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Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake.
J Nutr Health Aging. 2005 Sep-Oct; 9(5):347-51.JN

Abstract

The influence of calcitropic hormones on functional mobility has been studied in vitamin D (calcidiol) deficient elderly or elderly with a history of falls, however, data in community-dwelling independent vitamin D replete elderly are missing. We therefore assessed in an observational survey the association of calcidiol (25(OH)D3) and calcitriol (D-hormone / 1,25(OH)2D3) status as well as of daily calcium intake on functional mobility in older subjects We evaluated 192 women and 188 men, aged superior 70 years and living independently. Average Timed-up and go test (TUG-test) in seconds was taken as measure of functional mobility. Calcidiol and D-hormone serum concentrations and daily calcium intake were studied in multivariate controlled linear regression models with TUG-test performance as the dependent variable and/or as dichotomous variables (deficient vs. non-deficient, above vs. below the median, respectively). Subjects with low D-hormone serum concentrations took significantly more time to perform the TUG-test (low = 7.70s +/- 2.52 SD ; high = 6.70s +/- 1.29 SD; p = 0.004). In the linear multivariate controlled regression model increased D-hormone serum concentrations predicted better TUG-test performance (estimate -0.0007, p = 0.044). Participants with a calcium intake of > or =512 mg/day were significantly faster to perform the TUG-test than participants with a daily calcium intake of <512 mg/day (estimate:-0.43, p = 0.007). Other significant predictors of better TUG-test performance in both models were: male gender, less comorbid conditions, younger age, lower BMI, iPTH serum levels and creatinine clearance. Calcidiol serum levels were not associated with TUG-test performance. Higher D-hormone status and a calcium intake of > or =512 mg/day in community-dwelling independent older persons are significant determinants of better functional mobility. Therefore, to ensure optimal functional mobility, the care of older persons should address correction of D-hormone deficiency and increasing daily calcium intake.

Authors+Show Affiliations

Ambulatorium Wiesendamm, Wiesendamm 22, 4057 Basel, Switzerland. l.d@gmx.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16222401

Citation

Dukas, L, et al. "Better Functional Mobility in Community-dwelling Elderly Is Related to D-hormone Serum Levels and to Daily Calcium Intake." The Journal of Nutrition, Health & Aging, vol. 9, no. 5, 2005, pp. 347-51.
Dukas L, Staehelin HB, Schacht E, et al. Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake. J Nutr Health Aging. 2005;9(5):347-51.
Dukas, L., Staehelin, H. B., Schacht, E., & Bischoff, H. A. (2005). Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake. The Journal of Nutrition, Health & Aging, 9(5), 347-51.
Dukas L, et al. Better Functional Mobility in Community-dwelling Elderly Is Related to D-hormone Serum Levels and to Daily Calcium Intake. J Nutr Health Aging. 2005 Sep-Oct;9(5):347-51. PubMed PMID: 16222401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake. AU - Dukas,L, AU - Staehelin,H B, AU - Schacht,E, AU - Bischoff,H A, PY - 2005/10/14/pubmed PY - 2006/1/13/medline PY - 2005/10/14/entrez SP - 347 EP - 51 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 9 IS - 5 N2 - The influence of calcitropic hormones on functional mobility has been studied in vitamin D (calcidiol) deficient elderly or elderly with a history of falls, however, data in community-dwelling independent vitamin D replete elderly are missing. We therefore assessed in an observational survey the association of calcidiol (25(OH)D3) and calcitriol (D-hormone / 1,25(OH)2D3) status as well as of daily calcium intake on functional mobility in older subjects We evaluated 192 women and 188 men, aged superior 70 years and living independently. Average Timed-up and go test (TUG-test) in seconds was taken as measure of functional mobility. Calcidiol and D-hormone serum concentrations and daily calcium intake were studied in multivariate controlled linear regression models with TUG-test performance as the dependent variable and/or as dichotomous variables (deficient vs. non-deficient, above vs. below the median, respectively). Subjects with low D-hormone serum concentrations took significantly more time to perform the TUG-test (low = 7.70s +/- 2.52 SD ; high = 6.70s +/- 1.29 SD; p = 0.004). In the linear multivariate controlled regression model increased D-hormone serum concentrations predicted better TUG-test performance (estimate -0.0007, p = 0.044). Participants with a calcium intake of > or =512 mg/day were significantly faster to perform the TUG-test than participants with a daily calcium intake of <512 mg/day (estimate:-0.43, p = 0.007). Other significant predictors of better TUG-test performance in both models were: male gender, less comorbid conditions, younger age, lower BMI, iPTH serum levels and creatinine clearance. Calcidiol serum levels were not associated with TUG-test performance. Higher D-hormone status and a calcium intake of > or =512 mg/day in community-dwelling independent older persons are significant determinants of better functional mobility. Therefore, to ensure optimal functional mobility, the care of older persons should address correction of D-hormone deficiency and increasing daily calcium intake. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/16222401/Better_functional_mobility_in_community_dwelling_elderly_is_related_to_D_hormone_serum_levels_and_to_daily_calcium_intake_ L2 - https://medlineplus.gov/calcium.html DB - PRIME DP - Unbound Medicine ER -