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Mechanisms of vascular disease in hypertension with special reference to diabetes.

Abstract

In this article, it is proposed that the epidemiological observations regarding the measures of blood pressure and cardiovascular risk suggest that the vascular damage of hypertension is powerfully related to vessel stiffness. Several phenotypes within the hypertensive population, including salt sensitivity, central obesity, insulin resistance, and nonmodulating hypertension, cluster with vascular risk, and the features of the high-risk phenotype suggest a common antecedent characterizing the patient with the elevated cardiovascular risk associated with high blood pressure. The article also explores the relationship between blood pressure lowering and outcome, concluding that it is not yet fully understood how elevation of blood pressure increases risk or how reducing it produces benefit.

Authors+Show Affiliations

Diabetes and Cardiovascular Disease Academic Unit, Royal Free and University College Medical School, London, England. rmhajsy@ucl.ac.uk

Source

Seminars in vascular medicine 2:2 2002 May pg 139-48

MeSH

Antihypertensive Agents
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Glucose Intolerance
Humans
Hypertension
Insulin Resistance
Kidney Diseases
Obesity
Treatment Outcome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16222605

Citation

Yudkin, John S.. "Mechanisms of Vascular Disease in Hypertension With Special Reference to Diabetes." Seminars in Vascular Medicine, vol. 2, no. 2, 2002, pp. 139-48.
Yudkin JS. Mechanisms of vascular disease in hypertension with special reference to diabetes. Semin Vasc Med. 2002;2(2):139-48.
Yudkin, J. S. (2002). Mechanisms of vascular disease in hypertension with special reference to diabetes. Seminars in Vascular Medicine, 2(2), pp. 139-48.
Yudkin JS. Mechanisms of Vascular Disease in Hypertension With Special Reference to Diabetes. Semin Vasc Med. 2002;2(2):139-48. PubMed PMID: 16222605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of vascular disease in hypertension with special reference to diabetes. A1 - Yudkin,John S, PY - 2005/10/14/pubmed PY - 2005/11/9/medline PY - 2005/10/14/entrez SP - 139 EP - 48 JF - Seminars in vascular medicine JO - Semin Vasc Med VL - 2 IS - 2 N2 - In this article, it is proposed that the epidemiological observations regarding the measures of blood pressure and cardiovascular risk suggest that the vascular damage of hypertension is powerfully related to vessel stiffness. Several phenotypes within the hypertensive population, including salt sensitivity, central obesity, insulin resistance, and nonmodulating hypertension, cluster with vascular risk, and the features of the high-risk phenotype suggest a common antecedent characterizing the patient with the elevated cardiovascular risk associated with high blood pressure. The article also explores the relationship between blood pressure lowering and outcome, concluding that it is not yet fully understood how elevation of blood pressure increases risk or how reducing it produces benefit. SN - 1528-9648 UR - https://www.unboundmedicine.com/medline/citation/16222605/Mechanisms_of_vascular_disease_in_hypertension_with_special_reference_to_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -