. 1062-9.
Jee SH, Park JY, Kim HS, et al. White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans. Am J Epidemiol. 2005;162(11):1062-9.
Jee, S. H., Park, J. Y., Kim, H. S., Lee, T. Y., & Samet, J. M. (2005). White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans. American Journal of Epidemiology, 162(11), pp. 1062-9.
Jee SH, et al. White Blood Cell Count and Risk for All-cause, Cardiovascular, and Cancer Mortality in a Cohort of Koreans. Am J Epidemiol. 2005 Dec 1;162(11):1062-9. PubMed PMID: 16221804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans. AU - Jee,Sun Ha, AU - Park,Jung Yong, AU - Kim,Hyon-Suk, AU - Lee,Tae Yong, AU - Samet,Jonathan M, Y1 - 2005/10/12/ PY - 2005/10/14/pubmed PY - 2006/1/6/medline PY - 2005/10/14/entrez SP - 1062 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 11 N2 - The authors conducted a 10-year prospective cohort study of mortality in relation to white blood cell counts of 437,454 Koreans, aged 40-95 years, who received health insurance from the National Health Insurance Corporation and were medically evaluated in 1993 or 1995, with white blood cell measurement. The main outcome measures were mortality from all causes, all cancers, and all atherosclerotic cardiovascular diseases (ASCVD). Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models with adjustment for age and potential confounders. During follow-up, 48,757 deaths occurred, with 15,507 deaths from cancer and 11,676 from ASCVD. For men and women, white blood cell count was associated with all-cause mortality and ASCVD mortality but not with cancer mortality. In healthy nonsmokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was observed in men (highest vs. lowest quintile: hazard ratio = 2.10, 95% confidence interval: 1.50, 2.94) and in women (hazard ratio = 1.35, 95% confidence interval: 1.17, 1.56). In healthy smokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was also observed in men (highest vs. lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16221804/White_blood_cell_count_and_risk_for_all_cause_cardiovascular_and_cancer_mortality_in_a_cohort_of_Koreans_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi326 DB - PRIME DP - Unbound Medicine ER -