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Short report: Abnormal liver function in scrub typhus.
Am J Trop Med Hyg 2005; 73(4):667-8AJ

Abstract

Scrub typhus is one kind of rickettsial disease and may cause fever, cough, and skin rashes in infected humans. Regarding liver involvement, it was uncommon to be reported in previous medical literature from Western countries. This study observes the relationship between scrub typhus and liver function. From January 1998 to August 2003 in Kaohsiung Chang Gung Memorial Hospital in Taiwan, we observed 30 patients with scrub typhus, and 29 of them had liver function abnormality. In these patients, we found 89.3% with elevated aspartate aminotransferase (AST) levels, 91.7% with elevated alanine aminotransferase (ALT) levels, 84.2% with elevated alkaline phosphatase (ALP) levels, and 38.5% with elevated total bilirubin levels. In our study, there is a close relationship between scrub typhus and impaired liver function tests. Therefore, if patients are found with fever of unknown origin and abnormal liver function, we should take scrub typhus into consideration.

Authors+Show Affiliations

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16222006

Citation

Hu, Ming-Luen, et al. "Short Report: Abnormal Liver Function in Scrub Typhus." The American Journal of Tropical Medicine and Hygiene, vol. 73, no. 4, 2005, pp. 667-8.
Hu ML, Liu JW, Wu KL, et al. Short report: Abnormal liver function in scrub typhus. Am J Trop Med Hyg. 2005;73(4):667-8.
Hu, M. L., Liu, J. W., Wu, K. L., Lu, S. N., Chiou, S. S., Kuo, C. H., ... Changchien, C. S. (2005). Short report: Abnormal liver function in scrub typhus. The American Journal of Tropical Medicine and Hygiene, 73(4), pp. 667-8.
Hu ML, et al. Short Report: Abnormal Liver Function in Scrub Typhus. Am J Trop Med Hyg. 2005;73(4):667-8. PubMed PMID: 16222006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short report: Abnormal liver function in scrub typhus. AU - Hu,Ming-Luen, AU - Liu,Jien-Wei, AU - Wu,Keng-Liang, AU - Lu,Sheng-Nan, AU - Chiou,Shue-Shian, AU - Kuo,Chung-Huang, AU - Chuah,Seng-Kee, AU - Wang,Jing-Houng, AU - Hu,Tsung-Hui, AU - Chiu,King-Wah, AU - Lee,Chuan-Mo, AU - Changchien,Chi-Sin, PY - 2005/10/14/pubmed PY - 2006/1/6/medline PY - 2005/10/14/entrez SP - 667 EP - 8 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 73 IS - 4 N2 - Scrub typhus is one kind of rickettsial disease and may cause fever, cough, and skin rashes in infected humans. Regarding liver involvement, it was uncommon to be reported in previous medical literature from Western countries. This study observes the relationship between scrub typhus and liver function. From January 1998 to August 2003 in Kaohsiung Chang Gung Memorial Hospital in Taiwan, we observed 30 patients with scrub typhus, and 29 of them had liver function abnormality. In these patients, we found 89.3% with elevated aspartate aminotransferase (AST) levels, 91.7% with elevated alanine aminotransferase (ALT) levels, 84.2% with elevated alkaline phosphatase (ALP) levels, and 38.5% with elevated total bilirubin levels. In our study, there is a close relationship between scrub typhus and impaired liver function tests. Therefore, if patients are found with fever of unknown origin and abnormal liver function, we should take scrub typhus into consideration. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/16222006/Short_report:_Abnormal_liver_function_in_scrub_typhus_ L2 - http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=16222006 DB - PRIME DP - Unbound Medicine ER -