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A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia-spectrum disorders in adulthood.
Acta Psychiatr Scand. 2005 Nov; 112(5):385-93.AP

Abstract

OBJECTIVE

Children with visual dysfunction have perinatal, neurological, visual-perceptual and cognitive abnormalities, similar to schizophrenia patients. We prospectively investigated whether visual dysfunction in childhood selectively predicts adult schizophrenia-spectrum disorders, and is related to childhood neurological abnormality.

METHOD

Offspring of mothers with and without a history of psychosis were prospectively assessed with vision tests at 4 years, neurological examinations at 6 years, and interviews for psychiatric disorders at follow-up (93% effective, n=166) at 22 years.

RESULTS

In the total sample and high-risk (HR) offspring, visual dysfunction at 4 years, and its severity, were associated only with schizophrenia-spectrum disorders in adulthood, and with neurological abnormality at 6 years.

CONCLUSION

Visual dysfunction at 4 years of age selectively predicts schizophrenia-spectrum disorders in adulthood among HR offspring, this likely reflecting disturbed neurological development.

Authors+Show Affiliations

Unit of Psychiatric Epidemiology, University Hospital, Lund University, Lund, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16223427

Citation

Schubert, E W., et al. "A Prospective Study of Offspring of Women With Psychosis: Visual Dysfunction in Early Childhood Predicts Schizophrenia-spectrum Disorders in Adulthood." Acta Psychiatrica Scandinavica, vol. 112, no. 5, 2005, pp. 385-93.
Schubert EW, Henriksson KM, McNeil TF. A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia-spectrum disorders in adulthood. Acta Psychiatr Scand. 2005;112(5):385-93.
Schubert, E. W., Henriksson, K. M., & McNeil, T. F. (2005). A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia-spectrum disorders in adulthood. Acta Psychiatrica Scandinavica, 112(5), 385-93.
Schubert EW, Henriksson KM, McNeil TF. A Prospective Study of Offspring of Women With Psychosis: Visual Dysfunction in Early Childhood Predicts Schizophrenia-spectrum Disorders in Adulthood. Acta Psychiatr Scand. 2005;112(5):385-93. PubMed PMID: 16223427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia-spectrum disorders in adulthood. AU - Schubert,E W, AU - Henriksson,K M, AU - McNeil,T F, PY - 2005/10/15/pubmed PY - 2006/1/13/medline PY - 2005/10/15/entrez SP - 385 EP - 93 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 112 IS - 5 N2 - OBJECTIVE: Children with visual dysfunction have perinatal, neurological, visual-perceptual and cognitive abnormalities, similar to schizophrenia patients. We prospectively investigated whether visual dysfunction in childhood selectively predicts adult schizophrenia-spectrum disorders, and is related to childhood neurological abnormality. METHOD: Offspring of mothers with and without a history of psychosis were prospectively assessed with vision tests at 4 years, neurological examinations at 6 years, and interviews for psychiatric disorders at follow-up (93% effective, n=166) at 22 years. RESULTS: In the total sample and high-risk (HR) offspring, visual dysfunction at 4 years, and its severity, were associated only with schizophrenia-spectrum disorders in adulthood, and with neurological abnormality at 6 years. CONCLUSION: Visual dysfunction at 4 years of age selectively predicts schizophrenia-spectrum disorders in adulthood among HR offspring, this likely reflecting disturbed neurological development. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16223427/A_prospective_study_of_offspring_of_women_with_psychosis:_visual_dysfunction_in_early_childhood_predicts_schizophrenia_spectrum_disorders_in_adulthood_ L2 - https://doi.org/10.1111/j.1600-0447.2005.00584.x DB - PRIME DP - Unbound Medicine ER -