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Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998-2000.
Am J Epidemiol. 2005 Nov 15; 162(10):953-64.AJ

Abstract

The role of dietary one-carbon determinants remains largely unexplored for non-Hodgkin's lymphoma (NHL). In a population-based case-control study of non-African-American adult (aged 20-74 years) women and men from four US Surveillance, Epidemiology, and End Results study centers (Detroit, Michigan; Iowa; Los Angeles, California; and Seattle, Washington; 1998-2000), the authors examined folate; vitamins B2, B6, and B12; methionine; and a one-carbon antagonist, alcohol, in 425 incident NHL cases and 359 controls who completed a detailed food frequency questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated by using unconditional logistic regression. Higher intake of one-carbon determinants from food was associated with a lower risk of NHL, but that for only vitamin B6 (highest vs. lowest quartile: odds ratio = 0.57, 95% confidence interval: 0.34, 0.95; p trend = 0.01) and methionine (odds ratio = 0.49, 95% confidence interval: 0.31, 0.76; p trend = 0.002) reached statistical significance. Folate from food was inversely associated with diffuse subtype (odds ratio = 0.47, 95% confidence interval: 0.23, 0.94; p trend = 0.03). The authors found no association between total (food plus supplement) vitamins and NHL. Nonusers of alcohol had an elevated NHL risk compared with users, and alcohol did not modify other nutrient-NHL associations. Findings suggest that one-carbon nutrients, particularly vitamin B6 and methionine, may be protective against NHL.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

16221809

Citation

Lim, U, et al. "Dietary Determinants of One-carbon Metabolism and the Risk of non-Hodgkin's Lymphoma: NCI-SEER Case-control Study, 1998-2000." American Journal of Epidemiology, vol. 162, no. 10, 2005, pp. 953-64.
Lim U, Schenk M, Kelemen LE, et al. Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998-2000. Am J Epidemiol. 2005;162(10):953-64.
Lim, U., Schenk, M., Kelemen, L. E., Davis, S., Cozen, W., Hartge, P., Ward, M. H., & Stolzenberg-Solomon, R. (2005). Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998-2000. American Journal of Epidemiology, 162(10), 953-64.
Lim U, et al. Dietary Determinants of One-carbon Metabolism and the Risk of non-Hodgkin's Lymphoma: NCI-SEER Case-control Study, 1998-2000. Am J Epidemiol. 2005 Nov 15;162(10):953-64. PubMed PMID: 16221809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998-2000. AU - Lim,U, AU - Schenk,M, AU - Kelemen,L E, AU - Davis,S, AU - Cozen,W, AU - Hartge,P, AU - Ward,M H, AU - Stolzenberg-Solomon,R, Y1 - 2005/10/12/ PY - 2005/10/14/pubmed PY - 2006/1/20/medline PY - 2005/10/14/entrez SP - 953 EP - 64 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 10 N2 - The role of dietary one-carbon determinants remains largely unexplored for non-Hodgkin's lymphoma (NHL). In a population-based case-control study of non-African-American adult (aged 20-74 years) women and men from four US Surveillance, Epidemiology, and End Results study centers (Detroit, Michigan; Iowa; Los Angeles, California; and Seattle, Washington; 1998-2000), the authors examined folate; vitamins B2, B6, and B12; methionine; and a one-carbon antagonist, alcohol, in 425 incident NHL cases and 359 controls who completed a detailed food frequency questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated by using unconditional logistic regression. Higher intake of one-carbon determinants from food was associated with a lower risk of NHL, but that for only vitamin B6 (highest vs. lowest quartile: odds ratio = 0.57, 95% confidence interval: 0.34, 0.95; p trend = 0.01) and methionine (odds ratio = 0.49, 95% confidence interval: 0.31, 0.76; p trend = 0.002) reached statistical significance. Folate from food was inversely associated with diffuse subtype (odds ratio = 0.47, 95% confidence interval: 0.23, 0.94; p trend = 0.03). The authors found no association between total (food plus supplement) vitamins and NHL. Nonusers of alcohol had an elevated NHL risk compared with users, and alcohol did not modify other nutrient-NHL associations. Findings suggest that one-carbon nutrients, particularly vitamin B6 and methionine, may be protective against NHL. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16221809/Dietary_determinants_of_one_carbon_metabolism_and_the_risk_of_non_Hodgkin's_lymphoma:_NCI_SEER_case_control_study_1998_2000_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi310 DB - PRIME DP - Unbound Medicine ER -