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The role and significance of sputum cultures in the diagnosis of melioidosis.
Am J Trop Med Hyg. 2005 Oct; 73(4):657-61.AJ

Abstract

Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis.

Authors+Show Affiliations

Huis in 't Veld D
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Wuthiekanun V
No affiliation info available
Cheng AC
No affiliation info available
Chierakul W
No affiliation info available
Chaowagul W
No affiliation info available
Brouwer AE
No affiliation info available
White NJ
No affiliation info available
Day NP
No affiliation info available
Peacock SJ
No affiliation info available

MeSH

AdultBurkholderia pseudomalleiCulture MediaFemaleHumansMaleMelioidosisMiddle AgedPneumonia, BacterialPrognosisSputum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16222004

Citation

Huis in 't Veld, Diana, et al. "The Role and Significance of Sputum Cultures in the Diagnosis of Melioidosis." The American Journal of Tropical Medicine and Hygiene, vol. 73, no. 4, 2005, pp. 657-61.
Huis in 't Veld D, Wuthiekanun V, Cheng AC, et al. The role and significance of sputum cultures in the diagnosis of melioidosis. Am J Trop Med Hyg. 2005;73(4):657-61.
Huis in 't Veld, D., Wuthiekanun, V., Cheng, A. C., Chierakul, W., Chaowagul, W., Brouwer, A. E., White, N. J., Day, N. P., & Peacock, S. J. (2005). The role and significance of sputum cultures in the diagnosis of melioidosis. The American Journal of Tropical Medicine and Hygiene, 73(4), 657-61.
Huis in 't Veld D, et al. The Role and Significance of Sputum Cultures in the Diagnosis of Melioidosis. Am J Trop Med Hyg. 2005;73(4):657-61. PubMed PMID: 16222004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role and significance of sputum cultures in the diagnosis of melioidosis. AU - Huis in 't Veld,Diana, AU - Wuthiekanun,Vanaporn, AU - Cheng,Allen C, AU - Chierakul,Wirongrong, AU - Chaowagul,Wipada, AU - Brouwer,Annemarie E, AU - White,Nicholas J, AU - Day,Nicholas P J, AU - Peacock,Sharon J, PY - 2005/10/14/pubmed PY - 2006/1/6/medline PY - 2005/10/14/entrez SP - 657 EP - 61 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 73 IS - 4 N2 - Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/16222004/The_role_and_significance_of_sputum_cultures_in_the_diagnosis_of_melioidosis_ DB - PRIME DP - Unbound Medicine ER -